Investigation for renewal treatment strategy for small cell lung cancer: Imaging biomarker of neutropenia in amrubicin treatment

• Project/Area Number: 25870610
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy; Tumor therapeutics
• Research Institution: Nagoya City University
• Principal Investigator: Takakuwa Osamu 名古屋市立大学, 医学(系)研究科(研究院), 助教 (10647332)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 小細胞肺癌 / 抗癌剤治療 / 一塩基多型 / アムルビシン / SNP / 肺癌 / バイオマーカー / 一遺伝子多型

Outline of Final Research Achievements

Aim of this study is to find a clinical biomarker for amrubicin treatment and its mechanism. We found that polymorphisms of ABCB1 have relationship with amrubicin-induced neutropenia. Also, we had a result that area under the plasma concentration versus time curve (AUC) values of amrubicinol have a significant relation with grade of neutropenia during amrubicin treatment. However, we could not reach to identify the factor which regulates AUC value of amrubicinol. We now focus on organic cation transporter (OCT) and have continued to investigate factors which regulate pharmacological function of amrubicin.

Research Products

• [Journal Article] ABCB1 polymorphism as a predictive biomarker for amrubicin-induced neutropenia (2014)
  • Author(s): Takakuwa O, Oguri T, Uemura T, Kunii E, Nakao M, Hijikata H, Kawaguchi Y, Ohkubo H, Takemura M, Maeno K, Niimi A.
  • Journal Title: Ａｎｔｉｃａｎｃｅｒ Ｒｅｓ Volume: 34 Pages: 3517-3522
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] アムルビシン治療におけるアムルビシノール血中濃度と好中球減少症の関連の検討 (2014)
  • Author(s): 高桑 修、小栗鉄也、上村剛大、國井英治、福光研介、武田典久、川口裕子、大久保仁嗣、竹村昌也、前野 健、新実彰男
  • Organizer: 肺癌学会総会
  • Place of Presentation: 国立京都国際会館（京都府・京都市）
  • Year and Date: 2014-11-14 – 2014-11-16
• [Presentation] ABCB1 polymorphisms as a predictive biomarker of neutropenia induced by amrubicin (2013)
  • Author(s): Osamu Takakuwa, Tetsuya Oguri, Takehiro Uemura, Eiji Kunii, Hisatoshi Hijikata, Midori Yokoyama, Hirotsugu Ohkubo, Masaya Takemura, Ken Maeno, Akio Niimi
  • Organizer: European Cancer Congress 2013
  • Place of Presentation: ライ･アムステルダム国際展示会場（Amsterdam, オランダ）
• [Presentation] アムルビシンによる好中球減少におけるABCB1遺伝子多型の関与 (2013)
  • Author(s): 高桑 修，小栗鉄也，國井英治，上村剛大，浅野貴光、市川博也、竹村昌也，前野 健，新実彰男
  • Organizer: 肺癌学会総会
  • Place of Presentation: ホテルニューオータニ（東京）