| Project/Area Number |
25870634
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Nara Medical University |
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Principal Investigator |
HORII Noriko 奈良県立医科大学, 医学部, 助教 (80433332)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 視床下部 / ペリニューロナルネット / ストレス / エンケファリン / 外側中隔 / 不安 / 大脳辺縁系 / 脳弓周囲核 / カルレチニン / コンドロイチン硫酸プロテオグリカン |
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| Outline of Final Research Achievements |
The hypothalamus of the brain is phylogenically old and plays important roles in the maintenance of life by regulating autonomic nervous system and behaviors related with feeding, drinking the water, sleep and reproduction etc.. Now, the hypothalamus is divided into more than 10 compartments based on histological characteristics and physiological functions. In the present study, we found and characterized a new hypothalamic region in the mouse brain. Our data demonstrate that this new region is composed of enkephalin-producing neurons and possesses bidirectional neural connections with the lateral septum. Furthermore, these neurons respond to psychological stressors and are suggested to control anxiety level. This study provides basic information in hypothalamic neuroanatomy and is important for understanding the roles of the neural connections between the hypothalamus and the limbic system.
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