New concept of pathogenesis of glaucomatous optic neuropathy using novel optical coherence tomography with white laser lightsource

• Project/Area Number: 25870678
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology; Medical systems
• Research Institution: Saitama Medical University
• Principal Investigator: SHOJI TAKUHEI 埼玉医科大学, 医学部, 講師 (70637058)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 光干渉断層計 / 緑内障 / 篩状板 / 視神経乳頭篩状板

Outline of Final Research Achievements

We generated novel Optocal Coherent Tomography (OCT) devise using mode-locked Ti: sapphire laser as lightsource. The depth resolution was measured to be less than 2.0 μm into the tissue. A raster scanning protocol with 300 B-scans covering a 3.0 × 3.0 mm square region centered at the optiv nerve head was used for volumetric scans.

Research Products

• [Journal Article] Three-dimensional optic nerve head images using optical coherence tomography with a broad bandwidth, femtosecond, and mode-locked laser. (2015)
  • Author(s): Shoji T, Kuroda H, Suzuki M, Baba M, Araie M, Yoneya S.
  • Journal Title: Graefe's archive for clinical and experimental ophthalmology Volume: 253 Issue: 2 Pages: 313-321
  • DOI: 10.1007/s00417-014-2870-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Correlation between Lamina Cribrosa Tilt Angles, Myopia and Glaucoma Using OCT with a Wide Bandwidth Femtosecond Mode-Locked Laser. (2014)
  • Author(s): Shoji T, Kuroda H, Suzuki M, Baba M, Hangai M, Araie M, Yoneya S.
  • Journal Title: PLoS One. Volume: 9 Issue: 12 Pages: e116305-e116305
  • DOI: 10.1371/journal.pone.0116305
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Vertical asymmetry of lamina criborosa tilt angles from Bruch’s membrane opening plane (2015)
  • Author(s): Takuhei Shoji, Hiroto Kuroda, Masayuki Suzuki, Makoto Araie, Masanori Hangai, Shin Yoneya
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2015 Annual Meeting
  • Place of Presentation: Denver
  • Year and Date: 2015-05-03 – 2015-05-07
• [Presentation] Preperimetric glaucoma、篩状板の構造変化 (2015)
  • Author(s): 庄司拓平
  • Organizer: 第119回日本眼科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2015-04-16 – 2015-04-19
  • Invited
• [Presentation] 高解像度OCTによる篩状板構造 (2014)
  • Author(s): 庄司拓平
  • Organizer: 第25回日本緑内障学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-09-20
  • Invited
• [Presentation] Correlation between Myopia, Glaucoma and Lamina Cribrosa Tilt Angle Using Broad Wavelength Laser Optical Coherence Tomography (2014)
  • Author(s): Takuhei Shoji, Hiroto Kuroda, Masayuki Suzuki, Motoyoshi Baba, Masanori Hangai, Makoto Araie, Shin Yoneya
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2014 Annual Meeting
  • Place of Presentation: Orland
  • Year and Date: 2014-05-04 – 2014-05-08
• [Presentation] 篩状板のブルッフ膜面に対する傾斜角度と緑内障および近視との関連 (2014)
  • Author(s): 庄司 拓平, 黒田 寛人, 鈴木 将之, 伊吹 寿士, 馬場 基芳, 板谷 正紀, 新家 眞, 米谷 新
  • Organizer: 第118回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-02 – 2014-04-06
• [Presentation] 広帯域レーザー光干渉断層計による視神経乳頭における動脈拍動計測 (2014)
  • Author(s): 鈴木 将之, 黒田 寛人, 庄司 拓平, 馬場 基芳, 板谷 正紀, 米谷 新
  • Organizer: 第118回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-02 – 2014-04-06
• [Presentation] Observation of human lamina cribrosa in vivo using a novel high sensitive, high resolution optical coherence tomography (2013)
  • Author(s): Takuhei Shoji
  • Organizer: ARVO 2013 Annual Meeting
  • Place of Presentation: Seattle, USA
• [Presentation] In Vivo Imaging of Lamina Cribrosa Sheet by Novel High-resolution, Broad-wavelength Laser OCT (2013)
  • Author(s): Takuhei Shoji
  • Organizer: American Academy of Ophthalmology, Annual Meeting
  • Place of Presentation: New Orleans , USA
• [Book] あたらしい眼科 (2014)
  • Author(s): 庄司拓平
  • Publisher: メディカル葵出版
• [Book] Retina Medicine (2014)
  • Author(s): 庄司拓平，板谷正紀
  • Publisher: 先端医学社
• [Book] 週刊医事新報 (2014)
  • Author(s): 庄司拓平，板谷正紀
  • Publisher: 週刊医事新報社
• [Book] 脳21 (2014)
  • Author(s): 庄司拓平，板谷正紀
  • Publisher: 金芳堂