| Project/Area Number |
25870729
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
Pain science
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| Research Institution | Tokai University |
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Principal Investigator |
KAMO Atsuko 東海大学, 健康科学部, 講師 (50614088)
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| Research Collaborator |
TAKAMORI Kenji
TOMINAGA Mitsutoshi
KAMATA Yayoi
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 難治性痒み / 表皮内神経線維 / エキシマランプ / アトピー性皮膚炎 / ドライスキン / ドライスキンモデルマウス / 光産物 |
|---|
| Outline of Final Research Achievements |
In this study, we aimed to investigate the effects of excimer lamp on intraepidermal nerve fibers directly and on pruritus of atopic dermatitis (AD) model mice. Irradiation to nerve fibers in cultured dorsal root ganglion neurons increased bleb formation and decreased nerve fiber expression of nicotinamide mononucleotide adenylyl transferase 2, suggesting degenerative changes in these fibers. A single irradiation to AD model mice significantly inhibited itch-related behavior one day later, following improvement in the dermatitis score. These results suggested that excimer lamp is one of effective therapies against intractable pruritus involving intraepidermal nerve fibers.
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