| Project/Area Number |
25870836
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
Chemical biology
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| Research Institution | Komazawa University |
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Principal Investigator |
Okada Tomoko 駒澤大学, 医療健康科学部, 講師 (60409795)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Ikuro 東北工業大学, 工学部, 講師 (90516311)
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| Research Collaborator |
HONDA Masayuki
ODAWARA Aoi
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | コラーゲンペプチド / 近赤外 / 集積 / 光熱治療 / がん細胞 / 近赤外光 / がん / 糖鎖 / 造影剤 |
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| Outline of Final Research Achievements |
This study aimed to develop a novel structural motif of imaging and therapeutic agent for cancer cells. A novel agent was designed and synthesized by conjugation of collagen peptide and a near-infrared (NIR) responsive dye. The collagen peptide was incorporated for targeting collagen fibrils around cancer cells and the NIR dye was for triggering cytotoxicity in human glioma cells. The effective cytotoxicity was achieved by association of the collagen peptide with the collagen surrounding the cells. The results obtained in this study suggest a novel approach for delivering therapeutic imaging agent to targeting cells.
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