| Project/Area Number |
25870846
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
Gastroenterology
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| Research Institution | Juntendo University (2016)
Tokyo Health Care University (2013-2015) |
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Principal Investigator |
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| Research Collaborator |
NAKAJIMA Atsushi 横浜市立大学, 医学部, 教授
PURI Raj, K US Food and Drug Administration, Center for Biologics Evluation and Research Organization, Department director
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | IL-13Ralpha2 / 膵臓癌 / 浸潤 / 転移 / 生命予後 / ポリフェノール / 神経浸潤 / HAT阻害薬 / Epigallocatechin gallate / IL-13Rα2 / HAT inhibitor / 膵臓癌マウスモデル / 予後規定因子 / IL13Ralpha2 / 国際情報交換(アメリカ) / エピジェネティクス / 転移抑制 / 国際情報交換 |
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| Outline of Final Research Achievements |
We examined the relationship between the expression of IL-13Ralpha2 and survival time using the surgically resected samples of pancreatic cancer. Totally, 236 samples were examined, and they indicated that IL-13Ralpha2-high expresser showed significantly short survival time. Furthermore, IL-13Ralpha2 could enhance invasion to the nerve, because the expression of IL-13Ralpha2 showed strong correlation with the perineural invasion.
Then, we examined the cancer therapy targeting IL-13Ralpha2. Epigallocatechin gallate (EGCG) included in the green tea suppressed the expression of IL-13Ralpha2 in the pancreatic cancer cells. Orally administered ECGC extended the survival time of the host in the model mouse of pancreatic cancer.
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