| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Recently, involvement of the sympathetic nervous system on bone metabolism has attracted attention. Osteoblastic and osteoclastic cells are presented β2-adrenergic receptor (β2-AR). In this study, the effects of butoxamine (BUT), a specific β2-AR antagonist on tooth movement were examined in spontaneously hypertensive rats (SHR) showing osteoporosis with hyperactivity of the sympathetic nervous system. The distance in the SHR control was longer than that in the Wistar-Kyoto rats (WKY) group, and no significant difference was found in the SHR treated with BUT compared with the WKY control. And BUT treatment resulted in a recovery of alveolar bone loss. These results suggest that the sympathetic nervous system is involved in tooth movement, and that BUT prevents alveolar bone loss by orthodontic tooth movement.
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