Leishmanicidal constituents from tropical plants and biochemical mechanism of the activity
Project/Area Number |
25870985
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Natural medicines
Chemical pharmacy
|
Research Institution | Tokushima Bunri University |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | リーシュマニア症 / 熱帯植物 / ミャンマー / 構造決定 / 抗リーシュマニア活性 / ペルー / 天然物化学 |
Outline of Final Research Achievements |
We investigated the leishmanicidal constituents from tropical plants and attempted to build a new screening system to elucidate the biochemical mechanism of the leishmanicidal activity. Several extracts from the plants belonging to Caricaceae, Verbenaceae, and Zingiberaceae, were found to inhibit the activity in the first screening. Twenty-eight compounds were isolated, and their activity as well as cytotoxicity against RAW 264.7 was examined. Additionally, the active compounds were subjected to an ATP-bioluminescence assay for measuring intracellular ATP level of promastigotes.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Biogenic Polyamines Capture CO2 and Accelerate Extracellular Bacterial CaCO3 Formation2014
Author(s)
Ko Yasumoto, Mina Yasumoto-Hirose, Jun Yasumoto, Ryo Murata, Shun-ichi Sato, Megumi Baba, Kanami Mori-Yasumoto, Mitsuru Jimbo, Yasukatsu Oshima, Takenori Kusumi, Shugo Watabe
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Journal Title
Marine Biotechnology
Volume: 印刷中
Issue: 4
Pages: 465-474
DOI
Related Report
Peer Reviewed
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[Journal Article] N’-[2-(7,8-Dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H) -yl)ethylidene]-4-nitrobenzohydrazide.2014
Author(s)
Morikawa M., Kino K., Asada E., Katagiri K., Mori-Yasumoto K., Suzuki M., Kobayashi T., Miyazawa H.
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Journal Title
Molbank
Volume: 2014
Issue: 4
Pages: M836-M836
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] New leishmanicidal stilbenes from a Peruvian folk medicine, Lonchocarpus2013
Author(s)
Hiroyuki Fuchino, Fumiyuki Kiuchi, Azusa Yamanaka, Akihiro Obu, Hiroshi Wada, Kanami Mori-Yasumoto, Nobuo Kawahara, Diana Flores, Olga Palacios, Setsuko Sekita, Motoyoshi Satake
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Journal Title
Chemical and Pharmaceutical Bulletin
Volume: 61(9)
Pages: 979-982
Related Report
Peer Reviewed
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[Journal Article] Involvement of brain oxidation in the cognitive impairment in a triple transgenic mouse model of Alzheimer's disease: Non-invasive measurement of the brain redox state by magnetic resonance imaging.2013
Author(s)
Ishihara Y, Itoh K, Mitsuda Y, Shimada T, Kubota T, Kato C, Song SY, Kobayashi Y, Mori-Yasumoto K, Sekita S, Kirino Y, Yamazaki T, Shimamoto N.
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Journal Title
Free Radic Res.
Volume: 47
Issue: 9
Pages: 731-739
DOI
Related Report
Peer Reviewed
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