| Project/Area Number |
25870985
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Natural medicines
Chemical pharmacy
|
|---|
| Research Institution | Tokushima Bunri University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | リーシュマニア症 / 熱帯植物 / ミャンマー / 構造決定 / 抗リーシュマニア活性 / ペルー / 天然物化学 |
|---|
| Outline of Final Research Achievements |
We investigated the leishmanicidal constituents from tropical plants and attempted to build a new screening system to elucidate the biochemical mechanism of the leishmanicidal activity. Several extracts from the plants belonging to Caricaceae, Verbenaceae, and Zingiberaceae, were found to inhibit the activity in the first screening. Twenty-eight compounds were isolated, and their activity as well as cytotoxicity against RAW 264.7 was examined. Additionally, the active compounds were subjected to an ATP-bioluminescence assay for measuring intracellular ATP level of promastigotes.
|
