| Project/Area Number |
25871135
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurophysiology / General neuroscience
Experimental psychology
|
|---|
| Research Institution | Institute of Physical and Chemical Research |
|---|
Principal Investigator |
Yoshida Takamasa 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (50525904)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | トップダウン型注意 / 視覚的注意 / 頭部固定型課題 / マウス視覚野 / 皮質ネットワーク / カルシウムイメージング / 全脳広域イメージング / 頭部固定型視覚的注意課題 / ネトリンG1 |
|---|
| Outline of Final Research Achievements |
Although it is thought that attentional top-down signal from higher-order cortices regulates neural activity in the visual cortex, there has been no direct evidence. In this study, I have planned, firstly, to develop a visual attention task system using head-restricted mice and, secondly, to capture top-down input signal as calcium signal at the axon terminals using two-photon microscopy. However, some studies that introduced the similar concept were published after starting this study. The latter part was changed into development of a wide-field calcium imaging system in order to improve the achievement level of the goal. As a result, the cortex-wide imaging suggested a mechanism of multisensory integration involving attention in the association cortices.
|
