Elucidation of a novel sleep-regulatory mechanism by the striatum

• Project/Area Number: 25890005
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: University of Tsukuba
• Principal Investigator: OISHI Yo 筑波大学, 国際統合睡眠医科学研究機構, 研究員 (70554004)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 睡眠

Outline of Final Research Achievements

We investigated the sleep-regulatory mechanism by the striatum. We divided the striatum to rostral, central, and caudal parts, activated each region, and measured sleep amount of each animal based on electroencephalogram/electromyogram recordings. Activation of the rostral striatum increased sleep. These results suggest that the rostral striatum may regulate sleep.