Identification and elucidation of functional relationship between neuronal exosomal ncRNA and Lewy body dementia

Research Project

Project/Area Number	25890012
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Neurophysiology / General neuroscience
Research Institution	Osaka University
Principal Investigator	KAWAHARA Hironori 大阪大学, 免疫学フロンティア研究センター, 特任研究員 (00424177)
Project Period (FY)	2013-08-30 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	exosome / α-synuclein / IP3 / ncRNA / 脳神経疾患
Outline of Final Research Achievements	Exosome is not only signal small vesicle which is utilized as cell-cell communication in various cells but also in neuronal cells. However, it remains unclear that the mechanisms by which neuronal exosomes are propagated within neuronal cells, particularly under IP3-stimulation. Novel lncRNAs (long non-coding RNAs) and proteins which were incorporated into IP3-stimulated exosomes were identified in mouse primary neurons. α-synuclein was efficiently incorporated into exosomes by Rpn1, and then efficiently transferred to glia cells via exosomes.

Report

(3 results)