| Project/Area Number |
25892027
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Animal production science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | L-アスパラギン酸 / 成長ホルモン / Umami受容体 / 反芻家畜 / アスパラギン酸 / ヒツジ / 味覚受容体 / 下垂体 / アミノ酸 |
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| Outline of Final Research Achievements |
In this study, we investigated whether L-Aspartic acid stimulates growth hormone (GH) via Umami receptor in the anterior pituitary of ruminants. This receptor was expressed in the anterior pituitary and the continuous intravenous infusion of L-Asp increased GH concentrations. However, L-Asp and L-Glutamic acid (L-Glu) did not stimulate GH secretion in the anterior pituitary that was sliced by Microslicer. Therefore, these results suggest that L-Asp does not directly act on the anterior pituitary to stimulate GH secretion and does not promote GH secretion via Umami receptor that is expressed in the anterior pituitary.
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