The role of polycomb complex on the clonal evolution in myelodysplastic syndrome
Project/Area Number |
25893049
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Hematology
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Research Institution | The University of Tokyo |
Principal Investigator |
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Project Period (FY) |
2013-08-30 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 骨髄異形成症候群 / ポリコーム |
Outline of Final Research Achievements |
Myelodysplastic syndrome (MDS) has a varied clinical course, with some patients remaining asymptomatic with mild cytopenia for a long time, while others show progressive leukemia a short time after the diagnosis. In the present study, we analyzed whether epigenetic alternation could contribute to the disease progression of MDS. It is suggested that alteration of oncogene expression is regulated by histone modification. This study suggested a new role of epigenetic alternation in the disease progression of MDS and possibilities of these processes as new targets of novel molecular therapy.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2.2015
Author(s)
Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K, Konuma T, Oda H, Wolff L, Honda ZI, Wu X, Helin K, Iwama A, Suda T, Inaba T, Honda H.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Granulocyte colony-stimulating factor combined regimen in cord blood transplantation for acute myeloid leukemia: a nationwide retrospective analysis in Japan.2014
Author(s)
1.Konuma T, Ooi J, Uchida N, Ogawa H, Ohashi K, Kanamori H, Aotsuka N, Onishi Y, Yamaguchi H, Kozai Y, Nagamura-Inoue T, Kato K, Suzuki R, Atsuta Y, Kato S, Asano S, Takahashi S.
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Journal Title
Haematologica
Volume: 99(12)
Issue: 12
Pages: e264-e268
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The TIF1β-HP1 System Maintains Transcriptional Integrity of Hematopoietic Stem Cells.2014
Author(s)
Miyagi S, Koide S, Saraya A, Wendt GR, Oshima M, Konuma T, Yamazaki S, Mochizuki-Kashio M, Nakajima-Takagi Y, Wang C, Chiba T, Kitabayashi I, Nakauchi H, Iwama A.
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Journal Title
Stem Cell Reports.
Volume: 2
Issue: 2
Pages: 145-52
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia.2014
Author(s)
Zimdahl B, Ito T, Blevins A, Bajaj J, Konuma T, Weeks J, Koechlein CS, Kwon HY, Arami O, Rizzieri D, Broome HE, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T.
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Journal Title
Nat Genet.
Volume: 46(3)
Issue: 3
Pages: 245-52
DOI
Related Report
Peer Reviewed
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