| Project/Area Number |
25893053
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Cardiovascular surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Research Collaborator |
MAKINO Yoshihisa 東京大学, 血管外科
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 抗炎症性脂質メディエーター / 内膜肥厚 / 動脈硬化 / 動脈瘤 |
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| Outline of Final Research Achievements |
To investigate the effect of anti-inflammatory lipid mediators on the intimal hyperplasia, we used a balloon injury model of the rat carotid artery. Resolvin D1 or protectin D was administered to the rat by iv-injection at two time points, just after injury and 2 days after injury, and normal saline (0.1% ethanol) was also injected as a control vehicle in the control group. We sacrificed the rat two weeks after injury and compared the intimal hyperplasia between the treated group and the control group. We used intima/media ratio (I/M ratio) to examine the intimal hyperplasia. The intimal hyperplasia was significantly attenuated in the treated vessels as compared to control vessels (control group (n=5), NI/M ratio=1.22±0.26 vs. Resolvin D1 group (n=6), NI/M ratio=0.85±0.14, p=0.031). We are repeating these experiments using the additional animal models and also statistically comparing the intimal hyperplasia between two groups.
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