Establishment of the mechanism analysis method of bioactive compounds based on the chemical genetics
| Project/Area Number |
25893142
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Natural medicines
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| Research Institution | Hiroshima University |
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Principal Investigator |
YAMANO YOSHI 広島大学, 医歯薬保健学研究院(薬), 助教 (70650597)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 線虫 / C. elegans / 抗寄生虫 / 生物活性物質 / 感染症 / 活性天然物 / Magnolol / Auraptenol |
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| Outline of Final Research Achievements |
we examined antiparasitic substance from plant extracts and tried to establish a new method for elucidating the action mechanism of active compounds. In this experiment, we used C. elegans as a model of parasite and isolated 14 compounds from 3 kinds of plants. Then the action mechanism of isolated compounds examined by using deletion mutant and drug-resistant mutant strain. The result showed that 4-hydroxyphenylpyruvate dioxygenase (HPD-1) is candidate of target molecule of proctorione C.
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Report
(3 results)
Research Products
(6 results)
