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Metabolome analysis of the molecular mechanism involved in the invasion and metastasis of lung cancer cells

Research Project

Project/Area Number 25893144
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Respiratory surgery
Research InstitutionNational Cancer Center Japan (2014)
Hiroshima University (2013)

Principal Investigator

SASADA SHINSUKE  独立行政法人国立がん研究センター, 中央病院, がん専門修練医 (30711329)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords腫瘍学 / 肺がん / 悪性度 / 肺癌 / 細胞遊走
Outline of Final Research Achievements

o analyze the molecular mechanism involved in the invasion and metastasis of lung cancer cells, lung cancer cell culture, assessment of migration ability and search for the patterns of low-molecular-weight cellular component were performed, and the analysis by vido-mass-scope was explored. In lung cancer cell lines with strong growth and migration ability, some amino acids, such as histidine, threonine and tyrosine, and carnitines were present specifically and the possibility that they were involved in proliferation and migration ability was suggested.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • Research Products

    (9 results)

All 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (4 results) (of which Invited: 1 results)

  • [Journal Article] Comparison of malignant grade between pure and partially invasive types of early lung adenocarcinoma2015

    • Author(s)
      Sasada S, Nakayama H, Miyata Y, Tsubokawa N, Mimae T, Yoshiya T, Murakami S, Ito H, Okada M
    • Journal Title

      Annals of Thoracic Surgery

      Volume: 99 Issue: 3 Pages: 956-960

    • DOI

      10.1016/j.athoracsur.2014.10.041

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of positron emission tomography/computed tomography findings for adjuvant chemotherapy indications in stage T1b-2aN0M0 lung adenocarcinoma2014

    • Author(s)
      Sasada S, Miyata Y, Tsubokawa N, Mimae T, Yoshiya T, Okada M
    • Journal Title

      Annals of Thoracic Surgery

      Volume: 98 Issue: 2 Pages: 417-422

    • DOI

      10.1016/j.athoracsur.2014.04.080

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肺がんに対する術後補助化学療法の進歩と展望2014

    • Author(s)
      笹田伸介、宮田義浩、岡田守人
    • Journal Title

      腫瘍内科

      Volume: 13 Pages: 73-78

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 化学療法中に血清G-CSF異常高値を伴う出血性小腸転移を来した原発性肺癌の1例2013

    • Author(s)
      笹田伸介、右近 圭、佐藤幸雄
    • Journal Title

      癌と化学療法

      Volume: 40 Pages: 777-780

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腸癌局所再発による排便時痛に対して人工肛門造設が著効し抗癌治療を継続した1例2013

    • Author(s)
      笹田伸介、右近 圭、佐藤幸雄
    • Journal Title

      癌と化学療法

      Volume: 40 Pages: 811-813

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Comparison of malignant grades between pure and partially invasive types of clinical stage IA lung adenocarcinoma2014

    • Author(s)
      Sasada S, Nakayama H, Miyata Y, Tsubokawa N, Mimae T, Yoshiya T, Murakami S, Ito H, Okada
    • Organizer
      ESMO 2014
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2014-09-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Analysis of incidental findings in FDG-PET/CT examination for cancer care2013

    • Author(s)
      笹田伸介
    • Organizer
      日本臨床腫瘍学会学術集会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] 埋め込み型中心静脈ポート感染における危険因子の検討2013

    • Author(s)
      笹田伸介
    • Organizer
      日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 悪性胸膜中皮腫における術前病理診断の意義とPET/CT検査を用いた組織型別治療戦略の検討2013

    • Author(s)
      笹田伸介
    • Organizer
      日本肺癌学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2013-09-12   Modified: 2019-07-29  

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