Expansion into the establishment of jaw cleft treatment with bone regeneration by use of mesenchymal stem cells with excellent ability to induce blood vessel
| Project/Area Number |
25893148
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
SUMI Keisuke 広島大学, 医歯薬保健学研究院(歯), 助教 (00707078)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 骨再生 / 未分化間葉系幹細胞 / 矯正歯科 / 矯正 / 再生医療 / 口唇裂口蓋裂 |
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| Outline of Final Research Achievements |
The aim of this study is bone regeneration of Jaw cleft of patients with cleft lip and palate (CLP) by use of mesenchymal stem cells (MSCs), so we examined the effects of MSCs on angiogenesis. From the results, it was suggested VEGF expression of MSCs was increased as compared with which of osteoblast differentiation, the angiogenesis of endothelial cells was promoted by coculture with MSCs. Additionally, vascularization of the transplanted area initial blood flow was increased and enhanced by transplantation of MSCs in vivo. So it was suggested that applications of this method may be available as a new therapeutic tool for CLP.
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Report
(3 results)
Research Products
(5 results)
