| Project/Area Number |
25893163
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMIZU Takahiko 千葉大学, 医学部, 准教授 (40301791)
KIRA Jun-ichi 九州大学, 医学部, 教授 (40183305)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | パーキンソン病 / 酸化ストレス / DJ-1 |
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| Outline of Final Research Achievements |
To investigate the role of mitochondrial dysfunction and oxidative stress in the dopaminergic neuronal death in PD(Parkinson's disease), we try to generate the dopaminergic neuron specific conditional knockout mice in which Superoxide dismutase-2(SOD2) is conditionally knocked out in dopaminergic neuron. We have established TH- CreER Tg mice and SOD2 (Superoxide dismutase-2) flox/flox mice colonies. To investigate the role of DJ-1, a responsible gene for PD,in the dopaminergic neuronal death, we will breed DJ-1 KO mice with dopaminergic neuron specific SOD2 conditional knockout mice and analyze.
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