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Mechanism analysis of lasting of AIDS virus control with SIV controllers.

Research Project

Project/Area Number 25893294
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Virology
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

NOMURA Takushi  国立感染症研究所, その他部局等, 研究員 (80711001)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsエイズウイルス / サルエイズモデル / 新規CTLエピトープ決定 / CTL逃避変異選択 / 複製抑制維持 / 宿主免疫応答 / 免疫動態解析 / 複製制御維持機構解析 / CTL逃避変異 / 国際情報交換
Outline of Final Research Achievements

CTL epitopes Nef9-19, Nef89-97 and Nef193-203 restricted by MHC-I haplotype 90-120-Ia were newly identified by using SIV infected Burmese rhesus macaque AIDS model in this research. A group of macaques that control SIV replication for more than 2 years showed multiple nef mutations including those escaping from Nef9-19 and Nef89-97 epitope-specific CTL responses at 2 years post SIV challenge. However, almost no mutation was observed in Nef193-203 epitopes, suggesting that Nef193-203 epitope-specific CTL responses may maintain efficacy of SIV suppression in this group. Moreover, Nef193-203 specific CTL responses were detected in almost all animals at 2 years post challenge. Thus, Nef193-203 specific CTL responses may contribute to sustained viremia control in SIV controllers.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • Research Products

    (9 results)

All 2014 2013 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Identification of SIV Nef CD8(+) T cell epitopes restricted by a MHC class I haplotype associated with lower viral loads in a macaque AIDS model.2014

    • Author(s)
      Nomura T, Yamamoto H, Takahashi N, Naruse TK, Kimura A, Matano T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 450 Issue: 2 Pages: 942-947

    • DOI

      10.1016/j.bbrc.2014.06.072

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vaccine-induced CD107a+ CD4+ T cells are resistant to depletion following AIDS virus infection2014

    • Author(s)
      Kazutaka Terahara, Hiroshi Ishii, Takushi Nomura, Naofumi Takahashi, Akiko Takeda, Teiichiro Shiino, Yasuko Tsunetsugu-Yokota, and Tetsuro Matano
    • Journal Title

      J. Virol.

      Volume: 88 Issue: 24 Pages: 14232-14240

    • DOI

      10.1128/jvi.02032-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Control of SIV replication by vaccine-induced Gag- and Vif-specific CD8+ T cells2014

    • Author(s)
      Nami Iwamoto, Naofumi Takahashi, Sayuri Seki, Takushi Nomura, Hiroyuki Yamamoto, Makoto Inoue, Tsugumine Shu, Taeko K. Naruse, Akinori Kimura, and Tetsuro Matano
    • Journal Title

      J. Virol.

      Volume: 88 Issue: 1 Pages: 425-433

    • DOI

      10.1128/jvi.02634-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Limited impact of passive non-neutralizing antibody immunization in acute SIV infection on viremia control in rhesus macaques2013

    • Author(s)
      Taku Nakane, Takushi Nomura, Shoi Shi, Midori Nakamura, Taeko K. Naruse, Akinori Kimura, Tetsuro Matano, and Hiroyuki Yamamoto
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 9 Pages: e73453-e73453

    • DOI

      10.1371/journal.pone.0073453

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Lasting SIV control by multiple Gag, Vif, and Nef epitope-specific CD8+ T cells2014

    • Author(s)
      Takushi Nomura, Hiroyuki Yamamoto and Tetsuro Matano
    • Organizer
      32ND ANNUAL SYMPOSIUM ON NONHUMAN PRIMATE MODELS FOR AIDS
    • Place of Presentation
      Portland, Oregon, USA
    • Year and Date
      2014-11-11 – 2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Broadening of CD8+ T-cell targets precedes accumulation of proviral escape mutations in SIV controllers2014

    • Author(s)
      Takushi Nomura, Hiroyuki Yamamoto and Tetsuro Matano
    • Organizer
      The 15th KUMAMOTO AIDS Seminar
    • Place of Presentation
      Aso, Kumamoto
    • Year and Date
      2014-10-01 – 2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Association between broadening of CD8+ T-cell targets and accumulation of proviral escape mutations in SIV controllers2014

    • Author(s)
      Takushi Nomura, Hiroyuki Yamamoto and Tetsuro Matano
    • Organizer
      Keystone simposia "HIV Vaccines: Adaptive Immunity and Beyond (X3)"
    • Place of Presentation
      Banff, Canada
    • Related Report
      2013 Annual Research Report
  • [Presentation] SIV感染制御群における制御維持へのVifおよびNef特異的細胞傷害性Tリンパ球反応の関与に関する研究2013

    • Author(s)
      野村拓志、俣野哲朗
    • Organizer
      第61回ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Remarks] 国立感染症研究所エイズ研究センター第一研究グループ、第二研究グループ publications

    • URL

      http://square.umin.ac.jp/arc/Matano_Research_Group_JP/Publications.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-09-12   Modified: 2019-07-29  

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