| Project/Area Number |
25893294
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
NOMURA Takushi 国立感染症研究所, その他部局等, 研究員 (80711001)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | エイズウイルス / サルエイズモデル / 新規CTLエピトープ決定 / CTL逃避変異選択 / 複製抑制維持 / 宿主免疫応答 / 免疫動態解析 / 複製制御維持機構解析 / CTL逃避変異 / 国際情報交換 |
|---|
| Outline of Final Research Achievements |
CTL epitopes Nef9-19, Nef89-97 and Nef193-203 restricted by MHC-I haplotype 90-120-Ia were newly identified by using SIV infected Burmese rhesus macaque AIDS model in this research. A group of macaques that control SIV replication for more than 2 years showed multiple nef mutations including those escaping from Nef9-19 and Nef89-97 epitope-specific CTL responses at 2 years post SIV challenge. However, almost no mutation was observed in Nef193-203 epitopes, suggesting that Nef193-203 epitope-specific CTL responses may maintain efficacy of SIV suppression in this group. Moreover, Nef193-203 specific CTL responses were detected in almost all animals at 2 years post challenge. Thus, Nef193-203 specific CTL responses may contribute to sustained viremia control in SIV controllers.
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