Study of coagulation and thrombogenic system via the coagulation factor and the its new receptor.

• Project/Area Number: 25893300
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: General pharmacology
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: FUJITA YOSHIKO 独立行政法人国立循環器病研究センター, 研究所, 研究員 (30416218)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 血管 / 血液

Outline of Final Research Achievements

The purpose of this study is to elucidate the new mechanism of blood coagulation system. In this study, the interaction of coagulation factor A and the its new receptor B caused acceleration of thrombin production and blood coagulation by the serial measurement of thrombin activation in normal human plasma and reconstitution system.
We have unraveled the new mechanism which accelerates the activation of coagulation system. It was a chance to rethink of the physiological and pathophysiological mechanism of hemostasis-thrombus-coagulation. We expect that this study will find the resolution key to pathological coagulation thrombus.

Research Products

• [Journal Article] Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor. (2015)
  • Author(s): Yamamoto K, Kakino A, Takeshita H, Hayashi N, Li L, Nakano A, Hanasaki-Yamamoto H, Fujita Y, Imaizumi Y, Toyama-Yokoyama S, Nakama C, Kawai T, Takeda M, Hongyo K, Oguro R, Maekawa Y, Itoh N, Takami Y, Onishi M, Takeya Y, Sugimoto K, Kamide K, Nakagami H, Ohishi M, Kurtz TW, Sawamura T, Rakugi H.
  • Journal Title: FASEB J. Volume: ahead of print
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian and Japanese men. (2013)
  • Author(s): Okamura T, Sekikawa A, Sawamura T, Kadowaki T, Barinas-Mitchell E, Mackey RH, Kadota A, Evans RW, Edmundowicz D, Higashiyama A, Nakamura Y, Abbott RD, Miura K, Fujiyoshi A, Fujita Y, Murakami Y, Miyamatsu N, Kakino A, Maegawa H, Murata K, Horie M, Mitsunami K, Kashiwagi A, Kuller LH, Ueshima H
  • Journal Title: Atherosclerosis Volume: 229 Issue: 1 Pages: 240-245
  • DOI: 10.1016/j.atherosclerosis.2013.04.023
  • NAID: 130004782561
  • Peer Reviewed
• [Journal Article] Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Plays an Important Role in Vascular Inflammation in Current Smokers (2013)
  • Author(s): 180. Takanabe-Mori, R., Ono, K., Wada, H., Takaya, T., Ura, S., Yamakage, H., Satoh-Asahara, N., Shimatsu, A., Takahashi, Y., Fujita, M., Fujita, Y., Sawamura, T. and Hasegawa, K.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 20 Issue: 6 Pages: 585-590
  • DOI: 10.5551/jat.16436
  • NAID: 130004845439
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed