| Project/Area Number |
25893302
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Cardiovascular medicine
|
|---|
| Research Institution | National Cardiovascular Center Research Institute |
|---|
Principal Investigator |
SAKAMOTO Shingo 独立行政法人国立循環器病研究センター, 病院, 医師 (30713846)
|
|---|
| Project Period (FY) |
2013-08-30 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 循環器 / 画像 / 末梢動脈疾患 / 光干渉断層法 / 下肢動脈硬化性疾患 |
|---|
| Outline of Final Research Achievements |
We here assessed the peripheral vascular response to stents in the superficial femoral artery on optical coherence tomography (OCT). The subjects consisted of 9 stents of 7 patients with peripheral artery disease who had previously received bare-metal stents in the superficial femoral artery. The time from stent implantation to OCT was relatively early (≤15 months) in 7 self-expandable stents and very late (>10 years) in 2 balloon-expandable stents. Low intensity area around stent struts was observed in all stents in the relatively early phase. Stimulus on the vessel wall from the self-expandable stent might cause prolonged vessel injury, resulting in the manifestation of low intensity area around stent struts.
Lipid-rich intima and calcification were observed within stents in the very late phase on OCT and pathological evaluation, suggesting that newly formed atherosclerotic lesions within neointimal tissues can occur during a prolonged period after stent implantation.
|
