EVALUATION OF PERINIDAL CEREBRAL BLOOD FLOW AND METABOLISM USING A NOVEL QUANTITATIVE 15O-PET METHOD IN PATIENTS WITH ARTERIOVENOUS MALFORMATION

• Project/Area Number: 25893304
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Neurosurgery
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: MARUYAMA DAISUKE 独立行政法人国立循環器病研究センター, 病院, 医師 (70713840)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 脳動静脈奇形 / 脳循環代謝 / 15O標識ガス吸入PET / 脳神経疾患 / 機能的賦活

Outline of Final Research Achievements

Assuming a fixed fractionation may introduce systematic errors when imaging pathologic tissues, such as in patients with arteriovenous malformation (AVM), a disorder often characterized by increased arterial blood volume. In AVM patients, we compared the quantitative values of 15O-PET parameters derived using the present a dual-tracer basis function method (DBFM), which avoid the need to assume a fixed fractionation of blood volume as being arterial and venous, and those derived using the previously proposed dual-tracer autoradiography (DARG) methods.
We observed a higher positive correlation between the DBFM method and DARG method in remote ROI than in perinidal ROI.In perinidal ROI, quantitative values of rCBF and rCMRO2 tended to be overestimated more when using DARG than when using DBFM.Our findings demonstrate the validity of the present DBFM method as a possible way to more accurately evaluate perinidal regions in AVM patients.

Research Products

• [Journal Article] 15O標識ガス吸入PETを用いた脳動静脈奇形における新たな循環代謝評価の可能性 (2015)
  • Author(s): 丸山大輔、中川原譲二、飯田秀博、越野一博、森田奈緒美、安部倉友、濱野栄佳、佐藤徹、片岡大治、飯原弘二、髙橋淳
  • Journal Title: The 33rd Meeting of the Mt. Fuji Workshop on CVD 「脳卒中における脳循環代謝画像のすべてー初心者からエキスパートまでー」 Volume: 33
• [Presentation] EVALUATION OF PERINIDAL CEREBRAL BLOOD FLOW AND METABOLISM USING A NOVEL QUANTITATIVE 15O-PET METHOD IN PATIENTS WITH ARTERIOVENOUS MALFORMATION (2015)
  • Author(s): Daisuke Maruyama, Jyoji Nakagawara, Hidehiro Iida, Kazuhiro Koshino, Naomi Morita, Tetsu Satow, Hiroharu Kataoka, Koji Iihara, Jun Takahashi
  • Organizer: Brain 2015
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2015-06-27 – 2015-06-30
• [Presentation] 脳動静脈奇形における15O 標識ガス吸入PETを用いた新たな循環代謝評価についての検討 (2015)
  • Author(s): 丸山 大輔, 中川原 譲 , 飯田 秀博 , 越野 一博, 森田 奈緒美, 佐藤 徹, 片岡 大治 , 飯原 弘二, 高橋 淳
  • Organizer: 脳卒中の外科学会総会
  • Place of Presentation: 広島
  • Year and Date: 2015-03-26 – 2015-03-29
• [Presentation] 15O標識ガス吸入PETを用いた 脳動静脈奇形における 新たな循環代謝評価の可能性 (2014)
  • Author(s): 丸山 大輔, 中川原 譲二, 飯田 秀博, 越野 一博, 森田 奈緒美,安部倉 友, 濱野 栄佳 , 佐藤 徹 , 片岡 大治 , 飯原 弘二, 高橋 淳
  • Organizer: 第26回 日本脳循環代謝学会総会
  • Place of Presentation: 岡山
  • Year and Date: 2014-11-21 – 2014-11-22
• [Presentation] 15O標識ガス吸入PETを用いた 脳動静脈奇形における 新たな循環代謝評価の可能性 (2014)
  • Author(s): 丸山 大輔, 中川原 譲二 , 飯田 秀博 , 越野 一博 , 安部倉 友, 濱野 栄佳 , 佐藤 徹 , 片岡 大治 , 飯原 弘二, 高橋 淳
  • Organizer: Mt. Fuji Workshop on CVD
  • Place of Presentation: 盛岡
  • Year and Date: 2014-08-30
• [Presentation] もやもや病における123I-IMP SPECTと15O標識ガス吸入PETによる代償能評価 (2013)
  • Author(s): 丸山大輔、中川原譲二、森田奈緒美、堀祐樹、飯田秀博、山内圭太、石井大造、小林紀方、森田健一、佐藤徹、片岡大治、飯原弘二
  • Organizer: 第25回日本脳循環代謝学会総会
  • Place of Presentation: 京王プラザホテル札幌（北海道）