| Budget Amount *help |
¥195,130,000 (Direct Cost: ¥150,100,000、Indirect Cost: ¥45,030,000)
Fiscal Year 2018: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥26,130,000 (Direct Cost: ¥20,100,000、Indirect Cost: ¥6,030,000)
Fiscal Year 2015: ¥61,880,000 (Direct Cost: ¥47,600,000、Indirect Cost: ¥14,280,000)
Fiscal Year 2014: ¥73,840,000 (Direct Cost: ¥56,800,000、Indirect Cost: ¥17,040,000)
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| Outline of Final Research Achievements |
Intestinal mucosa is always activated so that all epithelial cells are replaced in approximately one week. Intestinal stem cells supply intestinal epithelial cells to keep normal mucosa by orderly differentiation system. When the control collapses, it becomes the ulcer, resulting in bleeding and infection. Especially, intractable ulceration is often shown in the patients with inflammatory bowel disease (IBD) whose number are increased in Japan. The treatment for the ulcer has however not been established. In this study, our original culturing system of human intestinal epithelial cells as organoids led to clarify the molecular mechanisms for stem cell dysfunction under chronic inflammation and for stem cell regeneration against inflammation. These results might be useful for the development of novel drugs targeting mucosal healing in IBD.
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