GWAS-based analysis of molecular basis of AhR developmental neurotoicity.
| Project/Area Number |
26241016
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Waseda University (2015-2016)
Nagasaki University (2014) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
若菜 茂晴 国立研究開発法人理化学研究所, その他部局等, その他 (90192434)
西谷 正太 長崎大学, 医歯薬学総合研究科(医学系), 助教 (50448495)
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| Research Collaborator |
BENNER Seico
KIMURA Eiki
ENDO Nozomi
UJITA Waka
ENDO Toshihiro
OKADA Aya
MAKINO Yusuke
KYOSO Kazuki
TODORIKI Hiroe
MAEKAWA Fumihiko
TOHYAMA Chiharu
OYAMA Hiroshi
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥40,170,000 (Direct Cost: ¥30,900,000、Indirect Cost: ¥9,270,000)
Fiscal Year 2016: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2015: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2014: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
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| Keywords | 神経科学 / 社会医学 / トランスレーショナルリサーチ / 有害化学物質 / 行動神経内分泌学 / 行動神経科学 / 遺伝子 |
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| Outline of Final Research Achievements |
Maternal exposure to a low dose of dioxin in rodents have been reported to disrupt high cognitive and socio-emotional functions of offspring even in a dose. We have also reported that the mice who exhibited abnormal socio-emotional behaviors after dioxin exposure showed the imbalanced brain activities between medial prefrontal cortex and amygdala. Consistently, a human birth cohort study indicated a low-level of prenatal exposure to dioxin-like PCB exhibited a preference for the upright biological motion (BM) over inverted BM, indicating that prenatal exposure to dioxin like compounds impairs the development of social functioning. Although it is well known that dioxin affect lethal, teratogenic and immuno- toxicities via the aryl hydrocarbon receptor (AhR), it is unclear yet whether such AhR signaling is involved in developmental neurotoxicity. We also found that AhR have an important role in brain function.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Developmental origin of abnormal dendritic growth in the mouse brain induced by in utero disruption of aryl hydrocarbon receptor signaling.2015
Author(s)
Eiki Kimura, Ken-ichiro Kubo, Chieri Matsuyoshi, Seico Benner, Mayuko Hosokawa, Toshihiro Endo, Wenting Ling, Masanobu Kohda, Kazuhito Yokoyama, Kazunori Nakajima, Masaki Kakeyama, and Chiharu Tohyama.
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Journal Title
Neurotoxicol. Teratol.
Volume: 52
Pages: 42-50
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Neuronal heterotopias affect the activities of distant brain areas and lead to behavioral deficits2015
Author(s)
Kazuhiro Ishii, Ken-ichiro Kubo, Toshihiro Endo, Keitaro Yoshida, Seico Benner, Yukiko Ito, Hidenori Aizawa, Michihiko Aramaki, Akihiro Yamanaka, Kohichi Tanaka, Norio Takata, Kenji Tanaka, Masaru Mimura, Chiahru Tohyama, Masaki Kakeyama, and Kazunori Nakajima
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Journal Title
Journal of Neuroscience
Volume: 35
Issue: 36
Pages: 12432-45
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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