Terahertz-Raman circular dichroic spectroscopy for chiral higher order conformation of macromolecules, and its manipulation by intense terahertz wave

• Project/Area Number: 26246037
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General applied physics
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Hoshina Hiromichi 国立研究開発法人理化学研究所, 光量子工学研究領域, 上級研究員 (10419004)
• Co-Investigator(Kenkyū-buntansha): 山本 茂樹 大阪大学, 理学研究科, 助教 (60552784)
• Co-Investigator(Renkei-kenkyūsha): SUZIKI Hal 国立研究開発法人理化学研究所, 光量子工学研究領域, 研究員 (50633559)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥42,510,000 (Direct Cost: ¥32,700,000、Indirect Cost: ¥9,810,000); Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000); Fiscal Year 2014: ¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000)
• Keywords: テラヘルツ分光 / 低周波数ラマン分光 / 円偏光二色性分光 / 対掌性 / キラリティ / 高分子 / 高次構造 / 円偏光二色性 / ラマン光学活性 / 分光 / テラヘルツ

Outline of Final Research Achievements

In this research, terahertz (THz) vibrational circular dichroism (VCD) and very low frequency Raman optical activity (ROA) were developed for studying chiral vibrations of higher order conformation of macromolecules. Low-frequency ROA spectra of chiral molecules such as 2-phenyl-propion acid and poly-alanine were measured and compared with the result of quantum calculation, which reveals that the chiral vibration of whole molecular motion appears in the low frequency region. Also, aiming to control the chirality of macromolecules, high-power THz wave was irradiated for polymer solution. The conformational change of polymer sample was observed after irradiating high-power THz wave generated by THz free electron laser.

Research Products

• [Journal Article] Three different kinds of weak C-H...O=C inter- and intramolecular interactions in poly( ε -caprolactone) studied by using terahertz spectroscopy, infrared spectroscopy and quantum chemical calculations (2018)
  • Author(s): Funaki Chihiro、Yamamoto Shigeki、Hoshina Hiromichi、Ozaki Yukihiro、Sato Harumi
  • Journal Title: Polymer Volume: 137 Pages: 245-254
  • DOI: 10.1016/j.polymer.2018.01.025
  • Peer Reviewed
• [Journal Article] Low-Frequency Vibrational Modes of Poly(glycolic acid) and Thermal Expansion of Crystal Lattice Assigned On the Basis of DFT-Spectral Simulation Aided with a Fragment Method (2017)
  • Author(s): Shigeki Yamamoto, Mai Miyada, Harumi Sato, Hiromichi Hoshina, and Yukihiro Ozaki
  • Journal Title: J. Phys. Chem. B Volume: 121 Issue: 5 Pages: 1128-1138
  • DOI: 10.1021/acs.jpcb.6b11304
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Establishing the link between fibril formation and Raman optical activity spectra of insulin (2017)
  • Author(s): Kessler Jiri、Yamamoto Shigeki、Bour Petr
  • Journal Title: Physical Chemistry Chemical Physics Volume: 19 Issue: 21 Pages: 13614-13621
  • DOI: 10.1039/c7cp01556a
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] テラヘルツ光照射で誘起される 高分子構造の変化 (2017)
  • Author(s): 保科宏道
  • Journal Title: 化学工業 Volume: 68 Pages: 195-201
  • Acknowledgement Compliant
• [Journal Article] Polymer Morphological Change Induced by Terahertz Irradiation (2016)
  • Author(s): 4.Hiromichi Hoshina, Hal Suzuki, Chiko Otani, Masaya Nagai, Keigo Kawase, Akinori Irizawa, Goro Isoyama
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 27180-27180
  • DOI: 10.1038/srep27180
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Macromolecular Structures Investigated by Terahertz Waves (2017)
  • Author(s): H. Hoshina
  • Organizer: MTSA2017
  • Int'l Joint Research / Invited
• [Presentation] Observation and manipulation of polymer structures by terahertz wave (2017)
  • Author(s): Hiromichi Hoshina and Chiko Otani
  • Organizer: Russia-Japan-USA-Europe Symposium on Fundamental & Applied Problems of Terahertz Devices & Technologies (RJUSE TeraTech-2017)
  • Int'l Joint Research / Invited
• [Presentation] Application of Terahertz Waves for Polymer Science (2017)
  • Author(s): H. Hoshina
  • Organizer: The 6th Internationak Symposium on Organic and Inorganic Electronic Materials and Related Nanotechnologies (EM-NANO 2017)
  • Int'l Joint Research / Invited
• [Presentation] Potential of THz waves for manipulating macromolecular structure (2017)
  • Author(s): H. Hoshina
  • Organizer: THz Mansion Meeting The Vandervilt Grace Hotel, Newport, RI, USA
  • Int'l Joint Research / Invited
• [Presentation] テラヘルツ光による高分子構造の解明と操作 (2016)
  • Author(s): 保科宏道
  • Organizer: 応用物理学会・量子エレクトロニクス研究会「光-物質相互制御 ～制御技術の進展と新しい物理の探求～」
  • Place of Presentation: 上智大学軽井沢セミナーハウス，長野県北佐久郡軽井沢町
  • Year and Date: 2016-12-08
  • Invited
• [Presentation] Application of Terahertz Wave for Polymer Science (2016)
  • Author(s): Hiromichi Hoshina
  • Organizer: JTMSIS (Japan-Taiwan Medical Spectroscopy International Symposium)
  • Place of Presentation: Awaji Island, Japan
  • Year and Date: 2016-12-04
  • Int'l Joint Research / Invited
• [Presentation] テラヘルツ光による高分子高次構造の解明と操作 (2016)
  • Author(s): 保科宏道
  • Organizer: シンポジウム「テラヘルツ科学の最先端III」
  • Place of Presentation: 三国観光ホテル，福井県坂井市
  • Year and Date: 2016-11-23
  • Invited
• [Presentation] Application of terahertz waves for polymer science (2016)
  • Author(s): Hiromichi Hoshina
  • Organizer: SPIE Photonics Asia 2016
  • Place of Presentation: Beijing, China
  • Year and Date: 2016-10-12
  • Int'l Joint Research / Invited
• [Presentation] Altering Polymer Morphology by Intense Terahertz Wave Irradiation (2016)
  • Author(s): Hiromichi Hoshina, Hal Suzuki, Chiko Otani, Masaya Nagai, Keigo Kawase, Akinori Irizawa, Goro Isoyama
  • Organizer: 41th IRMMW-THz 2016
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2016-09-25
  • Int'l Joint Research
• [Presentation] Polymer Morphological Change Induced by Terahertz Irradiation (2016)
  • Author(s): Hiromichi. Hoshina, Hal Suzuki, Chiko Otani, Masaya Nagai, Keigo Kawase, Akinori Irizawa, Goro Isoyama
  • Organizer: 5th EOS Topical Meeting on Terahertz Science & Technology
  • Place of Presentation: Pecs, Hungary
  • Year and Date: 2016-05-08
  • Int'l Joint Research
• [Presentation] テラヘルツ光による高分子構造の解明と操作 (2016)
  • Author(s): 保科宏道
  • Organizer: 第4回「光量子工学研究」
  • Place of Presentation: 埼玉県和光市
  • Invited
• [Presentation] Observation and Manipulation of Macromolecules by Terahertz Waves (2016)
  • Author(s): Hiromichi Hoshina
  • Organizer: 第77回応用物理学会秋季学術講演会
  • Place of Presentation: 朱鷺メッセ，新潟市
  • Invited
• [Presentation] Polymer Morphology Studied by Terahertz Sepctroscopy (2015)
  • Author(s): 1.H. Hoshina, H. Suzuki, C. Otani, S. Yamamoto, H. Sato, Y. Ozaki
  • Organizer: The Second International Symposium on Frontiers in THz Technology (FTT2015)
  • Place of Presentation: Congress Center in ACT city, Hamamatsu, Japan
  • Year and Date: 2015-09-01
  • Int'l Joint Research / Invited
• [Presentation] Monitoring Hydrogen Bonds in Soft Materials by Terahertz Spectroscopy (2015)
  • Author(s): 2.H. Hoshina, H. Suzuki, C. Otani, S. Yamamoto, S. Yajima, Y. Ozaki
  • Organizer: 3rd International Symposium on Microwave/THz Science and Application (MTSA)
  • Place of Presentation: OIST, Okinawa, Japan
  • Year and Date: 2015-07-03
  • Int'l Joint Research / Invited
• [Presentation] Higher order structure of macromolecules studied by Terahertz spectroscopy (2014)
  • Author(s): 3.Hiromichi Hoshina, Hal Suzuki, Shigeki Yamamoto, Yukihiro Ozaki, Setsuko Yajima, and Chiko Otani
  • Organizer: SPIE Photonics Asia
  • Place of Presentation: Beijing International Convention Center, Beijing China
  • Year and Date: 2014-10-09
  • Int'l Joint Research / Invited
• [Presentation] Higher Order Structure of Polymers Studied by Terahertz Spectroscopy (2014)
  • Author(s): Hiromichi Hoshina
  • Organizer: 8th International Conference on Broadband Dielectric Spectroscopy and its Applications
  • Place of Presentation: Wisla, Poland,
  • Year and Date: 2014-09-15
  • Int'l Joint Research / Invited
• [Book] Calculation of Vibrational Spectra of Large Molecules from Their Fragments Calculation of Vibrational Spectra of Large Molecules from Their Fragments (2018)
  • Author(s): Shigeki Yamamoto and Petr Bour
  • Total Pages: 26
  • Publisher: Springer