Mechanisms for neuroblast migration in the maintenance and regeneration of postnatal brain tissue
Project/Area Number |
26250019
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Nagoya City University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
KANEKO Naoko 名古屋市立大学, 大学院医学研究科, 講師 (20464571)
SAWADA Masato 名古屋市立大学, 大学院医学研究科, 助教 (20645288)
|
Research Collaborator |
JINNOU Hideo
FUJIKAKE Kazuma
FUJIOKA Teppei
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥30,160,000 (Direct Cost: ¥23,200,000、Indirect Cost: ¥6,960,000)
Fiscal Year 2016: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2015: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2014: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
|
Keywords | 再生医学 / 神経科学 / 脳・神経 / 脳神経疾患 / 神経化学 / 脳 / ニューロン新生 / 細胞移動 / 再生 |
Outline of Final Research Achievements |
We have studied 1) the expression and function ofβ1integrin in migrating neuroblasts for their efficient chain migration along the blood vessel scaffolds, 2) morphological changes of neuroblasts during migration termination and their molecular mechanisms, 3) olfactory-input dependent mechanisms for neuronal integration and maturation, and 4) neuronal regeneration and functional recovery promoted by neuronal migration.
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain2017
Author(s)
Fujioka T,Kaneko N, Ajioka I, Nakaguchi K, Omata T, Ohba H, Fassler R, Garcia-Verdugo JM, Sekiguchi K, Matsukawa N, Sawamoto K
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Journal Title
EbioMedicine
Volume: 16
Pages: 195-203
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Genome-Wide Association Study Identifies ZNF354C Variants Associated with Depression from Interferon-Based Therapy for Chronic Hepatitis C2016
Author(s)
Matsunami K, Nishida N, Kaneko N, Ikeo K, Licht Toyo-oka, Takeuchi H, Matsuura K, Tamori A, Nomura H, Yoshiji H, Imamura M, Masaki N, Hayakawa T, Ide T, Shimada N, Ikeda F, Hino K, Nishiguchi S, Okuse C, Nojiri S, Sawamoto K, Tokunaga K, Joh T, Tanaka
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Journal Title
PLoS One
Volume: 11
Issue: 10
Pages: 1-18
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Book] 麻酔2015
Author(s)
藤掛数馬 , 太田晴子, 祖父江和哉, 澤本和延
Total Pages
8
Publisher
克誠堂出版
Related Report
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[Book] 脳科学事典2015
Author(s)
金子奈穂子, 澤本和延
Total Pages
1
Publisher
日本神経科学学会 脳科学辞典編集委員会
Related Report
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[Book] 日本臨休2015
Author(s)
澤本和延, 金子奈穂子
Total Pages
5
Publisher
日本臨牀社
Related Report
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