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Prevention, diagnosis and drug discovery of aging diseases using Pin1 related molecules

Research Project

Project/Area Number 26252064
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied molecular and cellular biology
Research InstitutionTokyo Kasei University (2018-2019)
Tohoku University (2014-2017)

Principal Investigator

Uchida Takafumi  東京家政大学, 生活科学研究所, 研究員 (80312239)

Co-Investigator(Kenkyū-buntansha) 内田 千代子  福島大学, 子どものメンタルヘルス支援事業推進室, 客員教授 (80312776)
今村 博臣  京都大学, 生命科学研究科, 准教授 (20422545)
Project Period (FY) 2014-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000)
Fiscal Year 2018: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2017: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2016: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2015: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2014: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywordsプロリン異性化酵素 / Pin1 / Gas7 / FRET / 癌 / アルツハイマー病 / ポリフェノール / tau / Myc / 健康長寿 / 肥満 / 血小板 / 心臓疾患 / 幹細胞 / 酵素 / 再生医学 / 脳神経疾患 / 食品 / 加齢疾患 / 骨粗鬆症 / 微小管 / シグナル伝達 / 硝酸 / FOXO3 / MDR / AMPK / 生体機能利用 / Gas7b / Tau / NO / 蛋白質 / 可視化
Outline of Final Research Achievements

We elucidated the details of the mechanism by which Pin1 and Gas7 suppress the onset, malignant transformation, or suppression of cancer, Alzheimer's disease (AD), diabetes, etc., and created the basis for applying these molecules to prevention, diagnosis, and treatment. Moreover, it was clarified that Pin1 promotes the differentiation of stem cells, and it was shown to be useful for infertility treatment and regenerative medicine. Since Pin1 is involved in the signal transduction of both phosphorylation and nitric oxide in the cell, we constructed a method to image this signal transduction in real time. We also showed that seaweed polyphenols that inhibit Pin1 activity prevent obesity and lifestyle-related diseases.

Academic Significance and Societal Importance of the Research Achievements

Pin1は、鼻咽腔癌でATF1、髄芽腫でGli1、多種類の癌でFOXO3の転写活性を制御し癌の発症・治療に、AMPK、MAPK、CaMKIIの酵素活性制御により、糖尿病、心疾患、アルツハイマー病(AD)に関与することを解明した。間葉系幹細胞、巨核球前駆細胞、精子幹細胞の分化促進機構を解明した。類似分子のGas7はADの病理であるタウ線維化を抑制することを示した。Pin1構造変化解析系として、c-Myc、TauおよびNO(硝酸・亜硝酸)濃度をイメージングするFRET解析法を構築した。食品中ポリフェノール類のカテキンや藻類ポリフェノール、味噌はPin1活性制御することを解明した。

Report

(6 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (68 results)

All 2020 2019 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (3 results) Journal Article (26 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 25 results,  Open Access: 20 results,  Acknowledgement Compliant: 4 results) Presentation (35 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Remarks (4 results)

  • [Int'l Joint Research] University of Michigan Medical School(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Guangdong Medical University(China)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Seoul National University/Sungkyunkwan University(韓国)

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Growth arrest specific protein 7 inhibits tau fibrillogenesis.2020

    • Author(s)
      Shimizu, T., Hirose, K., Uchida, C., Uchida, T.
    • Journal Title

      Biochem Biophy Res Commun,

      Volume: 526 Issue: 2 Pages: 281-286

    • DOI

      10.1016/j.bbrc.2020.03.041

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolyl Isomerase Pin1 Directly Regulates Calcium/Calmodulin-Dependent Protein Kinase II Activity in Mouse Brains2018

    • Author(s)
      Shimizu Taiki、Kanai Kenta、Sugawara Yui、Uchida Chiyoko、Uchida Takafumi
    • Journal Title

      Frontiers in Pharmacology

      Volume: 9 Pages: 1351-1351

    • DOI

      10.3389/fphar.2018.01351

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fluorescent resonance energy transfer -based biosensor for detecting conformational changes of Pin12018

    • Author(s)
      Hidaka Masafumi、Okabe Emiko、Hatakeyama Kodai、Zook Heather、Uchida Chiyoko、Uchida Takafumi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 505 Issue: 2 Pages: 399-404

    • DOI

      10.1016/j.bbrc.2018.09.123

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1.2018

    • Author(s)
      Hidaka M, Kosaka K, Tsushima S, Uchida C, Takahashi K, Takahashi N, Tsubuki M, Hara Y, Uchida T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 499 Issue: 3 Pages: 681-687

    • DOI

      10.1016/j.bbrc.2018.03.212

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of human mutant cyclin dependent kinase 4, Cyclin D and telomerase extends the life span but does not immortalize fibroblasts derived from loggerhead sea turtle (Caretta caretta).2018

    • Author(s)
      Fukuda T, Eitsuka T, Donai K, Kurita M, Saito T, Okamoto H, Kinoshita K, Katayama M, Nitto H, Uchida T, Onuma M, Sone H, Inoue-Murayama M, Kiyono T.
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 9229-9229

    • DOI

      10.1038/s41598-018-27271-x

    • NAID

      120006979734

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prolyl isomerase Pin1 is required sperm production by promoting mitosis progression of spermatogonial stem cells.2018

    • Author(s)
      Kurita-Suzuki A, Kamo Y, Uchida C, Tanemura K, Hara K, Uchida T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 497 Issue: 1 Pages: 388-393

    • DOI

      10.1016/j.bbrc.2018.02.090

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peptidyl-Prolyl Isomerase 1 Regulates Ca(2+) Handling by Modulating Sarco(Endo)Plasmic Reticulum Calcium ATPase and Na(2+)/Ca(2+) Exchanger 1 Protein Levels and Function.2017

    • Author(s)
      Sacchi V, Wang BJ, Kubli D, Martinez AS, Jin JK, Alvarez R Jr, Hariharan N, Glembotski C, Uchida T, Malter JS, Yang Y, Gross P, Zhang C, Houser S, Rota M, Sussman MA
    • Journal Title

      J Am Heart Assoc

      Volume: 493 Issue: 10

    • DOI

      10.1161/jaha.117.006837

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prolyl isomerase Pin1 promotes proplatelet formation of megakaryocytes via tau2017

    • Author(s)
      Shimizu Taiki、Uchida Chiyoko、Shimizu Ritsuko、Motohashi Hozumi、Uchida Takafumi
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 493 Issue: 2 Pages: 946-951

    • DOI

      10.1016/j.bbrc.2017.09.115

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis2017

    • Author(s)
      Xu Tao、Zhang Honglai、Park Sung-Soo、Venneti Sriram、Kuick Rork、Ha Kimberly、Michael Lowell Evan、Santi Mariarita、Uchida Chiyoko、Uchida Takafumi、Srinivasan Ashok、Olson James M.、Dlugosz Andrzej、Camelo-Piragua Sandra、Rual Jean-Fransois
    • Journal Title

      Neoplasia

      Volume: 19 Issue: 3 Pages: 216-225

    • DOI

      10.1016/j.neo.2017.01.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Brown Algae polyphenol, a prolyl isomerase Pin1 inhibitor, prevents obesity by inhibiting the differentiation of stem cells into adipocytes.2016

    • Author(s)
      Suzuki A, Saeki T, Ikuji H, Uchida C, Uchida T
    • Journal Title

      Plos One

      Volume: 11(12) Issue: 12 Pages: e0168830-e0168830

    • DOI

      10.1371/journal.pone.0168830

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Protein Level and Transcription Activity of Activating Transcription Factor 1 is Regulated by Prolyl-isomerase Pin1 in Nasopharyngeal Carcinoma Progression.2016

    • Author(s)
      Huang GL, Liao D, Chen H, Lu Y, Chen L, Li H, Li B, Liu W, Ye C, Li T, Zhu Z, Wang J, Uchida T, Zou Y, Don Z, He Z
    • Journal Title

      Cell Death Dis

      Volume: 7(12) Issue: 12 Pages: e2571-e2571

    • DOI

      10.1038/cddis.2016.349

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 白血病治療薬剤ATRAの新規標的分子、プロリン異性化酵素Pin12016

    • Author(s)
      高橋勝彦、内田千代子、内田隆史
    • Journal Title

      血液内科

      Volume: 73 Pages: 491-486

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Prolyl Isomerase Pin1 Regulates Doxorubicin- Inducible P-glycoprotein Level by Reducing Foxo3 Stability.2016

    • Author(s)
      Shimizu T, Bamba Y, Kawabe Y , Fukuda T, Fujimori F, Takahashi K, Uchida C, and Uchida T
    • Journal Title

      Biochemical Biophysical Research Communications

      Volume: 471 Issue: 2 Pages: 328-333

    • DOI

      10.1016/j.bbrc.2016.02.014

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] sNOOOpy, a Sensor for Physiological NO3-/NO2- Employing a Bacterial Two-Component Regulatory System.2016

    • Author(s)
      Hidaka M, Gotoh A, Shimizu T, Minamisawa K, Imamura H and Uchida T
    • Journal Title

      Journal Biological Chemistry

      Volume: 291 Issue: 5 Pages: 2260-2269

    • DOI

      10.1074/jbc.m115.687632

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mycoplasma pneumonia of swine (MPS) resistance and immune characteristics of pig lines generated by crossing an MPS pulmonary lesion selected Landrace line and a highly immune capacity selected Large White line.2016

    • Author(s)
      Borjigin L, Shimazu T, Katayama Y, Watanabe K, Kitazawa H, Roh SG, Aso H, Katoh K, Uchida T, Suda Y, Sakuma A, Nakajo M, Suzuki K
    • Journal Title

      Animal Science Journal

      Volume: 印刷中 Issue: 8 Pages: 972-981

    • DOI

      10.1111/asj.12529

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunogenic properties of Landrace pigs selected for resistance to mycoplasma pneumonia of swine.2016

    • Author(s)
      Borjigin L, Shimazu T, Katayama Y, Watanabe K, Kitazawa H, Roh S, Aso H, Katoh K, Uchida T, Suda Y, Sakuma A, Nakajo M and Suzuki K
    • Journal Title

      Animal Science Journal

      Volume: 印刷中 Issue: 5 Pages: 638-645

    • DOI

      10.1111/asj.12471

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunogenic properties of Landrace pigs selected for resistance to mycoplasma pneumonia of swine.2016

    • Author(s)
      Borjigin L, Shimazu T, Katayama Y, Li M, Satoh T, Watanabe K, Kitazawa H, Roh S, Aso H, Katoh K, Uchida T, Suda Y, Sakuma A, Nakajo M and Suzuki K
    • Journal Title

      Animal Science Journal

      Volume: 印刷中 Issue: 3 Pages: 321-329

    • DOI

      10.1111/asj.12440

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunit2015

    • Author(s)
      Nakatsu Y, Iwashita M, Sakoda H, Ono H, Nagata K, Matsunaga Y, Fukushima T, Fujishiro M, Kushiyama A, Kamata H, Takahashi S, Katagiri H, Honda H, Kiyonari H, Uchida T, Asano T
    • Journal Title

      J Biol Chem

      Volume: 290 Issue: 40 Pages: 24255-24266

    • DOI

      10.1074/jbc.m115.658559

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pin1 Promotes Neuronal Death in Stroke by Stabilizing Notch Intracellular Domain2015

    • Author(s)
      1.Baik SH, Fane M, Hyung PJ, Cheng YL, Yun UJ, Choi Y, Park JS, Chai B, Park JS, Back aik SH, Fane M, Hyung PJ, Cheng YL, Yun UJ, Choi Y, Park JS, Chai B, Park JS, Back SH, Jeong JI, Jang YJ, Bahn G, Lee JY, Li YI, Sobey C, Uchida T, Park JH, Kim HT, Tang S, Arumugam T and Jo DG.
    • Journal Title

      Ann Neurol

      Volume: 77(3) Issue: 3 Pages: 504-516

    • DOI

      10.1002/ana.24347

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phosphatidylethanolamine plasmalogen enhances the inhibiting effect of phosphatidylethanolamine on γ-secretase activity2015

    • Author(s)
      Tomoko Onodera, Eugene Futai, Eiichiro Kan, Naoki Abe, Takafumi Uchida, Yoshiyuki Kamio and Jun Kaneko
    • Journal Title

      Journal of Biochemistry,156,(2015)]

      Volume: 156 Issue: 5 Pages: 301-309

    • DOI

      10.1093/jb/mvu074

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Neurotensin enhances sperm capacitation and the acrosome reaction in mice.2014

    • Author(s)
      佐藤英明
    • Journal Title

      BIOLOGY OF REPRODUCTION

      Volume: 91(2)53 Issue: 2 Pages: 1-9

    • DOI

      10.1095/biolreprod.113.112789

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The nitrate-sensing NasST system regulates nitrous oxide reductase and periplasmic nitrate reductase in Bradyrhizobium japonicum.2014

    • Author(s)
      Sanchez, C., M. Itakura, T. Okubo, T. Matsumoto, H. Yoshikawa, A. Gotoh, M. Hidaka, T. Uchida, and K. Minamisawa.
    • Journal Title

      Environmental Microbiology

      Volume: 16 Issue: 10 Pages: 3263-3274

    • DOI

      10.1111/1462-2920.12546

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pin1 regulates osteoclast fusion through suppression of the master regulator of cell fusion DC-STAMP.2014

    • Author(s)
      5.Islam R, Bae HS, Yoon WJ, Woo KM, Baek JH, Kim HH, Uchida T, and Ryoo HM
    • Journal Title

      J Cell Physiol,

      Volume: 229 Issue: 12 Pages: 2166-2174

    • DOI

      10.1002/jcp.24679

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A high-throughput screen for inhibitors of the prolyl isomerase, Pin1, identifies a seaweed polyphenol that reduces adipose cell differentiation.2014

    • Author(s)
      Mori T, Hidaka M, Ikuji H, Yoshizawa I, Toyohara H, Okuda T, Uchida C, Asano T, Yotsu-Yamashita M, Uchida T
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 78 Issue: 5 Pages: 832-838

    • DOI

      10.1080/09168451.2014.905189

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of prolyl isomerase Pin1 in pathogenesis of diseases and remedy for the diseases from natural products2014

    • Author(s)
      Takahashi K, Shimizu T, Kosaka K, Hidaka M, Uchida C, and Uchida T
    • Journal Title

      Current Drug Target,

      Volume: 15 Pages: 973-981

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Diversity in ATP concentrations in a single bacterial cell population revealed by quantitative single-cell imaging2014

    • Author(s)
      Hideyuki Yaginuma, Shinnosuke Kawai, Kazuhito V. Tabata, Keisuke Tomiyama, Akira Kakizuka, Tamiki Komatsuzaki, Hiroyuki Noji, and Hiromi Imamura
    • Journal Title

      Scientific Reports

      Volume: 4 Issue: 1 Pages: 6522-6522

    • DOI

      10.1038/srep06522

    • NAID

      120005575159

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Pin1 gene deficient mice impaired spatial cognitive function and showed a decrease of frontotemporal lobar.2019

    • Author(s)
      Ohtaki H eH. OHTAKI1, Y. TANAKA1, T. UCHIDA et al
    • Organizer
      Neuro 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pin1 gene deficient mice impair spatial memory and show small brain volume2019

    • Author(s)
      H. OHTAKI1, Y. TANAKA1, T. UCHIDA et al
    • Organizer
      Society for Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pin 1 gene deficient mice impair spatial cognitive function and increase amyloid formation in the brain2019

    • Author(s)
      大滝博和, 田中優希, 内田隆史 et al
    • Organizer
      日本生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] tau と相互作用する Gas7 の機能解析2018

    • Author(s)
      清水泰希 、藤田彩子、内田隆史
    • Organizer
      日本分子生物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] tau 凝集における Gas7 の役割について2018

    • Author(s)
      清水泰希 、内田隆史
    • Organizer
      au 研究ミーティング
    • Related Report
      2018 Annual Research Report
  • [Presentation] Pin1 and Par14 prolyl isomerase inhibitors block oral cancer cell proliferation2017

    • Author(s)
      H. Miyashita, S Mori, T. Takahashi, T. Uchida
    • Organizer
      oral & maxillofacial surgery
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アミノ酸による脂肪細胞のPin1活性量調節2017

    • Author(s)
      高橋勝彦、片桐啓暁、清水愛、和泉田有望、福田翔大、高橋典子、内田隆史、東伸昭
    • Organizer
      日本生化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Pin1peptidyl prolyl isomerase inhibitors block cancer proliferation2017

    • Author(s)
      H. Miyashita, T. Takahashi, T. Uchida
    • Organizer
      日本頭頚部癌学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] in1 Functions during early cleavage in mouse embryo2017

    • Author(s)
      Hoshino Y, Miyamoto T, Kawai T, Uchida T, Shimada M
    • Organizer
      World Congress of Reproductive Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Par14の細胞周期進行制御機能の解明2017

    • Author(s)
      竹原一真、内田隆史
    • Organizer
      生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Pin1による tauを介した巨核球胞体形成制御機構2017

    • Author(s)
      清水泰希、菅原佑衣、広瀬恵子、清水律子、本橋ほづみ、内田千代子、内田隆史
    • Organizer
      生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Pin1阻害作用のある褐藻類ポリフェノールは PPARγ レベルを低下させることでマウスの肥満を抑制した2017

    • Author(s)
      岡田拓実、鈴木充子、生地紘子、内田隆史
    • Organizer
      日本農芸化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] MRIによるPin1遺伝子欠損マウスの脳の容量の解析2017

    • Author(s)
      発表者;大滝博和、渡邊 潤、矢倉一道、宮本和幸、土肥謙二、内田隆史、本田一穂
    • Organizer
      第122回日本解剖学会総会
    • Related Report
      2016 Annual Research Report
  • [Presentation] プロリン異性化酵素Pin1 阻害ポリフェノールの発見2016

    • Author(s)
      對馬 早織、日高 將文、高橋 典子、津吹 政可、内田 隆史
    • Organizer
      日本農芸化学会2016年大会
    • Place of Presentation
      札幌コンベンションセンター(北海道、札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Crisper/Cas9 法によるPin1-欠損ヒト細胞の作製と解析2016

    • Author(s)
      秋吉 皓太、イ タツチュウ;、カスジャン マシュー、内田 隆史
    • Organizer
      日本農芸化学会2016年大会
    • Place of Presentation
      札幌コンベンションセンター(北海道、札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] プロリン異性化酵素Pin1は受精卵の卵割に機能する2016

    • Author(s)
      星野由美、宮本拓真、川合智子、内田隆史、島田昌之
    • Organizer
      第38回日本分子生物学会年会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Growth arrest specific protein 7bによる微小管関連蛋白質Tauの制御2016

    • Author(s)
      清水泰希、藤田彩子、後藤愛那、日高將文、内田隆史
    • Organizer
      第89回日本生化学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] プロリン異性化酵素Pin1阻害剤である褐藻ポリフェノールによる脂肪由来間葉系幹細胞の脂肪細胞への分化抑制2016

    • Author(s)
      鈴木充子、佐伯俊之、内田隆史、内田千代子
    • Organizer
      第89回日本生化学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] c-Mycとの相互作用によるPin1の構造変化を解析できるFRET法の確立2016

    • Author(s)
      畠山皓大, 岡部恵美子、日高将文、内田隆史
    • Organizer
      第89回日本生化学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Pin1はCamKIIの活性を低下させることでTauの機能制御を行う2016

    • Author(s)
      菅原佑衣、金井研太、清水泰希、広瀬恵子、日高将文、内田千代子、内田隆史
    • Organizer
      第89回日本生化学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] プロリン異性化酵素Pin1による着床前初期胚発生に果たす役割2016

    • Author(s)
      星野由美、川合智子、内田隆史、島田昌之
    • Organizer
      第34回日本受精着床学会総会・学術講演会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Establishment of mesenchymal stem cell line from p53-deleted mouse and its application to drug discovery2016

    • Author(s)
      Uchida T, Miyashita T, Suzuki T, Suzuki A, Uchida C
    • Organizer
      Bioprocessing summit
    • Related Report
      2016 Annual Research Report
  • [Presentation] 卵子の形成・成熟、受精後の初期胚発生過程におけるプロリン異性化酵素Pin1の発現と機能2016

    • Author(s)
      星野由美、川合智子、内田隆史、島田昌之
    • Organizer
      第57回日本卵子学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Pin1は脂肪由来間葉系幹細胞の分化を促進させた2015

    • Author(s)
      鈴木寿弥、鈴木充子、宮下拓也、佐伯俊幸、阿部素子、内田隆史
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県、神戸市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 海藻ポリフェノールはPin1活性を阻害しマウスの脂肪量を低下させた2015

    • Author(s)
      鈴木充子、宮下拓也、秋吉皓太、鈴木寿弥、日高将文、内田隆史、内田千代子
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県、神戸市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Pin1による巨核球膜構造変化制御2015

    • Author(s)
      清水泰希、鈴木伸幸、本橋ほづみ、内田隆史
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県、神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス卵子および初期胚におけるPin1の局在解析2015

    • Author(s)
      高橋さゆり et al
    • Organizer
      日本卵子学会
    • Place of Presentation
      栃木県総合文化センター(栃木県宇都宮市)
    • Year and Date
      2015-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] プロリン異性化酵素Pin1によるGSK3bおよびCaMKIIの制御2015

    • Author(s)
      馬場貴大 et al
    • Organizer
      日本農芸化学会
    • Place of Presentation
      岡山大学
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Pin1 gene deficient mice impaired spatial cognitive function and exhibited frontotemporal lobar atrophy2015

    • Author(s)
      Ohtake H et al
    • Organizer
      日本解剖学会総会・日本生理学会大会合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-03-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] プロリン異性化酵素Pin1による脳内CaMKIIの活性と安定性制御2014

    • Author(s)
      金井研太 et al
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜パシフィコ(神奈川県横浜市)
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pin1の構造変化を可視化するFRETセンサータンパク質の改良2014

    • Author(s)
      岡部恵美子 et al
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜パシフィコ(神奈川県横浜市)
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pin1阻害剤としてのポリフェノール類の構造・機能解析2014

    • Author(s)
      小坂啓太 et al
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜パシフィコ(神奈川県横浜市)
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pin1/p53ダブルノックアウトマウス由来 脂肪由来間葉系幹細胞株の 樹立と解析2014

    • Author(s)
      佐伯俊幸 et al
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜パシフィコ(神奈川県横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 根粒菌の二成分制御システムを利用したNO3-/NO2-バイオセンサーの開発2014

    • Author(s)
      後藤愛那 et al
    • Organizer
      日本生化学会
    • Place of Presentation
      京都国際会館 (京都府京都市)
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 細胞エネルギーを可視化する2014

    • Author(s)
      今村博臣
    • Organizer
      日本バイオイメージング学会
    • Place of Presentation
      大阪大学(大阪府吹田市)
    • Year and Date
      2014-09-06
    • Related Report
      2014 Annual Research Report
  • [Remarks] 東北大学農学研究科

    • URL

      http://www.agri.tohoku.ac.jp/enzyme/index-j.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東北大学 研究者紹介

    • URL

      http://db.tohoku.ac.jp/whois/detail/ae38cb326f0b96ee1ad91693b96e7dc2.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東北大学 サイエンスカフェ

    • URL

      https://www.youtube.com/watch?v=_J8QxG_zszU

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東北大学農学研究科 分子酵素学研究室

    • URL

      http://www.agri.tohoku.ac.jp/enzyme/index-j.html

    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2023-03-23  

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