Analysis of histamine system through genetically modified mice

• Project/Area Number: 26253016
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Tohoku University
• Principal Investigator: Yanai Kazuhiko 東北大学, 医学系研究科, 教授 (50192787)
• Co-Investigator(Kenkyū-buntansha): 吉川 雄朗 東北大学, 医学系研究科, 准教授 (70506633) ; 中村 正帆 東北大学, 医学(系)研究科(研究院), 助教 (80734318) ; 渋谷 勝彦 東北大学, 医学(系)研究科(研究院), 産学官連携研究員 (30596268)
• Project Period (FY): 2014-06-27 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥40,170,000 (Direct Cost: ¥30,900,000、Indirect Cost: ¥9,270,000); Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000); Fiscal Year 2015: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000); Fiscal Year 2014: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
• Keywords: ヒスタミン / ヒスタミン代謝酵素 / ヒスタミントランスポーター

Outline of Final Research Achievements

We investigated the role of brain histamine. We examined the importance of histamine N-methyltransfease (HNMT) for brain functions. Our results showed the essential role of HNMT in the regulation of brain histamine concentration. The aggression and sleep-wake cycles are also controlled by HNMT. We also investigated the involvement of histamine in glial cell functions. Histamine activated astrocytes through histamine H1 receptors. Histamine H3 receptor antagonists improved depression-like behaviors by the modulation of microglial activity. These results demonstrated the importance of histamine clearance for brain functions and the contribution of histamine to glial activity.

Research Products

• [Journal Article] Correlations of (18)F-THK5351 PET with Postmortem Burden of Tau and Astrogliosis in Alzheimer Disease. (2018)
  • Author(s): Harada R, Furukawa K, et al.
  • Journal Title: J Nucl Med Volume: 59 Issue: 4 Pages: 671-674
  • DOI: 10.2967/jnumed.117.197426
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Heparan sulfate in pancreatic β-cells contributes to normal glucose homeostasis by regulating insulin secretion. (2018)
  • Author(s): Matsuzawa T, Yoshikawa T, Iida T, Karpati A, Kitano H, Harada R, Nakamura T, Sugawara A, Yamaguchi Y, Yanai K.
  • Journal Title: Biochem Biophys Res Commun Volume: - Issue: 3 Pages: 688-695
  • DOI: 10.1016/j.bbrc.2018.03.213
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Histamine N-methyltransferase regulates aggression and the sleep-wake cycle (2017)
  • Author(s): Naganuma Fumito、Nakamura Tadaho、Yoshikawa Takeo、Iida Tomomitsu、Miura Yamato、Karpati Aniko、Matsuzawa Takuro、Yanai Atushi、Mogi Asuka、Mochizuki Takatoshi、Okamura Nobuyuki、Yanai Kazuhiko
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 15899-15899
  • DOI: 10.1038/s41598-017-16019-8
  • Peer Reviewed / Open Access
• [Journal Article] Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice (2017)
  • Author(s): Inoue Shin-Ichi、Takahara Shingo、Yoshikawa Takeo、Niihori Tetsuya、Yanai Kazuhiko、Matsubara Yoichi、Aoki Yoko
  • Journal Title: Hum Mol Genet Volume: 26 Issue: 23 Pages: 4715-4727
  • DOI: 10.1093/hmg/ddx354
  • Peer Reviewed
• [Journal Article] JNJ10181457, a histamine H3 receptor inverse agonist, regulates in vivo microglial functions and improves depression-like behaviours in mice (2017)
  • Author(s): Iida Tomomitsu、Yoshikawa Takeo、Karpati Aniko、Matsuzawa Takuro、Kitano Haruna、Mogi Asuka、Harada Ryuichi、Naganuma Fumito、Nakamura Tadaho、Yanai Kazuhiko
  • Journal Title: Biochem Biophys Res Commun Volume: 488 Issue: 3 Pages: 534-540
  • DOI: 10.1016/j.bbrc.2017.05.081
  • Peer Reviewed
• [Journal Article] The clinical pharmacology of non-sedating antihistamines. (2017)
  • Author(s): Yanai K, Yoshikawa T, Yanai A, Nakamura T, Iida T, Leurs R, Tashiro M.
  • Journal Title: Pharmacol Ther. Volume: 178 Pages: 148-156
  • DOI: 10.1016/j.pharmthera.2017.04.004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Induced histamine regulates Ni elution from an implanted Ni wire in mice by downregulating neutrophil migration. (2017)
  • Author(s): Kishimoto Y, Asakawa S, Sato T, Takano T, Nakajyo T, Mizuno N, Segawa R, Yoshikawa T, Hiratsuka M, Yanai K, Ohtsu H, Hirasawa N.
  • Journal Title: Exp Dermatol Volume: 印刷中 Issue: 10 Pages: 868-874
  • DOI: 10.1111/exd.13315
  • Peer Reviewed
• [Journal Article] Histamine clearance through polyspecific monoamine transporters in the brain (2017)
  • Author(s): Yoshikawa T and Yanaik
  • Journal Title: Handb Exp Pharmacol Volume: 印刷中 Pages: 173-187
  • DOI: 10.1007/164_2016_13
  • ISBN: 9783319581927, 9783319581941
  • Peer Reviewed
• [Journal Article] Characterization of murine polyspecific monoamine transporters. (2017)
  • Author(s): Miura Y, Yoshikawa T, Naganuma F, Nakamura T, Iida T, Karpati A, Matsuzawa T, Mogi A, Harada R, Yanai K.
  • Journal Title: FEBS Open Bio Volume: 9 Issue: 2 Pages: 237-248
  • DOI: 10.1002/2211-5463.12183
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Synthesis and characterization of 18F-interleukin-8 using a cell-free translation system and 18F-fluoro-L-proline, Journal of Nuclear Medicine (2016)
  • Author(s): Ryuichi Harada, Shozo Furumoto, Takeo Yoshikawa, Yoichi Ishikawa, Katsutoshi Shibuya, Nobuyuki Okamura, Kiichi Ishiwata, Ren Iwata, Kazuhiko Yanai
  • Journal Title: Journal of Nuclear Medicine Volume: 57(4) Issue: 4 Pages: 634-639
  • DOI: 10.2967/jnumed.115.162602
  • Peer Reviewed
• [Journal Article] 18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease (2016)
  • Author(s): Harada R, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Tago T, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y
  • Journal Title: J Nucl Med Volume: 57 Issue: 2 Pages: 208-214
  • DOI: 10.2967/jnumed.115.164848
  • Peer Reviewed
• [Journal Article] Performance evaluation of the small-animal PET scanner ClairvivoPET using NEMA NU 4-2008 Standards. (2016)
  • Author(s): Sato K, Shidahara M, Watabe H, Watanuki S, Ishikawa Y, Arakawa Y, Nai YH, Furumoto S, Tashiro M, Shoji T, Yanai K, Gonda K.
  • Journal Title: Phys Med Biol Volume: 61 Issue: 2 Pages: 696-711
  • DOI: 10.1088/0031-9155/61/2/696
  • Peer Reviewed
• [Journal Article] Histamine H receptor occupancy by the new-generation antipsychotics olanzapine and quetiapine: a positron emission tomography study in healthy volunteers (2015)
  • Author(s): Sato, Hirotoshi Ito, Chihiro Hiraoka, Kotaro Tashiro, Manabu Shibuya, Katsuhiko Funaki, Yoshihito Yoshikawa, Takeo Iwata, Ren Matsuoka, Hiroo Yanai, Kazuhiko
  • Journal Title: Psychopharmacology (Berl) Volume: 232 Issue: 19 Pages: 3497-3505
  • DOI: 10.1007/s00213-015-4002-2
  • Peer Reviewed
• [Journal Article] Histamine H3 receptor in primary mouse microglia inhibits chemotaxis, phagocytosis, and cytokine secretion. (2015)
  • Author(s): Iida T, Yoshikawa T, Matsuzawa T, Naganuma F, Nakamura T, Miura Y, Mohsen AS, Harada R, Iwata R, Yanai K.
  • Journal Title: Glia Volume: - Issue: 7 Pages: 1213-1225
  • DOI: 10.1002/glia.22812
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Amyloid deposits and response to shunt surgery in idiopathic normal-pressure hydrocephalus (2015)
  • Author(s): Hiraoka, Kotaro Narita, Wataru Kikuchi, Hirokazu Baba, Toru Kanno, Shigenori Iizuka, Osamu Tashiro, Manabu Furumoto, Shozo Okamura, Nobuyuki Furukawa, Katsutoshi Arai, Hiroyuki Iwata, Ren Mori, Etsuro Yanai, Kazuhiko
  • Journal Title: J Neurol Sci Volume: 356 Issue: 1-2 Pages: 124-128
  • DOI: 10.1016/j.jns.2015.06.029
  • Peer Reviewed
• [Journal Article] Quantitative kinetic analysis of PET amyloid imaging agents [(11)C]BF227 and [(18)F]FACT in human brain. (2015)
  • Author(s): Shidahara M, Watabe H, Tashiro M, Okamura N, Furumoto S, Watanuki S, Furukawa K, Arakawa Y, Funaki Y, Iwata R, Gonda K, Kudo Y, Arai H, Ishiwata K, Yanai K.
  • Journal Title: Nucl Med Biol. Volume: 42 Issue: 9 Pages: 734-744
  • DOI: 10.1016/j.nucmedbio.2015.05.001
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] [18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease (2015)
  • Author(s): Harada R, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T, Tago T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y.
  • Journal Title: Eur J Nucl Med Mol Imaging. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Role of Histamine H3 Receptor in Glucagon-Secreting αTC1.6 cells (2015)
  • Author(s): Tadaho Nakamura, Takeo Yoshikawa, Fumito Naganuma, Attyeb Mohsen, Tomomitsu iida, Yamato Miura, Akira Sugawara and Kazuhiko Yanai
  • Journal Title: FEBS Open Bio Volume: 5 Issue: 1 Pages: 36-41
  • DOI: 10.1016/j.fob.2014.12.001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Brain histamine H1 receptor occupancy measured by PET after oral administration of levocetirizine, a non-sedating antihistamine. (2015)
  • Author(s): Hiraoka K, Tashiro M, Grobosch T, Maurer M, Oda K, Toyohara J, Ishii K, Ishiwata K, Yanai K.
  • Journal Title: Expert Opin Drug Saf. Volume: 14 Issue: 2 Pages: 199-206
  • DOI: 10.1517/14740338.2015.989831
  • Peer Reviewed / Open Access
• [Journal Article] Structural abnormality of the hippocampus associated with depressive symptoms in heart failure rats. (2015)
  • Author(s): Suzuki H, Sumiyoshi A, Matsumoto Y, Duffy BA, Yoshikawa T, Lythgoe MF, Yanai K, Taki Y, Kawashima R, Shimokawa H.
  • Journal Title: Neuroimage. Volume: 105 Pages: 84-92
  • DOI: 10.1016/j.neuroimage.2014.10.040
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Insufficient intake of L-Histidine reduces brain histamine and causes anxiety-like behaviors in male mice. (2015)
  • Author(s): Takeo Yoshikawa, Tadaho Nakamura, Testuro Shibakusa, Mayu Sugita, Fumito Naganuma, Tomomitsu Iida, Yamato Miura, Attayeb Mohsen, Ryuichi Harada, and Kazuhiko Yanai
  • Journal Title: The Journal of nutrition Volume: 144 Issue: 10 Pages: 1637-1641
  • DOI: 10.3945/jn.114.196105
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] [18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease. (2014)
  • Author(s): Harada R, Furukawa K, et al.
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 42 Issue: 7 Pages: 1052-1061
  • DOI: 10.1007/s00259-015-3035-4
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Pitfalls of voxel-based amyloid PET analyses for diagnosis of Alzheimer's disease: artifacts due to non-specific uptake in the white matter and the skull. (2014)
  • Author(s): Arai A, Kaneta T, Okamura N, Tashiro M, Iwata R, Takanami K, Fukuda H, Takahashi S, Yanai K, Kudo Y, Arai H.
  • Journal Title: Tohoku J Exp Med Volume: 234 Pages: 175-181
  • NAID: 130004694506
  • Peer Reviewed / Open Access
• [Journal Article] Tau PET imaging in Alzheimer’s disease (2014)
  • Author(s): Nobuyuki Okamura, Ryuichi Harada, Shozo Furumoto, Hiroyuki Arai, Kazuhiko Yanai, Yukistsuka Kudo,
  • Journal Title: Current Neurology and Neuroscience Reports Volume: 14 Issue: 11 Pages: 500-500
  • DOI: 10.1007/s11910-014-0500-6
  • Peer Reviewed / Open Access
• [Journal Article] Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using ^<18>F-THK5105 PET (2014)
  • Author(s): Nobuyuki Okamura, Shozo Furumoto, Michelle T. Fodero-Tavoletti, Rachel S. Mulligan, Ryuichi Harada, Paul Yates, Svetlana Pejoska, Yukitsuka Kudo, Colin L. Masters, Kazuhiko Yanai, Christopher C. Rowe, Victor L. Villemagne
  • Journal Title: Brain Volume: 137 Issue: 6 Pages: 1762-1771
  • DOI: 10.1093/brain/awu064
  • Peer Reviewed / Open Access
• [Journal Article] Mechanism of the histamine H3 receptor-mediated increase in exploratory locomotor activity and anxiety-like behaviours in mice (2014)
  • Author(s): Mohsen A, Yoshikawa T, Miura Y, Nakamura T, Naganuma F, Shibuya K, Iida T, Harada R, Okamura N, Watanabe T, Yanai K.
  • Journal Title: Neuropharmacology Volume: 81 Pages: 188-94
  • DOI: 10.1016/j.neuropharm.2014.02.003
  • Peer Reviewed / Open Access
• [Journal Article] In vivo evaluation of a novel tau imaging tracer for Alzheimer's disease (2014)
  • Author(s): Villemagne L. Victor, Shozo Furumoto, Michelle T. Fodero-Tavoletti, Rachel S. Mulligan, John Hodges, Ryuichi Harada, Paul Yates, Oliver Piguet, Svetlana Pejoska, Vincent Doré, Kazuhiko Yanai, Colin L. Masters, Yukitsuka Kudo, Christopher C. Rowe, Nobuyuki Okamura.
  • Journal Title: European Journal of Nuclear Medicine and Molecular Imaging Volume: 41 Issue: 5 Pages: 816-826
  • DOI: 10.1007/s00259-013-2681-7
  • Peer Reviewed / Open Access
• [Journal Article] Predominant role of plasma membrane monoamine transporters in monoamine transport in 1321N1 cells, a human astrocytoma-derived cell line. (2014)
  • Author(s): Fumito Naganuma, Takeo Yoshikawa, Tadaho Nakamura, Tomomistu Iida, Ryuichi Harada, Attayeb S. Mohsen, Yamato Miura and Kazuhiko Yanai.
  • Journal Title: Journal of Neurochemistry Volume: 129 Issue: 4 Pages: 591-601
  • DOI: 10.1111/jnc.12665
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Analysis of early phase [^(11)C]BF-227 PET , and its application for anatomical standardization of late-phase images for 3D-SSP analysis (2014)
  • Author(s): Kaneta T, Okamura N, Arai A, Takanami K, Furukawa K, Tashiro M, Furumoto S, Iwata R, Takahashi S, Arai H, Y anai K, Kudo Y
  • Journal Title: Jpn J Radiol Volume: 32 Issue: 3 Pages: 138-144
  • DOI: 10.1007/s11604-013-0276-7
  • NAID: 50009030775
  • Peer Reviewed / Open Access
• [Journal Article] Imaging of amyloid deposition in human brain using positron emission tomography and [18F]FACT: comparison with [11C]PIB. (2014)
  • Author(s): Ito H, Shinotoh H, Shimada H, Miyoshi M, Yanai K, Okamura N, Takano H, Takahashi H, Arakawa R, Kodaka F, Ono M, Eguchi Y, Higuchi M, Fukumura T, Suhara T.
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 41 Pages: 745-754
  • Peer Reviewed / Open Access
• [Presentation] 新規遺伝子ノックアウトマウスを用いた脳内ヒスタミンクリアランス系の解明 (2017)
  • Author(s): 吉川雄朗、谷内一彦
  • Organizer: 第90回日本薬理学会年会
  • Place of Presentation: 長崎（ブリックホール）
  • Year and Date: 2017-03-15
• [Presentation] 神経障害性疼痛に対するヒスタミンH3受容体拮抗薬の効果 (2017)
  • Author(s): 吉川雄朗、松澤拓郎、茂木明日香、Maria Mogilevskaya、中村正帆、谷内一彦
  • Organizer: 第90回日本薬理学会年会
  • Place of Presentation: 長崎（ブリックホール）
  • Year and Date: 2017-03-15
• [Presentation] ヒスタミン3型受容体インバースアゴニストはミクログリア機能を抑制しうつ様行動を改善する (2017)
  • Author(s): 飯田智光、吉川雄朗、谷内一彦
  • Organizer: 第21回日本ヒスタミン学会
• [Presentation] 脳内ヒスタミン神経系の過剰な興奮はH2受容体を介してマウスの攻撃性を増加させる (2017)
  • Author(s): 吉川雄朗、飯田智光、長沼史登、中村正帆、岡村信行、谷内一彦
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
• [Presentation] 骨格筋におけるヘパラン硫酸の役割について (2017)
  • Author(s): 吉川雄朗、茂木明日香、松澤拓郎、三浦大和、中村正帆、谷内一彦
  • Organizer: 第68回日本薬理学会北部会
• [Presentation] THE EFFECT OF H3 RECEPTOR ANTAGONIST ON NEUROPATHIC PAIN (2017)
  • Author(s): T Nakamura, T Matsuzawa, M Mogilevskaya, A Mogi, T Yoshikawa, F Naganuma, N Okamura, K Yanai
  • Organizer: Histamine 2017
  • Int'l Joint Research
• [Presentation] Role of histamine neurons in isoflurane anesthesia. (2016)
  • Author(s): Tadaho Nakamura, Takeo Yoshikawa, Fumito Naganuma, Tomomitsu Iida, Aniko Karpati, Toru Tamii, Nobuyuki Okamura, Kazuiko Yanai
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜（パシフィコ横浜）
  • Year and Date: 2016-07-20
• [Presentation] Importance of histamine N-methyltransferase in brain functions (2016)
  • Author(s): Takeo Yoshikawa, Fumito Naganuma, Tadaho Nakamura, Takatoshi Mochizuki, Tomomitsu Iida, Aniko Karpati, Takuro Matsuzawa, Kazuhiko Yanai
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜（パシフィコ横浜）
  • Year and Date: 2016-07-20
• [Presentation] Histamine N-methyltransferase is important for the normal sleep-wake cycles and aggression through the regulation of brain histamine concentration. (2016)
  • Author(s): Fumito Naganuma, Takeo Yoshikawa, Tadaho Nakamura, Kazuhiko Yanai
  • Organizer: 30th CINP world congress of neuropsychopharmacology
  • Place of Presentation: 韓国 ソウル
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] Electroencephalogram of H1KO mice under isoflurane anesthesia. (2016)
  • Author(s): Tadaho, Nakamura, Takeo Yoshikawa, Fumito Naganuma, Tomomitsu Iida, Aniko Karpati, Toru Tamii, Nobuyuki Okamura, Kazuiko Yanai
  • Organizer: European Histamine Research Society 45th annual meeting
  • Place of Presentation: イタリア フィレンツェ
  • Year and Date: 2016-05-11
  • Int'l Joint Research
• [Presentation] Role of brain histamine in glutamate release from cultured astrocytes (2016)
  • Author(s): Aniko Karpati、吉川雄朗、中村正帆、長沼史登、飯田智光、三浦大和、谷内一彦
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: 横浜（パシフィコ横浜）
  • Year and Date: 2016-03-09
• [Presentation] マウスにおけるヒスタミン神経系とイソフルラン麻酔の相互作用について (2016)
  • Author(s): 中村正帆、吉川雄朗、長沼史登、飯田智光、三浦大和、Aniko Karpati、望月貴年、谷内一彦
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: 横浜（パシフィコ横浜）
  • Year and Date: 2016-03-09
• [Presentation] Histamine N-methyltransferaseの欠損はマウスにおいて睡眠覚醒サイクル異常と高い攻撃性を引き起こす (2016)
  • Author(s): 長沼史登、吉川雄朗、中村正帆、堀米愛、三浦大和、矢内敦、望月貴年、谷内一彦
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: 横浜（パシフィコ横浜）
  • Year and Date: 2016-03-09
• [Presentation] 膵β細胞におけるヘパラン硫酸の重要性 (2016)
  • Author(s): 松澤拓郎、吉川雄朗、中村正帆、谷内一彦
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: 横浜（パシフィコ横浜）
  • Year and Date: 2016-03-09
• [Presentation] Role of histaminergic neuronal system in isoflurane anesthesia (2015)
  • Author(s): Tadaho Nakamura, Takeo Yoshikawa, Fumito Naganuma, Osamu Kobayashi, Miho Kaneko, Masanori Yamauchi, Kazuhiko Yanai
  • Organizer: Anesthesiology 2015
  • Place of Presentation: アメリカ、サンディエゴ
  • Year and Date: 2015-10-24
  • Int'l Joint Research
• [Presentation] Histamine N-methyltransferseノ欠損はマウスにおいて攻撃性を高め、睡眠サイクル異常を引き起こす (2015)
  • Author(s): 長沼史登、吉川雄朗、堀米愛、三浦大和、中村正帆、矢内敦、望月貴年、谷内一彦
  • Organizer: 第37回日本生物学的精神医学会第45回日本精神神経薬理学会
  • Place of Presentation: 東京（タワーホール船橋）
  • Year and Date: 2015-09-24
• [Presentation] 生体内ミクログリアにおける中枢ヒスタミン系の役割 (2015)
  • Author(s): 飯田智光、吉川雄朗、松澤拓郎、長沼史登、中村正帆、三浦大和、谷内一彦
  • Organizer: 第66回日本薬理学会北部会
  • Place of Presentation: 富山（富山国際会議場）
  • Year and Date: 2015-09-18
• [Presentation] イソフルランの麻酔作用におけるヒスタミン神経系の役割 (2015)
  • Author(s): 中村正帆、吉川雄朗、長沼史登、三浦大和、飯田智光、松澤拓郎、堀米愛、Karpati Aniko、谷内一彦
  • Organizer: 第66回日本薬理学会北部会
  • Place of Presentation: 富山（富山国際会議場）
  • Year and Date: 2015-09-18
• [Presentation] Histamine N-methyltransferase deficiency induced the abnormal sleep-awake cycles and aggressive behavior in mice (2015)
  • Author(s): 長沼史登、吉川雄朗、矢内敦、堀米愛、三浦大和、中村正帆、望月貴年、谷内一彦
  • Organizer: 第58回日本神経化学大会
  • Place of Presentation: 大宮（大宮ソニックシティ）
  • Year and Date: 2015-09-11
• [Presentation] ヒスタミン研究に残された解決されるべき課題：脳内ヒスタミンの分解系を中心に (2015)
  • Author(s): 谷内一彦、長沼史登、中村正帆、岡村信行、吉川雄朗
  • Organizer: 第19回活性アミンに関するワークショップ
  • Place of Presentation: いわき（小名浜オーシャンホテル）
  • Year and Date: 2015-08-20
  • Invited
• [Presentation] マウス多基質性トランスポーターによるモノアミン輸送能の検討 (2015)
  • Author(s): 三浦大和、吉川雄朗、長沼史登、中村正帆、飯田智光、谷内一彦
  • Organizer: 第19回活性アミンに関するワークショップ
  • Place of Presentation: いわき（小名浜オーシャンホテル）
  • Year and Date: 2015-08-20
• [Presentation] Mechanism of brain histamine clearance (2015)
  • Author(s): 吉川雄朗、長沼史登、三浦大和、矢内敦、堀米愛、中村正帆、望月貴年、谷内一彦
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸（神戸国際会議場）
  • Year and Date: 2015-07-28
• [Presentation] Role of histamine in gliotransmitter release from astrocytes (2015)
  • Author(s): Aniko Karpati, Takeo Yoshikawa, Tadaho Nakamura, Fumito Naganuma, Tomomitsu Iida, Yamato Miura, Kazuhiko Yanai
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸（神戸国際会議場）
  • Year and Date: 2015-07-28
• [Presentation] Analysis of histamine N-methyltransferase deficient mice (2015)
  • Author(s): Naganuma F, Yoshikawa T, Nakamura T, Miura Y, Matsuzawa T, Yanai K
  • Organizer: European Histamine Research Society 44th annual meeting
  • Place of Presentation: スペイン（マラガ）
  • Year and Date: 2015-05-06
  • Int'l Joint Research
• [Presentation] H1-knocked out mouse had high sensitivity to isoflurane anesthesia (2015)
  • Author(s): Nakamura T, Yoshikawa T, Naganuma F, iida T, Miura Y, Yanai K
  • Organizer: European Histamine Research Society 44th annual meeting
  • Place of Presentation: スペイン（マラガ）
  • Year and Date: 2015-05-06
  • Int'l Joint Research
• [Presentation] Histamine N-methyltransferase ノックアウトマウスの解析 (2015)
  • Author(s): 長沼史登、吉川雄朗、三浦大和、柳生彩乃、中村正帆、谷内一彦
  • Organizer: 第88回日本薬理学年会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-03-18 – 2015-03-20
• [Presentation] イソフルラン麻酔における神経ヒスタミンとヒスタミンH1受容体の役割 (2015)
  • Author(s): 中村正帆、吉川雄朗、長沼史登、飯田智光、三浦大和、谷内一彦
  • Organizer: 第88回日本薬理学年会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-03-18 – 2015-03-20
• [Presentation] 骨格筋特異的Ext1欠損マウスの解析 (2015)
  • Author(s): 三浦大和、吉川雄朗、中村正帆、長沼史登、飯田智光、谷内一彦
  • Organizer: 第88回日本薬理学年会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-03-18 – 2015-03-20
• [Presentation] タウPETプローブ[18F]THK-5351の開発と臨床評価 (2015)
  • Author(s): 谷内一彦、岡村信行、原田龍一、古本祥三、多胡哲郎、古川勝敏、岩田錬、田代学、荒井啓行、工藤幸司
  • Organizer: 第88回日本薬理学年会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-03-18 – 2015-03-20
• [Presentation] Histamine N-methyltransferaseノックアウトマウスの行動解析 (2015)
  • Author(s): 長沼史登、吉川雄朗、中村正帆、三浦大和、堀米愛、谷内一彦
  • Organizer: 第24回神経行動薬理若手研究者の集い
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-03-17
• [Presentation] 脳内ヒスタミン研究におけるマイクロダイアリシスの使用について (2014)
  • Author(s): 吉川雄朗、中村正帆、長沼史登、三浦大和、谷内一彦
  • Organizer: 第２５回マイクロダイアリシス研究会
  • Place of Presentation: お茶の水女子大学（東京都文京区）
  • Year and Date: 2014-12-20
  • Invited
• [Presentation] マウスにおける低親和性トランスポーターの輸送能解析 (2014)
  • Author(s): 三浦大和、吉川雄朗、長沼史登、中村正帆、谷内一彦
  • Organizer: 第18回日本ヒスタミン学会
  • Place of Presentation: ホテルニューアルカイック（兵庫県尼崎市）
  • Year and Date: 2014-10-10 – 2014-10-11
• [Presentation] Histamine N-methyl transferaseノックアウトマウスの解析 (2014)
  • Author(s): 長沼史登、吉川雄朗、三浦大和、中村正帆、谷内一彦
  • Organizer: 第18回日本ヒスタミン学会
  • Place of Presentation: ホテルニューアルカイック（兵庫県尼崎市）
  • Year and Date: 2014-10-10 – 2014-10-11
• [Presentation] 低ヒスチジン食によりマウス脳内ヒスタミン含量が減少し、不安様行動が惹起される (2014)
  • Author(s): 吉川雄朗、中村正帆、柴草哲朗、杉田麻友、長沼史登、飯田智光、三浦大和、モフセンアタイエブ、原田龍一、谷内一彦
  • Organizer: 第18回日本ヒスタミン学会
  • Place of Presentation: ホテルニューアルカイック（兵庫県尼崎市）
  • Year and Date: 2014-10-10 – 2014-10-11
• [Presentation] 無細胞蛋白質合成法を用いたPETイメージングプローブ作製 (2014)
  • Author(s): 吉川雄朗、原田龍一、古本祥三、渋谷勝彦、岩田錬、谷内一彦
  • Organizer: 第65回日本薬理学会北部会
  • Place of Presentation: コラッセ福島（福島県福島市）
  • Year and Date: 2014-09-26 – 2014-09-27
• [Presentation] ヒスタミン代謝酵素欠損マウスの解析 (2014)
  • Author(s): 吉川雄朗、長沼史登、三浦大和、柳生彩乃、谷内一彦
  • Organizer: 第65回日本薬理学会北部会
  • Place of Presentation: コラッセ福島（福島県福島市）
  • Year and Date: 2014-09-26 – 2014-09-27
• [Presentation] Expression and Function of Histamine H3 receptor in Pancreatic Islets (2014)
  • Author(s): Tadaho Nakamura, Takeo Yoshikawa, Kazuhiko Yanai
  • Organizer: 17th world congress of basic & clinical pharmacology
  • Place of Presentation: ケープタウン（南アフリカ）
  • Year and Date: 2014-07-13 – 2014-07-18
• [Presentation] The mechanism of monoamine transport by human astrocytes (2014)
  • Author(s): Fumito Naganuma, Takeo Yoshikawa, Tadaho Nakamura, Tomomitsu Iida, Yamato Miura, Kazuhiko Yanai
  • Organizer: 17th world congress of basic & clinical pharmacology
  • Place of Presentation: ケープタウン（南アフリカ）
  • Year and Date: 2014-07-13 – 2014-07-18