Cellular interaction in liver inflammation and regeneration
| Project/Area Number |
26253023
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Minoru 国立国際医療研究センター, 室長 (80321909)
ITOH Tohru 東京大学, 分子細胞生物学研究所, 准教授 (50396917)
ENOMOTO Yutaka 東京大学, 分子細胞生物学研究所, 助教 (20608210)
KIDO Taketomo 東京大学, 分子細胞生物学研究所, 助教 (00401034)
SAIJOU Eiko 東京大学, 分子細胞生物学研究所, 技術専門員 (60376647)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥40,820,000 (Direct Cost: ¥31,400,000、Indirect Cost: ¥9,420,000)
Fiscal Year 2016: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2015: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2014: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
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| Keywords | 炎症 / 再生 / 線維化 / サイトカイン / イメージング / 肝炎 / 胆管 / 肝臓 / 肝障害 / 肝細胞 / 間葉系細胞 / 幹細胞 / 免疫 |
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| Outline of Final Research Achievements |
This study was aimed at elucidating the cellular basis of liver inflammation and regeneration. Ductular reaction in chronic liver injuries is characterized by amplification of duct like cells. We developed novel methods for imaging and cell fact tracking to reveal the mode of remodeling of bile ducts. Proliferating duct cells were found to be localized at the periphery of the ducts and their fate was stochastically determined. We found that expression of Oncostatin M in the liver induces fibrosis without inflammation and using this system we revealed cellular interactions among liver cells, which lead to fibrosis. Over expression of IL-4 in the liver induces a distinct class of NK cells that possess strong cytotoxic activity against tumor cells.
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Report
(4 results)
Research Products
(50 results)
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[Presentation] 肝臓の炎症と再生2015
Author(s)
宮島篤
Organizer
第３６回日本炎症・再生医学会
Place of Presentation
虎ノ門ヒルズフォーラム（ 東京都港区）
Year and Date
2015-07-21
Related Report
Invited
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[Presentation] 肝再生のメカニズム2015
Author(s)
宮島篤
Organizer
第８０回日本インターフェロン・サイトカイン学会
Place of Presentation
東京工業大学蔵前会館(東京都目黒区）
Year and Date
2015-07-21
Related Report
Invited
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