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Formation factors of physiological activity and ecological impact level among east Asia and England

Research Project

Project/Area Number 26257302
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Risk sciences of radiation and chemicals
Research InstitutionKyoto University

Principal Investigator

Hiroaki Tanaka  京都大学, 工学研究科, 教授 (70344017)

Co-Investigator(Kenkyū-buntansha) 中田 典秀  京都大学, 工学研究科, 助教 (00391615)
宮川 信一  大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), その他部局等, 助教 (30404354)
井原 賢  京都大学, 工学研究科, 特定助教 (70450202)
井口 泰泉  横浜市立大学, 生命ナノシステム科学研究科(八景キャンパス), 特任教授 (90128588)
山下 尚之  京都大学, 工学研究科, 講師 (90391614)
李 善太  京都大学, 工学研究科, 特定研究員 (60771962)
花本 征也  京都大学, 工学(系)研究科(研究院), 研究員 (10727580)
Co-Investigator(Renkei-kenkyūsha) HANAMOTO Seiya  土木研究所, 水環境研究グループ, 研究員 (10727580)
Research Collaborator JOHNSON Andrew  英国生態水文研究所, 教授
PARK Chulhwi  ソウル市立大学校, 環境工学, 教授
WU Guangxue  清華大学, 深圳研究生院, 准教授
PARK Junwon  韓国環境科学院, 研究員
ZHANG Han  京都大学, 大学院工学研究科, 特定研究員
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥40,690,000 (Direct Cost: ¥31,300,000、Indirect Cost: ¥9,390,000)
Fiscal Year 2016: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2015: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2014: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Keywords生理活性 / 医薬品類 / 下水 / 河川 / レポータージーンアッセイ / Gタンパク結合受容体(GPCR) / アルカリホスファターゼ融合TGFα切断アッセイ / 抗うつ剤受容体アッセイ / 化学分析 / 下水処理 / 膜分離活性汚泥法 / モデル / バイオアッセイ / エストロゲン様作用 / TGFα切断アッセイ / 生理作用 / モデル化 / 薬理作用 / 機器分析
Outline of Final Research Achievements

This research focuses on physiological activities caused by estrogens and pharmaceuticals and personal care products(PPCPs), etc. Field investigation at rivers and sewage treatment plants were performed in Japan, England, Korea and China in order to know physiological activity of sewage in their river basins. We applied reporter gene assays using fish hormone receptor, G-protein combined receptor (GPCR) Transforming growth factor-α(TGFα)shedding assay and depressant transporter uptake inhibition assay to environmental samples in addition to chemical analyses for evaluatation of endocrine disrupting and physiological activities. We compared contamination levels among east Asia and England from the viewpoint of physiological activities. Then, we studied and compared the fate of PPCPs in water environment and sewage treatment among them.

Report

(4 results)
  • 2017 Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (72 results)

All 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (3 results) Journal Article (19 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 16 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (49 results) (of which Int'l Joint Research: 18 results,  Invited: 9 results) Book (1 results)

  • [Int'l Joint Research] 水文生態研究所/Brunel大学/Exter大学(英国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] 清華大学/深セン水務集団(中国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] ソウル市立大学校/韓国建設技術院(韓国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Source estimation of pharmaceuticals based on catchment population and in-stream attenuation in Yodo River watershed, Japan2018

    • Author(s)
      Hanamoto, S., Nakada, N., Yamashita, N., Tanaka, H.
    • Journal Title

      Science of the Total Environment

      Volume: 615 Pages: 964-971

    • DOI

      10.1016/j.scitotenv.2017.10.013

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The different fate of antibiotics in the Thames River, UK, and the Katsura River, Japan2018

    • Author(s)
      Hanamoto, S., Nakada, N., Johnson, AC., Jürgens, MD., Yamashita, N., Tanaka, H.
    • Journal Title

      Environmental Science and Pollution Research

      Volume: 25 Issue: 2 Pages: 1903-1913

    • DOI

      10.1007/s11356-017-0523-z

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 下水,河川水からの医薬品生理活性の検出2018

    • Author(s)
      井原賢, 張 晗, 花本征也,田中宏明
    • Journal Title

      薬学雑誌

      Volume: 38 Pages: 281-287

    • NAID

      130006410647

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane fouling control and enhanced removal of pharmaceuticals and personal care products by coagulation-MBR2018

    • Author(s)
      J. Park, N.Yamashita, H.Tanaka
    • Journal Title

      Chemosphere

      Volume: 197 Pages: 467-476

    • DOI

      10.1016/j.chemosphere.2018.01.063

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessing the population equivalent and performance of wastewater treatment through the ratios of pharmaceuticals and personal care products present in a river basin: Application to the River Thames basin, UK2017

    • Author(s)
      Nakada, N., Hanamoto, S., Jurgens, MD., Johnson, AC., Bowes, MJ., Tanaka, H.
    • Journal Title

      Science of the Total Environment

      Volume: 575 Pages: 1100-1108

    • DOI

      10.1016/j.scitotenv.2016.09.180

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Linking changes in antibiotic effluent concentrations to flow, removal and consumption in four different UK sewage treatment plants over four years2017

    • Author(s)
      161.Johnson, AC., Jurgens, MD., Nakada, N., Hanamoto, S., Singer, AC., Tanaka, H.
    • Journal Title

      Environmental Pollution

      Volume: 220 Pages: 919-926

    • DOI

      10.1016/j.envpol.2016.10.077

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Removal characteristics of pharmaceuticals and personal care products: Comparison between membrane bioreactor and various biological treatment processes2017

    • Author(s)
      Park, J., Yamashita, N., Park, C., Shimono, T., Takeuchi, D., Tanaka, H.
    • Journal Title

      Chemosphere

      Volume: 179 Pages: 371-380

    • DOI

      10.1016/j.chemosphere.2017.03.135

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Removal of pharmaceuticals and personal care products by ammonia oxidizing bacteria acclimated in a membrane bioreactor: Contributions of cometabolism and endogenous respiration2017

    • Author(s)
      Park, J., Yamashita, N., Wu, G., Tanaka, H.
    • Journal Title

      Sci. Total Environ

      Volume: 605-606 Pages: 18-25

    • DOI

      10.1016/j.scitotenv.2017.06.155

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Detection of physiological activities og G protein-coupled receptor-acting pharmaceuticals in wastewater.2015

    • Author(s)
      Masaru Ihara, Asuka Inoue, Seiya Hanamoto, Han Zhang, Jyunken Aoki, Hiroaki Tanaka.
    • Journal Title

      Envrionmental Science and Technology

      Volume: 49 Issue: 3 Pages: 1903-1911

    • DOI

      10.1021/es505349s

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Challenge Presented by Progestins in Ecotoxicological Research: A Critical Review.2015

    • Author(s)
      Vimal Kumar, Andrew C. Johnson, Achim Trubiroha, Jitka Tumova, Masaru Ihara, Roman Grabic, Werner Kloas, Hiroaki Tanaka, Hana Kocour Kroupova.
    • Journal Title

      Envrionmental Science and Technology

      Volume: 49 Issue: 5 Pages: 2625-2638

    • DOI

      10.1021/es5051343

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of Estrogenic Activity of Wastewater: Comparison Among In Vitro ERα Reporter Gene Assay, In Vivo Vitellogenin Induction, and Chemical Analysis2015

    • Author(s)
      Masaru Ihara, Tomokazu Kitamura, Vimal Kumar, Chang-Beom Park, Mariko O. Ihara, Sang-Jung Lee, Naoyuki Yamashita, Shinichi Miyagawa, Taisen Iguchi, Seiichiro Okamoto, Yutaka Suzuki, and Hiroaki Tanaka
    • Journal Title

      Environmental Science and Technology

      Volume: 49 Issue: 10 Pages: 6319-26

    • DOI

      10.1021/acs.est.5b01027

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Understanding the molecular basisi for differences in responses of fish estrogen receptor subtypes to environmental estrogens2015

    • Author(s)
      Tohyama S, Miyagawa S, Lange A, Ogino Y, Mizutani T, Tatarazako N, Katsu Y, Ihara M, Tanaka H, Ishibashi H, Kobayashi T, Tyler CR, Iguchi T
    • Journal Title

      Environ Sci Technol

      Volume: 49 Issue: 12 Pages: 7439-7447

    • DOI

      10.1021/acs.est.5b00704

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influence of Hydraulic Retention Time, Sludge Retention Time, and Ozonation on the Removal of Free and Conjugated Estrogens in Japanese Activated Sludge Treatment Plants2015

    • Author(s)
      Kumar, V., Nakada, N., Yamashita, N., Johnson, A.C., Tanaka, H.
    • Journal Title

      CLEAN-SOIL AIR WATER

      Volume: 49 Issue: 9 Pages: 1289-1294

    • DOI

      10.1002/clen.201400498

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Differing species responsiveness of estrogenic contaminants in fish is conferred by the ligand binding domain of the estrogen receptor2014

    • Author(s)
      Miyagawa, S., Lange, A., Hirakawa, I., Tohyama, S., Ogino, Y., Mizutani, T., Kagami, Y., Kusano, T., Ihara, M., Tanaka, H., Tatarazako, N., Ohta, Y., Katsu, Y., Tyler, C.R. and Iguchi, T.
    • Journal Title

      Environ. Sci. Technol.

      Volume: 未定 Issue: 9 Pages: 5254-5263

    • DOI

      10.1021/es5002659

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Co-occurrence of Estrogenic and Antiestrogenic Activities in Wastewater: Quantitative Evaluation of Balance by in Vitro ERα Reporter Gene Assay and Chemical Analysis2014

    • Author(s)
      "Masaru Ihara, Mariko O. Ihara, Vimal Kumar, Masanori Narumiya, Seiya Hanamoto,Norihide Nakada, Naoyuki Yamashita, Shinichi Miyagawa, Taisen Iguchi, and Hiroaki Tanaka
    • Journal Title

      Envrionmental Science and Technology

      Volume: 48 Issue: 11 Pages: 6366-6373

    • DOI

      10.1021/es5014938

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of the photolysis of pharmaceuticals within a river by 2 year field observations and toxicity changes by sunlight2014

    • Author(s)
      Seiya Hanamoto, Tsukasa Kawakami, Norihide Nakada, Naoyuki Yamashita and Hiroaki Tanaka
    • Journal Title

      Environmental Science: Processes & Impacts

      Volume: 16 Issue: 12 Pages: 2796-2803

    • DOI

      10.1039/c4em00448e

    • NAID

      120005657910

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 医薬品および化粧品など残留医薬品類のオゾン処理の有効性2014

    • Author(s)
      金  一昊、田中宏明
    • Journal Title

      用水と廃水

      Volume: 56(4) Pages: 45-54

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 水環境中における医薬品および化粧品など医薬品類の国際的管理動向2014

    • Author(s)
      金  一昊、田中宏明
    • Journal Title

      用水と廃水

      Volume: 56(6) Pages: 47-58

    • NAID

      40020118335

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 医薬品類の下水処理施設での挙動・除去特性・除去に向けた今後の技術的な課題2014

    • Author(s)
      中田典秀、田中宏明
    • Journal Title

      化学工学

      Volume: 78(12) Pages: 11-14

    • Related Report
      2014 Annual Research Report
  • [Presentation] Detection of physiological activities of pharmaceuticals in river water: Suggestions to prioritization of pharmaceuticals in research involving environmental monitoring and toxicity testing2017

    • Author(s)
      Masaru Ihara, Han Zhang, Seiya Hanamoto, and Hiroaki Tanaka
    • Organizer
      SETAC Europe 26th Annual Meeting
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 下水道を取り巻く最近の話題 ー環境規制と再生水の動向ー2017

    • Author(s)
      田中宏明
    • Organizer
      (株)建設技術研究所 大阪本社 意見交換会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] "The fate of ketoprofen’s photo transformation products in waste water treatment plant"2017

    • Author(s)
      E. Hasegawa, S. Hanamoto, N. Nakada, N. Yamashita, H. Tanaka
    • Organizer
      The 3rd Asian Symposium on Water Reuse -Technology Renovation and Risk Management
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Removal characteristics of pharmaceuticals and personal care products in a membrane bioreactor2017

    • Author(s)
      Park, J., Yamashita, N., Tanaka, H.
    • Organizer
      The 3rd Asian Symposium on Water Reuse -Technology Renovation and Risk Management
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fouling control and biodegradability enhancement of pharmaceuticals and personal care products by coagulation-MBR process2017

    • Author(s)
      Park, J., Yamashita, N., Tanaka, H.
    • Organizer
      The 2nd International Conference on Biological Waste as Resource
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigation of main G Protein-Coupled Receptor-acting pharmaceuticals to trigger physiological activities in the wastewater of UK by the in vitro TGFα shedding assay2017

    • Author(s)
      Han ZHANG, Masaru IHARA, Seiya HANAMOTO, Norihide NAKADA, Monika D. JÜRGENS, Andrew C. JOHNSON, Hiroaki TANAKA
    • Organizer
      Micropol & Ecohazard 2017
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of the fate of photoproducts of ketoprofen in urban rivers2017

    • Author(s)
      Hanamoto S, Hasegawa E, Nakada N, Yamashita N, Tanaka H
    • Organizer
      Micropol & Ecohazard 2017
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Detection of physiological activities of antidepressant pharmaceuticals in wastewater by fluorescence based in vitro assay2017

    • Author(s)
      Masaru Ihara, Mariko O. Ihara, Hiroaki Tanaka
    • Organizer
      SETAC North America 38th Annual Meeting,
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prediction and management of emerging chemicals in the water environment2017

    • Author(s)
      Hiroaki TANAKA, Masaru IHARA, Norihide NAKADA, Han ZHANG, Fumiaki OGAWA, Seiya HANAMOTO, Andrew JOHNSON, Monika JÜRGENS
    • Organizer
      The 19th UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prioritization of main causative β-blockers for physiological activity in UK wastewater2017

    • Author(s)
      Han Zhang, Masaru Ihara, Seiya Hanamoto, Norihide Nakada, Monika D. Jurgens, Andrew C. Johnson, and Hiroaki Tanaka
    • Organizer
      The 19th UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Detection of physiological activities of antidepressant pharmaceuticals in wastewater by fluorescence based in vitro assay2017

    • Author(s)
      Masaru Ihara, Mariko O. Ihara, and Hiroaki Tanaka
    • Organizer
      The 19th UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fouling reduction and enhanced removal of pharmaceuticals and personal care products by coagulation-MBR process2017

    • Author(s)
      Park, J., Yamashita, N., Tanaka, H.
    • Organizer
      第54回下水道研究発表会
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 膜分離活性汚泥法における医薬品類の除去特性とメカニズム解明2017

    • Author(s)
      朴畯遠、山下尚之、田中宏明
    • Organizer
      第20回日本水環境学会シンポジウム
    • Related Report
      2016 Annual Research Report
  • [Presentation] In vitroアッセイによる下水中の抗うつ薬様物質の生理活性の検出2017

    • Author(s)
      井原 賢、井原 満理子、加藤 大典、Han Zhang、田中 宏明
    • Organizer
      第20回環境ホルモン学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 水生生物への影響が懸念される医薬品:下水・河川水中の医薬品生理活性からの考察2016

    • Author(s)
      井原賢、花本征也、Zhang Han、田中宏明
    • Organizer
      第50回日本水環境学会年会
    • Place of Presentation
      徳島
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Comparison of Physiological Activities of Pharmaceuticals in Primary Effluent of Wastewater Treatment Plant between Japan and UK2016

    • Author(s)
      Han ZHANG, Masaru IHARA, Seiya HANAMOTO, Norihide NAKADA, Monika D. JÜRGENS, Andrew C. JOHNSON, Hiroaki TANAKA
    • Organizer
      第50回日本水環境学会年会
    • Place of Presentation
      徳島
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 河川における医薬品類の底質への移行に関する検討2016

    • Author(s)
      花本征也、中田典秀、山下尚之、田中宏明
    • Organizer
      第50回日本水環境学会年会
    • Place of Presentation
      徳島
    • Year and Date
      2016-03-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 下水処理水が流入する都市河川におけるケトプロフェンとその光分解産物の濃度変動調査2016

    • Author(s)
      長谷川英資、花本征也、中田典秀、山下尚之、田中宏明
    • Organizer
      第50回日本水環境学会年会
    • Place of Presentation
      徳島
    • Year and Date
      2016-03-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] 水環境改善に貢献してきた下水道が 今後の持続可能な都市水循環系構築に 果たすべき課題2016

    • Author(s)
      田中宏明
    • Organizer
      大阪府下水道協会幹部職員研修会
    • Place of Presentation
      シティプラザ大阪
    • Year and Date
      2016-02-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 河川水に含まれる医薬品生理活性の測定2015

    • Author(s)
      井原賢、花本征也、Zhang Han、田中宏明
    • Organizer
      第18回環境ホルモン学会第18回研究発表会
    • Place of Presentation
      栃木
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 下水中のエストロゲン様作用、抗エストロゲン作用による複合影響2015

    • Author(s)
      井原賢、北村友一、Vimal Kumar、Park Chang-Beom、大野満理子、Lee Sang-Jung、山下尚之、宮川信一、井口泰泉、岡本誠一郎、鈴木穣、田中宏明
    • Organizer
      第18回環境ホルモン学会第18回研究発表会
    • Place of Presentation
      栃木
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Fate of endocrine disrupting chemicals and emerging contaminants in the environment and their remediation2015

    • Author(s)
      Hiroaki TANAKA, Masaru IHARA, Seiya HANAMOTO, Seiichiro OKAMOTO, Andrew JOHNSON, Monika JÜRGENS
    • Organizer
      2015 UK-Japan Workshop on Endocrine Disrupting Chemicals
    • Place of Presentation
      札幌
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Estimation of wastewater burden and effectiveness of sewage treatment in the Thames Basin, UK2015

    • Author(s)
      N. Nakada, S. Hanamoto, M. Jürgens, M.J. Bowes, A.C. Johnson, H. Tanaka
    • Organizer
      IWA Micropol & Ecohazard 2015
    • Place of Presentation
      Singapore
    • Year and Date
      2015-11-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison of physiological activities of pharmaceuticals in secondary effluent between UK and Japan2015

    • Author(s)
      Han ZHANG, Masaru IHARA, Seiya HANAMOTO, Norihide NAKADA, Monika D. JÜRGENS, Andrew C. JOHNSON, Hiroaki TANAKA
    • Organizer
      IWA Micropol & Ecohazard 2015
    • Place of Presentation
      Singapore
    • Year and Date
      2015-11-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 環境微量汚染物質による水質汚濁問題2015

    • Author(s)
      田中宏明
    • Organizer
      BYQシンポジウム「琵琶湖・淀川の水質現状と課題」
    • Place of Presentation
      國民會館 12 階大ホール 大阪市
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] In vivo vitellogenin expression in male medaka induced by wastewater is determined by the balance between estrogenic and antiestrogenic activities2015

    • Author(s)
      M. Ihara, T. Kitamura, V. Kumar, C. B. Park, M. O. Ihara, S. J. Lee, N. Yamashita, S. Miyagawa, T. Iguchi, S. Okamoto, Y. Suzuki, and Hiroaki Tanaka
    • Organizer
      International Conference on Emerging Trends in Biotechnology - the 11th Convention of the Biotech Research Society
    • Place of Presentation
      Lisbon, Portugal
    • Year and Date
      2015-11-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 河川流下過程における医薬品類の消長2015

    • Author(s)
      中田典秀、花本征也、田中宏明
    • Organizer
      第18回日本水環境学会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2015-09-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] Water, Health, the Environment and Sanitation, A Japanese Perspective2015

    • Author(s)
      Hiroaki Tanaka
    • Organizer
      Sixth Chemical Sciences & Society Symposium (CS3)
    • Place of Presentation
      Leipzig, Germany
    • Year and Date
      2015-09-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 河川流下過程における医薬品類の減衰:実態把握とメカニズム解明2015

    • Author(s)
      花本征也、中田典秀、山下尚之、田中宏明
    • Organizer
      第17回日本水環境学会シンポジウム講演集
    • Place of Presentation
      彦根市
    • Year and Date
      2015-09-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] 身近な“水”についての課題と展望2015

    • Author(s)
      田中宏明
    • Organizer
      2015年度日立技術士会 関西RG講演会
    • Place of Presentation
      大阪
    • Year and Date
      2015-09-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 河川水からの医薬品生理活性の検出2015

    • Author(s)
      井原賢、花本征也、Han Zhang、田中宏明
    • Organizer
      第21回日本環境毒性学会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 持続可能な水環境を形成するための下水道の課題と期待2015

    • Author(s)
      田中宏明
    • Organizer
      平成27年度 産総研 エネルギー・環境シンポジウム「水資源の現状と循環利用のための技術展望~アジアに向けた技術貢献を目指して~」
    • Place of Presentation
      機械振興会館、東京
    • Year and Date
      2015-09-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Success of municipal wastewater management and future challenges in Japan2015

    • Author(s)
      Hiroaki Tanaka
    • Organizer
      Asia-Europe Meeting (ASEM) Seminar on Sustainable Management of Wastewater and Sanitation
    • Place of Presentation
      Singapore
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Detection and Comparison of Physiological Activities of Pharmaceuticals in Secondary Effluent between UK and Japan2015

    • Author(s)
      Han Zhang, Masaru IHARA, Seiya HANAMOTO, Norihide NAKADA, Hiroaki TANAKA
    • Organizer
      The 24rd KAIST-KU-NTU-NUS (KKNN) Symposium on Environmental Engineering
    • Place of Presentation
      National Taiwan University
    • Year and Date
      2015-06-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Detection of physiological activities of pharmaceuticals in river water in Japan2015

    • Author(s)
      Masaru Ihara, Han Zhang, Seiya Hanamoto, and Hiroaki Tanaka
    • Organizer
      SETAC Europe 25th Annual Meeting
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2015-05-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 河川における医薬品類の底質への収着に関する検討2015

    • Author(s)
      花本征也、中田典秀、山下尚之、田中宏明
    • Organizer
      第49回日本水環境学会年会
    • Place of Presentation
      金沢市
    • Year and Date
      2015-03-16 – 2015-03-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comparison of physiological activities of pharmaceuticals in secondary effluent in UK and Japan2015

    • Author(s)
      Han ZHANG, Masaru IHARA, Seiya HANAMOTO, Norihide NAKADA, Hiroaki TANAKA
    • Organizer
      第49回日本水環境学会年会
    • Place of Presentation
      金沢市
    • Year and Date
      2015-03-16 – 2015-03-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] "Comparison of physiological activities of pharmaceuticals in UK and Japan wastewater by TGFα shedding assay2014

    • Author(s)
      "Han ZHANG, Masaru IHARA, Seiya HANAMOTO, Norihide NAKADA, Hiroaki TANAKA
    • Organizer
      第17回環境ホルモン学会
    • Place of Presentation
      東京都
    • Year and Date
      2014-12-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] "Mechanistical consideration of natural attenuation of pharmaceuticals and personal care products2014

    • Author(s)
      Seiya Hanamoto, Norihide Nakada, Naoyuki Yamashita, Hiroaki Tanaka
    • Organizer
      20th UK-Japan Workshop on Endrine Disruting Chemicals
    • Place of Presentation
      Bath, UK
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Natural attenuation of pharmaceuticals and personal care products in Thames River2014

    • Author(s)
      S. Hanamoto, N. Nakada, M.D. Jürgens, A. C. Johnson, N. Yamashita and H. Tanaka
    • Organizer
      20th UK-Japan Workshop on Endrine Disruting Chemicals
    • Place of Presentation
      Bath, UK
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] "Detection of physiological activities of G protein-coupled receptor-acting pharmaceuticals2014

    • Author(s)
      "Masaru Ihara, Asuka Inoue, Seiya Hanamoto, Han Zhang, Jyunken Aoki, and Hiroaki Tanaka
    • Organizer
      20th UK-Japan Workshop on Endrine Disruting Chemicals
    • Place of Presentation
      Bath, UK
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] "Change of estrogenic activity of wastewater; comparison among in vitro ERα reporter gene assay,2014

    • Author(s)
      "Masaru Ihara, Tomokazu Kitamura, Vimal Kumar, ChangBeom Park, Mariko O. Ihara, SunJun Lee, Kentarou Kobayashi, Hiroo Takabatake, Hiroaki Tanaka, Yuji Tanaka, Naoyuki Yamashita, Shinichi Miyagawa, Taisen Iguchi, Seiichiro Okamoto, Yutaka Suzuki, and Hiroaki Tanaka
    • Organizer
      20th UK-Japan Workshop on Endrine Disruting Chemicals
    • Place of Presentation
      Bath, UK
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Detection and comparison of physiological activities of pharmaceuticals in wastewater in UK and Japan2014

    • Author(s)
      Han ZHANG, Masaru IHARA, Seiya HANAMOTO, Norihide NAKADA, Hiroaki TANAKA
    • Organizer
      20th UK-Japan Workshop on Endrine Disruting Chemicals
    • Place of Presentation
      Bath, UK
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Fate of endocrine disrupting chemicals and emerging contaminants in the environment and their remedeation2014

    • Author(s)
      Hiroaki TANAKA, Seiichiro OKAMOTO, Andrew JOHNSON
    • Organizer
      20th UK-Japan Workshop on Endrine Disruting Chemicals
    • Place of Presentation
      Bath, UK
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Sorption of pharmaceuticals from river water onto sediment: harnessing river as treatment system in water reuse2014

    • Author(s)
      Seiya Hanamoto, Norihide Nakada, Naoyuki Yamashita, Hiroaki Tanaka
    • Organizer
      2nd International Symposium on Development and Evaluation of Water Reuse Technologies for the Establishment of 21st Century Type Water Cycle System
    • Place of Presentation
      Danang, Vietnam
    • Year and Date
      2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] The Fate of selected Pharmaceuticals in a section of the River Thames and in Sewage Treatment Plants2014

    • Author(s)
      S. Hanamoto, N. Nakada, M.D. Jürgens, A. C. Johnson, N. Yamashita, H. Tanaka
    • Organizer
      IWA World Water Congress,Lisbon, Porogal
    • Place of Presentation
      Lisbon, Portogal
    • Year and Date
      2014-09-21 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Detection of Estrogenic and Anti-Estrogenic Activities in Wastewater by in vitro ERalpha Reporter Gene Assay2014

    • Author(s)
      Masaru Ihara, Mariko O. Ihara, Vimal Kumar, Masanori Narumiya, Seiya Hanamoto, Norihide Nakada, Naoyuki Yamashita, Shinichi Miyagawa, Taisen Iguchi, Hiroaki Tanaka
    • Organizer
      SETAC Asia/Pacific 2014 conference,Adelaide, Australia
    • Place of Presentation
      Adelaide, Australia
    • Year and Date
      2014-09-14 – 2014-09-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of Predictive Model of Pharmaceuticals and Estrogens in a Korean River Water2014

    • Author(s)
      SangJung Lee, Norihide Nakada, YongJu Jo, A-Reum Jung, IlHoe Kim, Ji Woong Kim, SeMi Yoon, IhnSup Han, and Hiroaki Tanaka
    • Organizer
      13th IWA Specialist Conference on Watershed and River Basin Management
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-09-09 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 下水中の医薬品類の生理活性の検出2014

    • Author(s)
      井原賢、井上飛鳥、花本征也、青木淳賢、田中宏明
    • Organizer
      第36回京都大学環境衛生工学研究会シンポジウム
    • Place of Presentation
      京都市
    • Year and Date
      2014-07-31
    • Related Report
      2014 Annual Research Report
  • [Book] 生物応答を用いた排水評価・管理手法の国内外最新動向2014

    • Author(s)
      田中宏明, 井原賢 (分担執筆)
    • Publisher
      NTS
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

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