Lung cancer probability and prognostic prediction using a large-scale CT image database

• Project/Area Number: 26280107
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Life / Health / Medical informatics
• Research Institution: The University of Tokushima
• Principal Investigator: Kawata yoshiki 徳島大学, 大学院理工学研究部, 准教授 (70274264)
• Co-Investigator(Kenkyū-buntansha): 仁木 登 徳島大学, ソシオテクノサイエンス研究部, 教授 (80116847) ; 大松 広伸 国立研究開発法人国立がん研究センター, 東病院, 副科長 (40415518) ; 楠本 昌彦 国立研究開発法人国立がん研究センター, 東病院, 科長 (90252767)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000); Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: 肺がんの画像診断法 / 肺がん病態の時空間的な解析法 / 肺がん候補の悪性度推定法 / 肺がん候補の予後予測法 / 経時拡大CT画像 / 経時拡大CT 画像

Outline of Final Research Achievements

Purpose of this research was to develop prediction models for lung cancer probability and prognosis through quantitative analyses of a large-scale CT image database. We strove to the following three major research issues: (1) establishment of a large-scale CT image database in which thoracic CT images with a large field-of-view, clinicopathological information, and prognostic information were included, (2) development of CT features which can represent tumor phenotypes quantitatively, (3) development of prediction models for lung cancer probability and prognosis. Our achievements may accelerate the identification of reliable and meaningful quantitative imaging biomarkers to develop the core technologies of estimating lung cancer probability and prognosis using preoperative CT images.

Research Products

• [Journal Article] 計算解剖モデルに基づく診断支援 (2014)
  • Author(s): 仁木登，河田佳樹，鈴木秀宣，松廣幹雄
  • Journal Title: INNERVISION Volume: 29 Pages: 19-21
  • NAID: 130000886607
• [Presentation] 拡大CT画像を用いた肺腺がん（病期IA）の周囲構造特徴と再発リスクの関連 (2017)
  • Author(s): 河田佳樹，仁木登，楠本昌彦，大松広伸，青景圭樹，石井源一郎，松元祐司，土田敬明，江口研二
  • Organizer: 第24回日本CT検診学会学術集会
  • Place of Presentation: あわぎんホール （徳島県徳島市）
  • Year and Date: 2017-02-03
• [Presentation] 拡大CT画像を用いた肺がんのコンピュータ支援診断 (2017)
  • Author(s): 河田佳樹，仁木登，大松広伸，楠本昌彦，青景圭樹，土田敬明，松元祐司，江口研二，金子昌弘
  • Organizer: 第9回呼吸機能イメージング研究会学術集会
  • Place of Presentation: 京都大学 百周年時計台記念館 （京都府京都市）
  • Year and Date: 2017-01-27
• [Presentation] Multiscale function and pathology modeling of respiratory system (2016)
  • Author(s): N.Niki
  • Organizer: The 55th Annual Conference of Japanese Society for Medical and Biological Engineering
  • Place of Presentation: Toyama International Conference Center (Toyama-city, Toyama)
  • Year and Date: 2016-04-26
  • Int'l Joint Research
• [Presentation] Preliminary study of visualizing membrane structures of spiculated pulmonary nodules in three-dimensional thoracic CT images (2016)
  • Author(s): Y.Kawata, N.Niki, H.Ohmatsu, K.Aokage, M.Kusumoto, T.Tsuchida, K.Eguchi, M.Kaneko:
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Town & Country Resort and Convention Center (San Diego, California, USA)
  • Year and Date: 2016-02-27
  • Int'l Joint Research
• [Presentation] Three-dimensional morphological analysis of spiculated pulmonary nodules in thoracic CT images (2016)
  • Author(s): Y.Kawata, N.Niki, H.Ohmatsu, K.Aokage, M.Kusumoto, T.Tsuchida, K.Eguchi, M.Kaneko
  • Organizer: 1st Asia Oceania Workshop of Pulmonary Functional Imaging combined with 8th Japanese Society of Pulmonary Functional Imaging
  • Place of Presentation: Awaji Yumebutai International Conference Center (Awaji City, Hyogo, Japan)
  • Year and Date: 2016-01-29
  • Int'l Joint Research
• [Presentation] （特別講演）胸部CT画像解析と臨床利用 (2015)
  • Author(s): 仁木登
  • Organizer: 第17回医用画像認知研究会
  • Place of Presentation: 京都キャンパスプラザ（京都府京都市）
  • Year and Date: 2015-08-29
• [Presentation] Nonlinear dimensionality reduction of CT histogram based feature space for predicting recurrence-free survival in non-small-cell lung cancer (2015)
  • Author(s): Ｙ.Kawata, N.Niki, H.Ohmatsu, K.Aokage, M.Kusumoto, T.Tsuchida, K.Eguchi, M.Kaneko
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Renaissance Orlando (Orlando, Florida, United States)
  • Year and Date: 2015-02-21 – 2015-02-26
• [Presentation] Quantitative assessment of smoking-induced emphysema progression in longitudinal CT screening for lung cancer (2015)
  • Author(s): H.Suzuki, R.Mizuguchi, M.Matsuhiro, Y.Kawata, N.Niki, Y.Nakano, H.Ohmatsu, M.Kusumoto, T.Tsuchida, K.Eguchi, M.Kaneko, N.Moriyama
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Renaissance Orlando (Orlando, Florida, United States)
  • Year and Date: 2015-02-21 – 2015-02-26
• [Presentation] Peripleural lung disease detection based on multi-slice CT images (2015)
  • Author(s): M.Matsuhiro, H.Suzuki, Y.Kawata, N.Niki, Y.Nakano, H.Ohmatsu, M.Kusumoto, T.Tsuchida, K.Eguchi, M.Kaneko
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Renaissance Orlando (Orlando, Florida, United States)
  • Year and Date: 2015-02-21 – 2015-02-26
• [Presentation] Microstructure analysis of the pulmonary acinus using a synchrotron radiation CT (2015)
  • Author(s): Y.Tokumoto, K.Minami, Y.Kawata, N.Niki, K.Umetani, Y.Nakano, H.Sakai, H.Ohmatsu, H.Itoh
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Renaissance Orlando (Orlando, Florida, United States)
  • Year and Date: 2015-02-21 – 2015-02-26
• [Presentation] CAD工学的課題解決から臨床応用に向けて (2014)
  • Author(s): 仁木登
  • Organizer: 日本医用画像工学会大会
  • Place of Presentation: 東京慈恵会医科大学（東京都港区）
  • Year and Date: 2014-07-25
  • Invited
• [Presentation] CADe and CADx for lung cancer CT images (2014)
  • Author(s): N.Niki
  • Organizer: CARS International Journal of Computer Assisted Radiology and Surgery
  • Place of Presentation: Fukuoka International Convention Center （福岡県福岡市）
  • Year and Date: 2014-06-27
  • Invited
• [Presentation] Recurrence-free survival prediction of non-small cell lung cancer based on a nonparametric Bayesian analysis of CT histograms (2014)
  • Author(s): Y.Kawata, N.Niki, H.Ohmatsu, K.Aokage, M.Kusumoto, T.Tsuchida, M.Satake, K.Eguchi, M.Kaneko, N.Moriyama
  • Organizer: CARS International Journal of Computer Assisted Radiology and Surgery
  • Place of Presentation: Fukuoka International Convention Center （福岡県福岡市）
  • Year and Date: 2014-06-25 – 2014-06-28
• [Presentation] Automatic extraction of abdominal blood vessel through the portal phase of a CT dataset (2014)
  • Author(s): A.Maklad, M.Matsuhiro, H.Suzuki, Y.Kawata, N.Niki, M.Satake, N.Moriyama, T.Utsunomiya, M.Shimada:
  • Organizer: CARS International Journal of Computer Assisted Radiology and Surgery
  • Place of Presentation: Fukuoka International Convention Center （福岡県福岡市）
  • Year and Date: 2014-06-25 – 2014-06-28
• [Presentation] 肺がんのマルチスケールCT画像解析と臨床応用 (2014)
  • Author(s): 仁木登
  • Organizer: 第67回岐阜呼吸器疾患研究会
  • Place of Presentation: 岐阜県医師会館（岐阜県岐阜市）
  • Year and Date: 2014-05-31
  • Invited