| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Outline of Final Research Achievements |
The aims of this study are to develop an original targeting ligand to adipose vasculature and a new functional medicine for obesity treatment. Regarding the original ligand development, we succeeded to identify a novel single-strand DNA aptamer which has in vivo targeting ability to the adipose vasculature in vivo. In addition, we also proved that the DNA aptamer-modified nano DDS (drug delivery system) has significant anti-obesity effects in the mouse model of diet-induced obesity. Next, we focused curcumin as a new functional medicine and succeeded to establish an efficient methodology for preparation of curcumin-loaded nano DDS. We also proved that the curcumin-loaded nano DDS has pro-apoptotic ability in vitro. In the near future, we proceed to in vivo functional assessments of a novel system composed of the original ligands and curcumin for treatment of obesity.
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