Nanomix for a future treatment approach of metabolic syndrome
Project/Area Number |
26282132
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Biomedical engineering/Biomaterial science and engineering
|
Research Institution | National Institute of Advanced Industrial Science and Technology (2016) Hokkaido University (2014-2015) |
Principal Investigator |
Kajimoto Kazuaki 国立研究開発法人産業技術総合研究所, 健康工学研究部門, 主任研究員 (10416216)
|
Co-Investigator(Kenkyū-buntansha) |
櫻井 遊 北海道大学, 薬学研究科(研究院), 特任助教 (00707234)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
|
Keywords | ドラッグデリバリーシステム / リポソーム / 肥満 / 脂肪組織 / 血管 / ナノテクノロジー / オミックス創薬 / メタボリックシンドローム |
Outline of Final Research Achievements |
The aims of this study are to develop an original targeting ligand to adipose vasculature and a new functional medicine for obesity treatment. Regarding the original ligand development, we succeeded to identify a novel single-strand DNA aptamer which has in vivo targeting ability to the adipose vasculature in vivo. In addition, we also proved that the DNA aptamer-modified nano DDS (drug delivery system) has significant anti-obesity effects in the mouse model of diet-induced obesity. Next, we focused curcumin as a new functional medicine and succeeded to establish an efficient methodology for preparation of curcumin-loaded nano DDS. We also proved that the curcumin-loaded nano DDS has pro-apoptotic ability in vitro. In the near future, we proceed to in vivo functional assessments of a novel system composed of the original ligands and curcumin for treatment of obesity.
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Report
(4 results)
Research Products
(15 results)