| Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
We aim to establish a proof of concept of novel targeting to acute brain ischemic stroke using macromolecular MRI contrast agents. We successfully prepared two types of contrast agents; polymeric micelle type and non-micelle forming type. Using these agents, we observed their significantly rapid accumulation at the ischemic sites in T1-weighted MR images. Owing to very distinct images with a long-time-lasting character, MRI analyses by the use of macromolecular contrast agents may realize risk prediction of brain hemorrhage induced by the t-PA therapy that is conducted against acute brain ischemic stroke.
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