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The solution of neuronal basis for long-term benefit of CI therapy and, construction of more beneficial treatment strategy for upper-extremity deficit in chronic stroke patients.

Research Project

Project/Area Number 26282158
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionHyogo Medical University

Principal Investigator

Domen Kazuhisa  兵庫医科大学, 医学部, 教授 (50207685)

Co-Investigator(Kenkyū-buntansha) 小山 哲男  兵庫医科大学, 医学部, 特別招聘教授 (40538237)
内山 侑紀  兵庫医科大学, 医学部, 助教 (50725992)
池田 紗綾香  兵庫医科大学, 医学部, 助教 (70751436)
高橋 香代子  北里大学, 医療衛生学部, 講師 (70572155)
友利 幸之介  長崎大学, 医歯(薬)学総合研究科, 研究員 (90381681)
古河 慶子  兵庫医科大学, 医学部, 助教 (10412016)
足立 清香  兵庫医科大学, 医学部, 助教 (70731694)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Keywords脳卒中
Outline of Final Research Achievements

Deliverables of this study consist of 4 parts. First, We investigated on the nerve fiber related the long-term benefit of CI therapy. Consequently, we found 7 important nerve fivers involved the upper-extremity motor control and learning. Secondly, We developed the multiple intervention using robotic therapy, electrical stimulation therapy, and CI therapy for severe upper-extremity deficit. Consequently, we found that the multiple intervention significantly improved the paretic upper-extremity function. Thirdly, We developed the application termed "ADOC-H" to quantify of behavioral strategy involved the long-term benefit of CI therapy. Forth, we applied the fostered methodology(robotic therapy and electrical stimulation therapy) for upper-extremity deficit in a treatment of lower-extremity deficit. Consequently, two new treatments for lower-extremity deficit significantly improved the function or walking speed.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(14 results)

All 2017 2016 2015 2014

All Journal Article (8 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 4 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] Differences in neural pathways are related to the short- or long-term benefits of constraint-induced movement therapy in patients with chronic stroke and hemiparesis: a pilot cohort study2017

    • Author(s)
      Takebayashi Takashi、Marumoto Kohei、Takahashi Kayoko、Domen Kazuhisa
    • Journal Title

      Topics in Stroke Rehabilitation

      Volume: 25 Pages: 203-208

    • DOI

      10.1080/10749357.2017.1399231

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Improvement of Upper Extremity Deficit after Constraint-Induced Movement Therapy Combined with and without Preconditioning Stimulation Using Dual-hemisphere Transcranial Direct Current Stimulation and Peripheral Neuromuscular Stimulation in Chronic Stroke Patients: A Pilot Randomized Controlled Trial2017

    • Author(s)
      Takebayashi Takashi、Takahashi Kayoko、Moriwaki Misa、Sakamoto Tomosaburo、Domen Kazuhisa
    • Journal Title

      Frontiers in Neurology

      Volume: 8 Pages: 568-568

    • DOI

      10.3389/fneur.2017.00568

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 重度から中等度上肢麻痺を呈した慢性期脳卒中患者に対する多角的介入におけるロボット療法の実際2017

    • Author(s)
      竹林崇,天野暁,花田恵介,内山侑紀,道免和久
    • Journal Title

      作業療法

      Volume: 36 Pages: 148-158

    • NAID

      40021183905

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 重度から中等度麻痺を停止た慢性期脳卒中患者に対する多角的介入におけるロボット療法の実際2017

    • Author(s)
      竹林崇、天野暁、花田恵介、内山侑紀、道免和久
    • Journal Title

      作業療法

      Volume: 36 Pages: 148-158

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Constraint-induced movement therapy with"Aid for Decision-making in Occupation Choice for Hand"2015

    • Author(s)
      大谷愛、竹林崇、友利幸之介、道免和久
    • Journal Title

      作業療法ジャーナル

      Volume: 49 Issue: 11 Pages: 1141-1145

    • DOI

      10.11477/mf.5001200397

    • ISSN
      0915-1354
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A one-year follow-up after modified constraint-induced movement therapy for chronic stroke patients with paretic arm: a prospective case series study.2015

    • Author(s)
      Takebayashi T, Amano S, Hanada K, Umeji A, Takahashi K, Marumoto K, Kodama N, Koyama T, Domen K
    • Journal Title

      Topics in stroke rehabilitation

      Volume: 22 Pages: 18-25

    • DOI

      10.1179/1074935714z.0000000028

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Constraint-induced movement therapy after injection of Botulinum toxin type A for a patient with chronic stroke: One-year follow-up case report.2015

    • Author(s)
      Amano S, Takebayashi T, Hanada K, Umeji A, Marumoto K, Furukawa K, Domen K
    • Journal Title

      Physical therapy

      Volume: epub ahead of print

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 脳卒中後慢性期重度上肢麻痺に対するボツリヌス毒素A型施注後のロボット療法とmodified Constraint-induced movement therapyの併用 探索的ケースシリーズ2014

    • Author(s)
      竹林崇,花田恵介,梅地篤史,天野暁,丸本浩平,道免和久
    • Journal Title

      作業療法ジャーナル

      Volume: 48 Pages: 1339-1346

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Effect of Gait Exercise Assist Robot for Stroke Patients in a Convalescent Rehabilitation Ward: Comparison between Actual and Predicted Functional Independence Measure2016

    • Author(s)
      Yuki Uchiyama, Mayuka Fukai, Mizuho Kagoshima, Yousuke Wada, Kazuhisa Domen
    • Organizer
      Asian Prosthetic and Orthotic Scientific Meeting 2016
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-11-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] GEAR による歩行訓練を実施した回復期脳卒中片麻痺の 3 例2016

    • Author(s)
      内山 侑紀、荻野 智之、波戸本 理絵、高橋 和子、和田 陽介、道免 和久
    • Organizer
      第53回 日本リハビリテーション医学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-06-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] Aid for Decision-making in Occupation choice for hand (ADOC-H)紙面版のCI療法における試用2015

    • Author(s)
      大谷愛、竹林崇、友利幸之介、道免和久
    • Organizer
      第49回日本作業療法学会
    • Place of Presentation
      神戸ポートピアホテル・神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-06-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Relationship between diffusion tensor image (DTI) and long-term outcome in patients after cerebral infarction received constraint-induced movement therapy2014

    • Author(s)
      Takebayashi T, Hanada K, Amano S, Marumoto K, Domen K
    • Organizer
      World federation of occupational therapies
    • Place of Presentation
      横浜
    • Year and Date
      2014-06-18 – 2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 上肢機能再建から活動へ2014

    • Author(s)
      道免和久
    • Organizer
      第51回日本リハビリテーション医学学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-06-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 脳卒中後上肢麻痺に対するReoGo therapyを用いた治療介入2014

    • Author(s)
      竹林崇、花田恵介、道免和久
    • Organizer
      第51回日本リハビリテーション医学学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-06-05
    • Related Report
      2014 Annual Research Report
    • Invited

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Published: 2014-04-04   Modified: 2019-03-29  

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