Magnetoencephalography study on physical fatigue

• Project/Area Number: 26282185
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Osaka City University
• Principal Investigator: Tanaka Masaaki 大阪市立大学, 大学院医学研究科, 講師 (60382199)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000); Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
• Keywords: スポーツ生理学 / 疲労 / 慢性疲労 / 神経科学

Outline of Final Research Achievements

The purpose of this study was to elucidate the neural basis of physical fatigue. I tried to elucidate the neural mechanisms of physical fatigue, which has dynamic and interactive nature, using magnetoencephalography. We clarified the interactive neural mechanisms of inhibition and facilitation systems using magnetoencephalography and other various evaluation methods in healthy volunteers. In addition, we clarified the effect of chronic fatigue on the neural mechanisms of physical fatigue using magnetoencephalography and other various evaluation methods in healthy volunteers and those with chronic fatigue. Our results would contribute to total understanding of the neural mechanisms of fatigue.

Research Products

• [Journal Article] Visual food stimulus changes resting oscillatory brain activities related to appetitive motive. (2016)
  • Author(s): Yoshikawa, T., Tanaka, M., Ishii, A., Yamano, Y., Watanabe, Y.
  • Journal Title: Behav. Brain. Funct. Volume: 12 Issue: 1 Pages: 26-26
  • DOI: 10.1186/s12993-016-0110-3
  • NAID: 120006371281
  • Peer Reviewed / Open Access
• [Journal Article] Effect of water pillar shower bathing on sleep onset latency. (2016)
  • Author(s): Matsushita, H., Tanaka, M., Kondo, M., Komatsu, F., Ueyama, I., Nakajima, Y., Tanaka, S., Sato, M., Ishii, A., Watanabe, Y.
  • Journal Title: Medical Science and Technology Volume: 57 Pages: 88-94
  • DOI: 10.12659/mst.900800
  • Peer Reviewed / Open Access
• [Journal Article] Neural mechanisms to predict subjective level of fatigue in the future: a magnetoencephalography study (2016)
  • Author(s): Ishii, A., Tanaka, M., Watanabe, Y.
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 25097-25097
  • DOI: 10.1038/srep25097
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The neural mechanisms of re-experiencing physical fatigue sensation: a magnetoencephalography study (2016)
  • Author(s): Ishii, A., Tanaka, M., Watanabe, Y.
  • Journal Title: Exp Brain Res Volume: 印刷中
  • Peer Reviewed / Open Access
• [Journal Article] Roles of the right dorsolateral prefrontal cortex during physical fatigue: a magnetoencephalographic study (2016)
  • Author(s): Tanaka, M., Ishii, A., Watanabe, Y.
  • Journal Title: Fatigue: Biomedicine, Health & Behavior Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Neural effect of physical fatigue on mental fatigue: A magnetoencephalography study (2016)
  • Author(s): Tanaka, M., Ishii, A., Watanabe, Y.
  • Journal Title: Fatigue: Biomedicine, Health & Behavior Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Neural basis of individual differences in the response to mental stress: a magnetoencephalography study (2015)
  • Author(s): Yamano E., et al.
  • Journal Title: Brain Imaging Behav Volume: November 19 Issue: 4 Pages: 1160-1171
  • DOI: 10.1007/s11682-015-9479-0
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Fronthier studies on fatigue, autonomic nerve dysfunction,and sleep-rhythm disorder (2015)
  • Author(s): Masaaki Tanaka, Seiki Tajima, Kei Mizuno, Akira Ishii, Yukuo Konishi, Teruhisa Miike, Yasuyoshi Watanabe
  • Journal Title: The Journal of Physiological Sciences Volume: 65(6) Issue: 6 Pages: 483-498
  • DOI: 10.1007/s12576-015-0399-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Fatigue in the central nervous system (2015)
  • Author(s): Tanaka, M., Ishii, A., Watanabe, Y.
  • Journal Title: Austin J Clin Neurol Volume: 2 Pages: 1020-1020
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Physical fatigue increases neural activation during eyes-closed state: a magnetoencephalography study (2015)
  • Author(s): Tanaka, M., Ishii, A., Watanabe, Y.
  • Journal Title: Behav Brain Funct Volume: 11 Issue: 1 Pages: 35-35
  • DOI: 10.1186/s12993-015-0079-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Less efficient and costly processes of frontal cortex in childhood chronic fatigue syndrome (2015)
  • Author(s): Mizuno, K., Tanaka, M., Tanabe, H.C., Joudoi, T., Kawatani, J., Shigihara, Y., Tomoda, A., Miike, T., Imai-Matsumura, K., Sadato, N., Watanabe, Y.
  • Journal Title: NeuroImage: Clinical Volume: 9 Pages: 355-368
  • Peer Reviewed / Open Access
• [Journal Article] Effects of mental fatigue on brain activity and cognitive performance: a magnetoencephalography study (2015)
  • Author(s): Tanaka, M., Ishii, A., Watanabe, Y.
  • Journal Title: Anatomy & Physiology: Current Research Volume: 5 Pages: 4-4
  • DOI: 10.4172/2161-0940.s4-002
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Imaging the passionate stage of romantic love by dopamine dynamics (2015)
  • Author(s): Takahashi, K., Mizuno, K., Sasaki, A., Wada, Y., Tanaka, M., Ishii, A., Tajima, K., Watanabe, K., Tsuyuguchi, N., Zeki, S., Watanabe, Y.
  • Journal Title: Front Hum Neurosci Volume: 9 Pages: 191-191
  • DOI: 10.3389/fnhum.2015.00191
  • Peer Reviewed / Open Access
• [Journal Article] The neural mechanisms of re-experiencing mental fatigue sensation: a magnetoencephalography study (2015)
  • Author(s): Ishii A, Karasuyama T, Kikuchi T, Tanaka M, Yamano E, Watanabe Y
  • Journal Title: PLoS One Volume: 10 Issue: 3 Pages: 1-11
  • DOI: 10.1371/journal.pone.0122455
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hazardous effects of light stimulation in the central nervous system (2014)
  • Author(s): Tanaka, M., Ishii, A., Watanabe, Y.
  • Journal Title: Austin J Clin Neurol Volume: 1 Pages: 4-4
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Regulatory mechanism of performance in chronic cognitive fatigue (2014)
  • Author(s): Tanaka, M., Ishii, A., Watanabe, Y.
  • Journal Title: Med Hypotheses Volume: 82 Issue: 5 Pages: 567-571
  • DOI: 10.1016/j.mehy.2014.02.013
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Neural effects of mental fatigue caused by continuous attention load: A magnetoencephalography study (2014)
  • Author(s): Tanaka, M., Ishii, A., Watanabe, Y.
  • Journal Title: Brain Res Volume: 1561 Pages: 60-66
  • DOI: 10.1016/j.brainres.2014.03.009
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 急性身体的疲労によって誘発される脳活動の亢進：脳磁図研究 (2016)
  • Author(s): 田中雅彰、石井聡、山野恵美、渡邊恭良
  • Organizer: 第12回日本疲労学会総会・学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Invited
• [Presentation] 脳磁図計を用いた新規開発香料の抗疲労効果に関する検討 (2016)
  • Author(s): 2.山野恵美、田中雅彰、石井聡、齋藤菜穂子、中村純二、渡邊恭良
  • Organizer: 第12回日本疲労学会総会・学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Invited
• [Presentation] PET Imaging of Dopamine Dynamics in Romantic Love (2015)
  • Author(s): Takahashi, K., Mizuno, K., Sasaki, T.A., Wada, Y., Tanaka, M., Ishii, A., Tajima, K., Tsuyuguchi, N., Watanabe, K., Zeki, S., Watanabe, Y.
  • Organizer: World Molecular Imaging Congress (WMIC) 2015
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2015-09-02
  • Int'l Joint Research
• [Presentation] First-in-Human study of [18F]AA-7: A novel PET tracer for imaging L-type amino acid transporter 1 (LAT1)-positive tumors (2015)
  • Author(s): Nozaki, S., Oshita, T., Nakatani, Y., Nakatani, Y., Sasano, Y., Yamamoto, K., Hume, W.E., Wada, Y., Ishii, A., Tanaka, M., Shiomi, S., Tsuyuguchi, N., Kodama, K., Watanabe, Y.
  • Organizer: World Molecular Imaging Congress (WMIC) 2015
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2015-09-02
  • Int'l Joint Research
• [Presentation] 脳磁図を用いた疲労の脳科学研究 (2015)
  • Author(s): 田中雅彰、石井聡、山野恵美、渡辺恭良
  • Organizer: 第10回日本疲労学会総会・学術集会
  • Place of Presentation: グランフロント大阪内コングレコンベンションセンター（大阪府・大阪市）
  • Year and Date: 2015-05-30
• [Presentation] 精神疲労の評価に関わる神経メカニズムの脳磁図研究 (2015)
  • Author(s): 石井聡、田中雅彰、山野恵美、渡辺恭良
  • Organizer: 第10回日本疲労学会総会・学術集会
  • Place of Presentation: グランフロント大阪内コングレコンベンションセンター（大阪府・大阪市）
  • Year and Date: 2015-05-30
• [Presentation] [18F]AA-7: PET imaging in patients with glioma (2015)
  • Author(s): Nozaki, S., Oshita, T., Nakatani, Y., Sasano, Y., Yamamoto, K., Hume, W.E., Wada, Y., Ishii, A., Tanaka, M., Shiomi, S., Tsuyuguchi, N., Kodama, K., Watanabe, Y.
  • Organizer: 2015 ASCO Annual Meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2015-05-29
  • Int'l Joint Research
• [Presentation] 脳磁図による疲労の神経メカニズムの研究 (2015)
  • Author(s): 石井聡、田中雅彰、山野恵美、渡辺恭良
  • Organizer: 第11回日本疲労学会総会・学術集会
  • Place of Presentation: 山口県総合保健会館（山口県山口市）
  • Year and Date: 2015-05-15
  • Invited
• [Presentation] 疲労と自律神経機能・睡眠・リズム障害 (2015)
  • Author(s): 田中雅彰、石井聡、山野恵美、渡辺恭良
  • Organizer: 第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会合同大会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県・神戸市）
  • Year and Date: 2015-03-23
• [Presentation] 疲労の脳科学 (2015)
  • Author(s): 石井聡、田中雅彰、山野恵美、渡辺恭良
  • Organizer: 第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会合同大会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県・神戸市）
  • Year and Date: 2015-03-23
• [Remarks] 大阪市立大学大学院医学研究科システム神経科学
  • URL: http://www.med.osaka-cu.ac.jp/physiol/