Neural mechanism of cost-benefit based controlling motivation
| Project/Area Number |
26282221
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic / Social brain science
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
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Principal Investigator |
Minamimoto Takafumi 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 脳機能イメージング研究部, チームリーダー(定常) (50506813)
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| Co-Investigator(Renkei-kenkyūsha) |
HORI Yukiko 量子科学技術研究開発機構, 放射線医学総合研究所・脳機能イメージング研究部, 研究員 (30433246)
NAGAI Yuji 量子科学技術研究開発機構, 放射線医学総合研究所・脳機能イメージング研究部, 研究員 (20415409)
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| Research Collaborator |
KIKUCHI Erika
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | 意思決定 / サル / 遅延報酬割引 / DREADDs / 脳・神経 / 認知科学 / 神経科学 / 脳神経疾患 / 意欲 / DREADD / ドーパミン / コスト |
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| Outline of Final Research Achievements |
In this research we obtained three findings: 1) the dorsal caudate that receives innervation from the dorsolateral prefrontal cortex, is involved in controlling motivation based on temporal-discounting; 2) the rostromedial caudate that receives innervation mainly from the anterior cingulate cortex and orbitofrontal cortex, is involved in controlling motivation based on reward value; 3) the nucleus accumbens, especially its anterior portion, is involved in controlling motivation based on cost-benefit balance.
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Report
(5 results)
Research Products
(19 results)
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[Journal Article] PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation.2016
Author(s)
Nagai Y, Kikuchi E, Lerchner W, Inoue Ki, Ji B, Eldridge MA, Kaneko H, Kimura Y, Oh-Nishi A, Hori Y, Kato Y, Hirabayashi T, Fujimoto A, Kumata K, Zhang MR, Aoki I, SuharaT, Higuchi M, Takada M, Richmond BJ, Minamimoto T.
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Journal Title
Nature Communications
Volume: 7
Issue: 1
Pages: 13605-13605
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] DREADD-expressing neurons in living brain and their application to implantation of iPSC-derived neuroprogenitors.2016
Author(s)
Ji B, Kaneko H, Minamimoto T, Inoue H, Takeuchi H, Kumata K, Zhang MR, Aoki I, Seki C, Ono M, Tokunaga M, Tsukamoto S, Tanabe K, Shin RM, Minamihisamatsu T, Kito S, Richmond BJ, Suhara T, Higuchi M.
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Journal Title
J. Neuroscience
Volume: 36
Issue: 45
Pages: 11544-11558
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] In vivo PET imaging of the behaviorally active designer receptor in macaque monkeys.2014
Author(s)
4)Nagai Y, Kikuchi E, Lerchner W, Inoue K, Oh-Nishi A, Kaneko H, Kato Y, Hori Y, Ji B, Kumata K, Zhang MR, Aoki I, Suhara T, Takada M, Higuchi M, Richmond BJ, Minamimoto T.
Organizer
Society for Neuroscience
Place of Presentation
Washington DC
Year and Date
2014-11-15 – 2014-11-19
Related Report
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[Presentation] In vivo PET imaging of the behaviorally active designer receptor in macaques2014
Author(s)
1)Nagai Y, Kikuchi E, Lerchner W, Inoue K, Oh-Nishi A, Kaneko H, Kato Y, Hori Y, Ji B, Kumata K, Zhang MR, Aoki I, Suhara T, Takada M, Higuchi M, Richmond BJ, Minamimoto T.
Organizer
Neuro2014
Place of Presentation
横浜
Year and Date
2014-09-11 – 2014-09-13
Related Report
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