Neural mechanism of cost-benefit based controlling motivation

• Project/Area Number: 26282221
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Basic / Social brain science
• Research Institution: National Institutes for Quantum and Radiological Science and Technology
• Principal Investigator: Minamimoto Takafumi 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 脳機能イメージング研究部, チームリーダー(定常) (50506813)
• Co-Investigator(Renkei-kenkyūsha): HORI Yukiko 量子科学技術研究開発機構, 放射線医学総合研究所・脳機能イメージング研究部, 研究員 (30433246) ; NAGAI Yuji 量子科学技術研究開発機構, 放射線医学総合研究所・脳機能イメージング研究部, 研究員 (20415409)
• Research Collaborator: KIKUCHI Erika
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000); Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: 意思決定 / サル / 遅延報酬割引 / DREADDs / 脳・神経 / 認知科学 / 神経科学 / 脳神経疾患 / 意欲 / DREADD / ドーパミン / コスト

Outline of Final Research Achievements

In this research we obtained three findings: 1) the dorsal caudate that receives innervation from the dorsolateral prefrontal cortex, is involved in controlling motivation based on temporal-discounting; 2) the rostromedial caudate that receives innervation mainly from the anterior cingulate cortex and orbitofrontal cortex, is involved in controlling motivation based on reward value; 3) the nucleus accumbens, especially its anterior portion, is involved in controlling motivation based on cost-benefit balance.

Research Products

• [Int'l Joint Research] National Institute of Health(米国)
• [Journal Article] Roles of centromedian parafascicular nuclei of thalamus and cholinergic interneurons in the dorsal striatum in associative learning of environmental events. (2017)
  • Author(s): Yamanaka K, Hori Y, Minamimoto T, Yamada H, Matsumoto N, Enomoto K, Aosaki T, Graybiel AM, Kimura M.
  • Journal Title: J Neural Transm (Vienna). Volume: 21 Issue: 3 Pages: 1-13
  • DOI: 10.1007/s00702-017-1713-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation. (2016)
  • Author(s): Nagai Y, Kikuchi E, Lerchner W, Inoue Ki, Ji B, Eldridge MA, Kaneko H, Kimura Y, Oh-Nishi A, Hori Y, Kato Y, Hirabayashi T, Fujimoto A, Kumata K, Zhang MR, Aoki I, SuharaT, Higuchi M, Takada M, Richmond BJ, Minamimoto T.
  • Journal Title: Nature Communications Volume: 7 Issue: 1 Pages: 13605-13605
  • DOI: 10.1038/ncomms13605
  • NAID: 120005898960
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] DREADD-expressing neurons in living brain and their application to implantation of iPSC-derived neuroprogenitors. (2016)
  • Author(s): Ji B, Kaneko H, Minamimoto T, Inoue H, Takeuchi H, Kumata K, Zhang MR, Aoki I, Seki C, Ono M, Tokunaga M, Tsukamoto S, Tanabe K, Shin RM, Minamihisamatsu T, Kito S, Richmond BJ, Suhara T, Higuchi M.
  • Journal Title: J. Neuroscience Volume: 36 Issue: 45 Pages: 11544-11558
  • DOI: 10.1523/jneurosci.1279-16.2016
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] PET imaging-guided chemogenetic manipulation of reward-related circuits in monkeys. (2017)
  • Author(s): Takafumi Minamimoto
  • Organizer: Advances in Brain Neuromodulation
  • Int'l Joint Research / Invited
• [Presentation] Neural and molecular mechanisms underlying loss of motivation in monkeys. (2017)
  • Author(s): Takafumi Minamimoto
  • Organizer: 第４０回日本神経科学大会
  • Invited
• [Presentation] PET imaging-guided chemogenetic modification of reward-related circuits in monkeys. (2017)
  • Author(s): Takafumi Minamimoto
  • Organizer: BRAIN2017
  • Int'l Joint Research / Invited
• [Presentation] 8.Predicted reward value in the rostromedial caudate and the ventral pallidum for goal-directed action in monkeys. (2017)
  • Author(s): Fujimoto A, Hori Y, Nagai Y, McCairn KW, Hirabayashi T, Kikuchi E, Takada M, Suhara T, Minamimoto T
  • Organizer: 第４０回日本神経科学大会
• [Presentation] 3.Encoding expected reward value for formulating goal-directed decision in the rostro-medial caudate and the ventral pallidum. (2017)
  • Author(s): Fujimoto A, Hori Y, Nagai Y, McCairn KW, Hirabayashi T, Kikuchi E, Takada M, Suhara T, Minamimoto T
  • Organizer: Society for Neuroscience
  • Int'l Joint Research
• [Presentation] 化学遺伝学イメージングによるサル脳科学研究の展開 (2017)
  • Author(s): 南本敬史
  • Organizer: 平成28年度京都大学霊長類研究所共同利用研究会
  • Place of Presentation: 霊長類研究所, 犬山
  • Invited
• [Presentation] 動機付け制御とその障害におけるドーパミンの役割 (2016)
  • Author(s): 南本敬史
  • Organizer: 日本大脳基底核研究会
  • Place of Presentation: 秋田温泉, 秋田
  • Year and Date: 2016-07-23
  • Invited
• [Presentation] PET imaging-guided chemogenetic manipulation of primate neural circuits (2016)
  • Author(s): Takafumi Minamimoto
  • Organizer: NHP Chemogenetics workshop, NIH
  • Place of Presentation: Bethesda, USA
  • Int'l Joint Research / Invited
• [Presentation] The role of dopamine and serotonin in value-based decision-making in normal and disease state. (2015)
  • Author(s): Takafumi Minamimoto
  • Organizer: Symposium on Prediction and Decision Making 2015.
  • Place of Presentation: 東京大学
  • Year and Date: 2015-10-31
  • Int'l Joint Research / Invited
• [Presentation] 1.Region-specific effects of bilateral inactivation of limbic striatum on reward-related behavior in monkeys. (2015)
  • Author(s): Kikuchi E, Hori Y, Nagai Y, Suhara T, Samejima K, Minamimoto T.
  • Organizer: 日本神経科学学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2015-08-28
• [Presentation] In vivo PET imaging of the behaviorally active designer receptor in macaque monkeys. (2014)
  • Author(s): 4)Nagai Y, Kikuchi E, Lerchner W, Inoue K, Oh-Nishi A, Kaneko H, Kato Y, Hori Y, Ji B, Kumata K, Zhang MR, Aoki I, Suhara T, Takada M, Higuchi M, Richmond BJ, Minamimoto T.
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington DC
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] In vivo PET imaging of the behaviorally active designer receptor in macaques (2014)
  • Author(s): 1)Nagai Y, Kikuchi E, Lerchner W, Inoue K, Oh-Nishi A, Kaneko H, Kato Y, Hori Y, Ji B, Kumata K, Zhang MR, Aoki I, Suhara T, Takada M, Higuchi M, Richmond BJ, Minamimoto T.
  • Organizer: Neuro2014
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-11 – 2014-09-13
• [Remarks] 放射線医学総合研究所 脳機能イメージング研究部 システム神経回路研究チーム
  • URL: http://www.nirs.qst.go.jp/seika/brain/team/system_09.html
• [Remarks] システム神経回路研究チーム
  • URL: http://www.nirs.qst.go.jp/seika/brain/team/system_09.html
• [Remarks] 放射線医学総合研究所 分子神経イメージング研究プログラム 神経情報チームWeb
  • URL: http://www.nirs.go.jp/research/division/mic/group/t_system-bunshi.html