Formation of Functional Molecules Based on Functional Alkyllithium Generations
| Project/Area Number |
26288049
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Keywords | 炭素アニオン / フロー合成 / マイクロリアクター / アルキルリチウム / 不安定活性種 / フローマイクロリアクター / 保護基フリー合成 / 有機リチウム反応 |
|---|
| Outline of Final Research Achievements |
Flow microreactors provide a powerful method for novel transformations via functional alkyllithiums that cannot be achieved using a conventional macro batch reactor. Various functional alkyllithiums involving electrophilic functional groups was successfully generated and used for subsequent reactions. The series of reactions with high reactivity could be achieved by extremely accurate control over residence time in a controlled and selective manner.
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| Academic Significance and Societal Importance of the Research Achievements |
フローマイクロリアクターの特長を活かし、「活性種制御法」や「反応の選択性制御法」を深化させ、sp3炭素アニオン活性種の高次制御を基軸とする機能性物質創製法のための本研究成果は、従来のフラスコでの合成化学の枠を超えて、今までにない分子変換プロセスや機能性物質創製法を提供するものである。
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Report
(6 results)
Research Products
(91 results)
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[Journal Article] Feasibility Study on Continuous Flow Controlled/Living Anionic Polymerization Processes2016
Author(s)
Nagaki, A.*; Nakahara, Y.; Furusawa, M.; Sawaki, T.; Yamamoto, T.; Toukairin, H.; Tadokoro, S.; Shimazaki, T.; Ito, T.; Otake, M.; Arai, H.; Higashida, N.; Takahashi, Y.; Moriwaki, Y.; Tsuchihashi, Y.; Hirose, K.; Yoshida, J.*
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Journal Title
Org. Process Res. Dev.
Volume: 20
Issue: 7
Pages: 1377-1382
DOI
Related Report
Peer Reviewed
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[Journal Article] マイクロ流路を利用した空間的反応集積化2016
Author(s)
Jun-ichi Yoshida, Hejin Kim, Aiichiro Nagaki
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Journal Title
Chemistry & chemical industry
Volume: 69
Pages: 117-119
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Generation and Reactions of unstable perfluoroalkyl-substituted organolithiums Using Flow Microreactors2014
Author(s)
A. Nagaki, S. Tokuoka, S. Yamada, Y. Tomida, K. Oshiro, H. Amii, T. Ichitsuka, J. Ichikawa, J. Yoshida
Organizer
The 13nd International Conference on Microreaction Technology,
Place of Presentation
Budapest, Hungary
Year and Date
2014-06-24
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