Formation of Functional Molecules Based on Functional Alkyllithium Generations

• Project/Area Number: 26288049
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Synthetic chemistry
• Research Institution: Kyoto University
• Principal Investigator: NAGAKI AIICHIRO 京都大学, 工学研究科, 准教授 (80452275)
• Project Period (FY): 2014-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000); Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
• Keywords: 炭素アニオン / フロー合成 / マイクロリアクター / アルキルリチウム / 不安定活性種 / フローマイクロリアクター / 保護基フリー合成 / 有機リチウム反応

Outline of Final Research Achievements

Flow microreactors provide a powerful method for novel transformations via functional alkyllithiums that cannot be achieved using a conventional macro batch reactor. Various functional alkyllithiums involving electrophilic functional groups was successfully generated and used for subsequent reactions. The series of reactions with high reactivity could be achieved by extremely accurate control over residence time in a controlled and selective manner.

Academic Significance and Societal Importance of the Research Achievements

フローマイクロリアクターの特長を活かし、「活性種制御法」や「反応の選択性制御法」を深化させ、sp3炭素アニオン活性種の高次制御を基軸とする機能性物質創製法のための本研究成果は、従来のフラスコでの合成化学の枠を超えて、今までにない分子変換プロセスや機能性物質創製法を提供するものである。

Research Products

• [Journal Article] フローマイクロリアクターを用いた有機合成反応の選択性制御 (2019)
  • Author(s): Nagaki, A.*; Takumi, M.
  • Journal Title: 「フローマイクロ合成の最新動向」ファインケミカル, Volume: 47 Pages: 13-23
• [Journal Article] フローマイクロリアクターを用いた高分子合成反応とその連続運転 (2019)
  • Author(s): Nagaki, A.*; Nakahara, Y.; Endo, Y.
  • Journal Title: 「化学プロセスの設計とスケールアップ、連続化技術」技術情報協会, Pages: 515-526
• [Journal Article] フローマイクロリアクターを用いた有機合成反応の選択性制御 (2019)
  • Author(s): Takahashi, Y.; Nagaki, A.*
  • Journal Title: 「化学プロセスの設計とスケールアップ、連続化技術」技術情報協会, Pages: 477-493
• [Journal Article] Molecular Weight Distribution of Polymers Produced by Anionic Polymerization Enables Mixability Evaluation (2019)
  • Author(s): Endo Yuta、Furusawa Mai、Shimazaki Toshiya、Takahashi Yusuke、Nakahara Yuichi、Nagaki Aiichiro
  • Journal Title: Organic Process Research & Development Volume: 23 Issue: 4 Pages: 635-640
  • DOI: 10.1021/acs.oprd.8b00403
  • Peer Reviewed / Open Access
• [Journal Article] Modeling and Design of a Flow-Microreactor-Based Process for Synthesizing Ionic Liquids (2019)
  • Author(s): Nakahara Yuichi、Metten Bert、Tonomura Osamu、Nagaki Aiichiro、Hasebe Shinji、Yoshida Jun-ichi
  • Journal Title: Organic Process Research & Development Volume: 23 Issue: 4 Pages: 641-647
  • DOI: 10.1021/acs.oprd.8b00436
  • Peer Reviewed / Open Access
• [Journal Article] マイクロリアクターの研究開発状況とその展望 (2019)
  • Author(s): Takumi, M.; Nagaki, A.*
  • Journal Title: 「化学装置」工業通信, Volume: 61 Pages: 17-22
• [Journal Article] Synthesis of Functionalized Ketones from Acid Chlorides and Organolithiums by Extremely Fast Micromixing (2019)
  • Author(s): Nagaki Aiichiro、Sasatsuki Kengo、Ishiuchi Satoshi、Miuchi Nobuyuki、Takumi Masahiro、Yoshida Jun‐ichi
  • Journal Title: Chemistry ? A European Journal Volume: 25 Issue: 19 Pages: 4946-4950
  • DOI: 10.1002/chem.201900743
  • Peer Reviewed / Open Access
• [Journal Article] 1.Alkyllithiums Bearing Electrophilic Functional Groups: A Flash Chemistry Approach. (2019)
  • Author(s): Nagaki, A.; Yamashita, H.; Hirose, K.; Tsuchihashi, Y.; Yoshida, J.
  • Journal Title: Angew. Chem. Int. Ed. Volume: 58 Issue: 12 Pages: 40274030-40274030
  • DOI: 10.1002/anie.201814088
  • Peer Reviewed / Open Access
• [Journal Article] Suzuki-Miyaura Coupling Using Monolithic Pd Reactors and Scaling-Up by Series Connection of the Reactors (2019)
  • Author(s): Nagaki Aiichiro、Hirose Katsuyuki、Moriwaki Yuya、Takumi Masahiro、Takahashi Yusuke、Mitamura Koji、Matsukawa Kimihiro、Ishizuka Norio、Yoshida Jun-ichi
  • Journal Title: Catalysts Volume: 9 Issue: 3 Pages: 300-300
  • DOI: 10.3390/catal9030300
  • Peer Reviewed / Open Access
• [Journal Article] Blockage Detection and Diagnosis of Externally Parallelized Monolithic Microreactors (2019)
  • Author(s): Osamu Tonomura, Satoshi Taniguchi, Kazuki Nishi, Aiichiro Nagaki, Jun-ichi Yoshida, Katsuyuki Hirose, Norio Ishizuka and Shinji Hasebe
  • Journal Title: Catalysts Volume: 9 Issue: 4 Pages: 308-319
  • DOI: 10.3390/catal9040308
  • Peer Reviewed / Open Access
• [Journal Article] Annulative Synthesis of Thiazoles and Oxazoles from Alkenyl Sulfoxides and Nitriles via Additive Pummerer Reaction (2019)
  • Author(s): Hori Mitsuki、Nogi Keisuke、Nagaki Aiichiro、Yorimitsu Hideki
  • Journal Title: Asian Journal of Organic Chemistry Volume: 8 Issue: 7 Pages: 1084-1087
  • DOI: 10.1002/ajoc.201900169
  • NAID: 120006709414
  • Peer Reviewed / Open Access
• [Journal Article] Fast Micromixing Enables Selective Reactions with One of Several Same Functional Groups. (2018)
  • Author(s): Nagaki, A.; Yamashita, H.; Ishiuchi, S.; Takahashi, Y.; Imai, K.; Toshinari, K; Furusawa, M.; Yoshida, J.
  • Journal Title: Chem. Lett Volume: 47 Issue: 1 Pages: 71-73
  • DOI: 10.1246/cl.170899
  • NAID: 130006302083
  • Peer Reviewed / Open Access
• [Journal Article] Flash Generation and Borylation of 1-(trifluoromethyl)vinyllithium toward Synthesis of α-(trifluoromethyl)styrenes. (2018)
  • Author(s): Fujita, T.; Konno, N.; Watabe, Y.; Ichitsuka, T.; Nagaki, A.; Yoshida, J.; Ichikawa, J.
  • Journal Title: J. Fluorine Chem. Volume: 207 Pages: 72-76
  • DOI: 10.1016/j.jfluchem.2018.01.004
  • NAID: 120007134197
  • Peer Reviewed / Open Access
• [Journal Article] Transmission of Point Chirality to Axial Chirality for Strong Circular Dichroism in Triarylmethylium-o,o-dimers (2018)
  • Author(s): Suzuki Takanori、Ishigaki Yusuke、Iwai Tomohiro、Hayashi Yuki、Nagaki Aiichiro、Katoono Ryo、Fujiwara Kenshu、Yoshida Jun-ichi
  • Journal Title: Synlett Volume: 29 Issue: 16 Pages: 2147-2154
  • DOI: 10.1055/s-0037-1610190
  • Peer Reviewed
• [Journal Article] Efficient Preparation of Cyclic α-Alkylidene β-Oxo Imides by Using a Flow Microreactor System (2018)
  • Author(s): Komuro, K.; Nagaki, A.; Shimoda, H.; Uwamori, M.; Yoshida, J.-i.; Nakada, M.
  • Journal Title: Synlett Volume: 29 Issue: 15 Pages: 1989-1994
  • DOI: 10.1055/s-0037-1610228
  • Peer Reviewed
• [Journal Article] "Impossible" Chemistries Based on Flow and Micro. (2017)
  • Author(s): Yoshida, J.; Kim, H.; Nagaki, A.
  • Journal Title: J. Flow Chem Volume: 7 Issue: 3-4 Pages: 60-64
  • DOI: 10.1556/1846.2017.00017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Micromixing Enables Chemoselective Reactions of Difunctional Electrophiles with Functional Aryllithiums. (2017)
  • Author(s): Nagaki, A.; Ishiuchi, S.; Imai, K.; Sasatsuki, K.; Nakahara, Y.; Yoshida, J.
  • Journal Title: React. Chem. Eng. Volume: 2 Issue: 6 Pages: 862-870
  • DOI: 10.1039/c7re00142h
  • Peer Reviewed / Open Access
• [Journal Article] Generation of hazardous methyl azide and its application to synthesis of a key-intermediate of picarbutrazox, a new potent pesticide in flow (2017)
  • Author(s): Ichinari Daisuke、Nagaki Aiichiro、Yoshida Jun-ichi
  • Journal Title: Bioorganic & Medicinal Chemistry Volume: 25 Issue: 23 Pages: 6224-6228
  • DOI: 10.1016/j.bmc.2017.07.005
  • Peer Reviewed / Open Access
• [Journal Article] Flow microreactor synthesis of 2,2-disubstituted oxetanes via 2-phenyloxetan-2-yl lithium (2016)
  • Author(s): Degennaro, L.; Nagaki, A.; Moriwaki, Y.; Romanazzi, G.; Dell’Anna, M. M.; Yoshida, J.; Luisi, R
  • Journal Title: Flow microreactor synthesis of 2,2-disubs Open Chem. Volume: 14 Issue: 1 Pages: 377-382
  • DOI: 10.1515/chem-2016-0041
  • NAID: 120006305900
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] マイクロ流路を利用した空間的反応集積化 (2016)
  • Author(s): Yoshida, J.*; Kim, H.; Nagaki, A.
  • Journal Title: 化学と工業 Volume: 69 Pages: 117-119
  • Peer Reviewed
• [Journal Article] Flash cationic polymerization followed by bis-end-functionalization. A new approach to linear-dendritic hybrid polymers. (2016)
  • Author(s): Tani, Y.; Takumi, M.; Moronaga, S.; Nagaki, A.; Yoshida, J.-i.
  • Journal Title: European Polymer Journal Volume: 79 Pages: 227-233
  • DOI: 10.1016/j.eurpolymj.2016.02.021
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Design of a Numbering-up System of Monolithic Microreactors and Its Application to Synthesis of a Key Intermediate of Valsaltan (2016)
  • Author(s): Aiichiro Nagaki, Katsuyuki Hirose, Osamu Tonomura, Satoshi Taniguchi, Toshiki Taga, Shinji Hasebe, Norio Ishizuka, and Jun-ichi Yoshida
  • Journal Title: Org. Process Res. Dev. Volume: 20 Issue: 3 Pages: 687-691
  • DOI: 10.1021/acs.oprd.5b00414
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Generation and Reaction of Carbamoyl Anions in Flow: Applications in the Three-Component Synthesis of Functionalized -Ketoamides (2016)
  • Author(s): Aiichiro Nagaki, Yusuke Takahashi, and Jun-ichi Yoshida
  • Journal Title: Angew. Chem., Int. Ed. Volume: 55 Issue: 17 Pages: 5327-5331
  • DOI: 10.1002/anie.201601386
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Integration of borylation of aryllithiums and Suzuki–Miyaura coupling using monolithic Pd catalyst (2016)
  • Author(s): Aiichiro Nagaki, Katsuyuki Hirose, Yuya Moriwaki, Koji Mitamura, Kimihiro Matsukawa, Norio Ishizuka, Jun-ichi Yoshida, J.
  • Journal Title: Catal. Sci. Tech Volume: in press Issue: 13 Pages: 0-0
  • DOI: 10.1039/c5cy02098k
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Feasibility Study on Continuous Flow Controlled/Living Anionic Polymerization Processes (2016)
  • Author(s): Nagaki, A.*; Nakahara, Y.; Furusawa, M.; Sawaki, T.; Yamamoto, T.; Toukairin, H.; Tadokoro, S.; Shimazaki, T.; Ito, T.; Otake, M.; Arai, H.; Higashida, N.; Takahashi, Y.; Moriwaki, Y.; Tsuchihashi, Y.; Hirose, K.; Yoshida, J.*
  • Journal Title: Org. Process Res. Dev. Volume: 20 Issue: 7 Pages: 1377-1382
  • DOI: 10.1021/acs.oprd.6b00158
  • Peer Reviewed
• [Journal Article] Switching Between Intermolecular and Intramolecular Reactions Using Flow Microreactors. Lithiation of 2-Bromo-2'-Silylbiphenyls (2016)
  • Author(s): Nagaki, A.*; Kim, S.; Miuchi, N.; Yamashita, H.; Hirose, K.; Yoshida, J.*
  • Journal Title: Org. Chem. Front. Volume: 3 Issue: 10 Pages: 1250-1253
  • DOI: 10.1039/c6qo00257a
  • Peer Reviewed
• [Journal Article] Flow Microreactor Polymerization (2016)
  • Author(s): Nagaki, A.*
  • Journal Title: Chemical Engineering
• [Journal Article] マイクロ流路を利用した空間的反応集積化 (2016)
  • Author(s): Jun-ichi Yoshida, Hejin Kim, Aiichiro Nagaki
  • Journal Title: Chemistry & chemical industry Volume: 69 Pages: 117-119
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Polymerization of Vinyl Ethers Initiated by Dendritic Cations Using Flow Microreactors (2015)
  • Author(s): Aiichiro Nagaki, Masahiro Takumi, Yosuke Tani, and Jun-ichi Yoshida
  • Journal Title: Tetrahedron Volume: 71 Issue: 35 Pages: 5973-5978
  • DOI: 10.1016/j.tet.2015.05.096
  • NAID: 120005674615
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Organolithiums Bearing Aldehyde Carbonyl Groups. A Flash Chemistry Approach (2015)
  • Author(s): Aiichiro Nagaki, Yuta Tsuchihashi, Suguru Haraki and Jun-ichi Yoshida
  • Journal Title: Org. Biomol. Chem Volume: 13 Issue: 26 Pages: 7140-7145
  • DOI: 10.1039/c5ob00958h
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Reaction Integration (2015)
  • Author(s): Nagaki, A.
  • Journal Title: J. Syn. Org. Chem., Jpn. Volume: -
  • Peer Reviewed
• [Journal Article] .Organic Synthesis Using Flow Microreactors (2015)
  • Author(s): Nagaki, A.
  • Journal Title: J. Syn. Org. Chem., Jpn. Volume: -
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Fast Micromixing and Flow Synthesis (2015)
  • Author(s): Nagaki, A.; Yoshida, J.
  • Journal Title: NAGARE Volume: 34 Pages: 3-9
  • NAID: 110009917925
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] フラッシュケミストリー フラスコではできない合成化学をめざして (2015)
  • Author(s): Yoshida, J.; Nagaki, A.; Kim, H.; Ichinari, D.
  • Journal Title: Kagaku Volume: 70 Pages: 19-24
  • Acknowledgement Compliant
• [Journal Article] Remarkable Chemoselectivity by Flash Chemistry. Reactions of Difunctional Electrophiles with Functionalized Aryllithiums (2015)
  • Author(s): Nagaki, A.; Imai, K.; Ishiuchi, S.; Yoshida, J.
  • Journal Title: Angew. Chem., Int. Ed. Volume: 54 Issue: 6 Pages: 1914-1918
  • DOI: 10.1002/anie.201410717
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Flash Chemistry Using Trichlorovinyllithium. Switching the Reaction Pathways by High-Resolution Reaction Time Control (2015)
  • Author(s): Nagaki, A.; Takahashi, Y.; Henseler, A.; Matsuo, C.; Yoshida, J.
  • Journal Title: Chem. Lett. Volume: 44 Issue: 2 Pages: 214-216
  • DOI: 10.1246/cl.140980
  • NAID: 130004868340
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Three-Component Coupling Based on Flash Chemistry. Carbolithiation of Benzyne with Functionalized Aryllithiums Followed by Reactions with Electrophiles (2014)
  • Author(s): Nagaki, A.; Ichinari, D.; Yoshida, J.
  • Journal Title: J. Am. Chem. Soc. Volume: 136 Issue: 35 Pages: 12245-12248
  • DOI: 10.1021/ja5071762
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Flow Microreactor Synthesis of Fluorine-Containing Block Copolymers (2014)
  • Author(s): Nagaki, A.; Akahori, K.; Takahashi, Y.; Yoshida, J.
  • Journal Title: J. Flow Chem. Volume: 4 Issue: 4 Pages: 168-172
  • DOI: 10.1556/jfc-d-14-00017
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Flash Generation of α-(Trifluoromethyl)vinyllithium and Application to Continuous Flow Three-Component Synthesis of -Trifluoromethylamides (2014)
  • Author(s): Nagaki, A.; Tokuoka, S.; Yoshida, J.
  • Journal Title: Chem. Commun. Volume: 50 Issue: 95 Pages: 15079-15081
  • DOI: 10.1039/c4cc06709f
  • Peer Reviewed
• [Journal Article] Extremely Fast Gas/Liquid Reactions in Flow Microreactors: Carboxylation of Short-Lived Organolithiums (2014)
  • Author(s): Nagaki, A.; Tokuoka, S.; Yoshida, J.
  • Journal Title: Chem. Eur. J. Volume: 20 Issue: 26 Pages: 7931-7934
  • DOI: 10.1002/chem.201402520
  • NAID: 120005646496
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] TBA (2019)
  • Author(s): 永木 愛一郎
  • Organizer: 2018 年度マイクロコンソーシアム講演会
  • Invited
• [Presentation] 超高速合成化学 ?マイクロリアクターの最前線? (2019)
  • Author(s): 永木 愛一郎
  • Organizer: 京大テックフォーラム
  • Invited
• [Presentation] マイクロリアクターを用いた超高速合成化学 (2019)
  • Author(s): 永木 愛一郎
  • Organizer: 第10回マイクロリアクターシステム研究所シンポジウム
  • Invited
• [Presentation] フローマイクロリアクターを用いた精密合成 (2019)
  • Author(s): 永木 愛一郎
  • Organizer: 情報機構
  • Invited
• [Presentation] Organolithium Chemistry Using Flow Microreactors (2018)
  • Author(s): Aiichiro Nagaki
  • Organizer: International Pharma Conference and Expo
  • Int'l Joint Research / Invited
• [Presentation] フローマイクロリアクターを用いた超高速反応による精密合成 (2018)
  • Author(s): 永木 愛一郎
  • Organizer: 有機合成化学講習会
  • Invited
• [Presentation] フローマイクロリアクターを用いた精密合成 (2018)
  • Author(s): 永木 愛一郎
  • Organizer: 情報機構
  • Invited
• [Presentation] Organolithium Chemistry Using Flow Microreactors (2018)
  • Author(s): Aiichiro Nagaki
  • Organizer: 16th Annual Congress of International Drug Discovery Science and Technology
  • Int'l Joint Research / Invited
• [Presentation] Organolithium Chemistry Using Flow Microreactors (2018)
  • Author(s): Aiichiro Nagaki
  • Organizer: The 4th Int'l Conference on Organic Chemistry
  • Int'l Joint Research / Invited
• [Presentation] Organolithium Chemistry Using Flow Microreactors and Its Applications to Palladium Catalyzed Crosscoupling (2018)
  • Author(s): Aiichiro Nagaki
  • Organizer: 3rd International Conference on Catalysis and Chemical Engineering
  • Int'l Joint Research / Invited
• [Presentation] 超高速合成化学 ～マイクロリアクターの最前線～ (2018)
  • Author(s): 永木愛一郎
  • Organizer: 京大テックフォーラム
  • Invited
• [Presentation] フローマイクロリアクターを用いた精密合成 (2018)
  • Author(s): 永木愛一郎
  • Organizer: 技術情報協会
  • Invited
• [Presentation] Organolithium Chemistry Using Flow Microreactors and Its Applications to Palladium Catalyzed Crosscoupling (2017)
  • Author(s): aiichiro nagaki
  • Organizer: International Conference on Catalysis and Chemical Engineering
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2017-02-22
  • Int'l Joint Research / Invited
• [Presentation] マイクロリアクターの基本知識と効果的な使い方 (2017)
  • Author(s): 永木愛一郎
  • Organizer: 情報機構
  • Invited
• [Presentation] Organolithium Chemistry Using Flow Microreactors. (2017)
  • Author(s): Nagaki, A.
  • Organizer: The 11th International Symposium on Integrated Synthesis (ISONIS-11)
  • Int'l Joint Research / Invited
• [Presentation] Organolithium Chemistry Using Flow Microreactors. (2017)
  • Author(s): Nagaki, A.
  • Organizer: 6th Gratama Workshop in Chemical Sciences and Innovations for a Sustainable Society
  • Int'l Joint Research / Invited
• [Presentation] Organolithium Chemistry Using Flow Microreactors. (2017)
  • Author(s): Nagaki, A.
  • Organizer: 2017 University of Bari
  • Int'l Joint Research / Invited
• [Presentation] 国際シンポ「ICAMS-1」のハイライト (2017)
  • Author(s): 永木愛一郎
  • Organizer: フローマイクロ合成研究会（第76回研究会）
  • Invited
• [Presentation] フロー技術の革新による超高速合成 (2017)
  • Author(s): 永木愛一郎
  • Organizer: 第7回CSJ化学フェスタ2017
  • Invited
• [Presentation] イオン反応の反応集積化 (2017)
  • Author(s): 永木愛一郎
  • Organizer: 新学術領域研究「反応集積化が導く中分子戦略：高次生物機能分子の創製」平成29 年度第4回成果報告会
  • Invited
• [Presentation] Flow Microreactors Enables Green Chemistry Approach for Organolithium Chemistry. (2017)
  • Author(s): Nagaki, A.
  • Organizer: 5th International Conference on Green Chemistry and Technology
  • Int'l Joint Research / Invited
• [Presentation] Anionic Polymerizations Using Flow Microreactors (2016)
  • Author(s): aiichiro nagaki
  • Organizer: Polymer Chemistry 2016 International Conference,
  • Place of Presentation: Atlanta, USA
  • Year and Date: 2016-11-14
  • Int'l Joint Research / Invited
• [Presentation] Synthesis of Organofluorine Compounds Using Flow Microreactors (2016)
  • Author(s): aiichiro nagaki
  • Organizer: 2nd World Chemistry Conference,
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2016-08-08
  • Int'l Joint Research / Invited
• [Presentation] Organolithium Chemistry Using Flow Microreactors to Green Chemistry (2016)
  • Author(s): aiichiro nagaki
  • Organizer: 7th Annual Global Congress of Catalysis 2016,
  • Place of Presentation: Seoul, South Korea
  • Year and Date: 2016-06-30
  • Int'l Joint Research / Invited
• [Presentation] Remarkable Chemoselectivity by Flash Chemistry (2016)
  • Author(s): aiichiro nagaki
  • Organizer: The 12th International Symposium on Organic Reactions
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2016-04-22
  • Int'l Joint Research / Invited
• [Presentation] Organolithium Chemistry Using Flow Microreactors (2016)
  • Author(s): aiichiro nagaki
  • Organizer: International Nanotechnology Conference & Expo
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2016-04-04
  • Int'l Joint Research / Invited
• [Presentation] フローマイクロリアクターを用いたアニオン重合の連続運転 (2016)
  • Author(s): 永木愛一郎、中原祐一、古澤真維、沢木智也、山本哲也、東海林英明、田所真介、島崎寿也、伊藤 寿英、大竹正兼、荒井秀紀、東田直也、大塚啓太、高橋裕輔、森脇佑也、土橋祐太、廣瀬勝幸、吉田潤一
  • Organizer: 日本化学会第96春季年会
  • Place of Presentation: 京都
  • Year and Date: 2016-03-24
• [Presentation] フロー・マイクロ合成：均一系反応 (2016)
  • Author(s): 永木愛一郎
  • Organizer: 第一回 新学術領域研究「反応集積化が導く中分子戦略：高次生物機能分子の創製」若手シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2016-03-11
  • Invited
• [Presentation] 有機リチウム種の高次制御に基づく反応集積化 (2016)
  • Author(s): 永木愛一郎
  • Organizer: 第一回 新学術領域研究「反応集積化が導く中分子戦略：高次生物機能分子の創製」若手シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2016-03-11
  • Invited
• [Presentation] Organolithium Chemistry Using Flow Microreactors (2016)
  • Author(s): aiichiro nagaki
  • Organizer: The 2nd Annual World Congress of Smart Materials-2016
  • Place of Presentation: Havelock Road, Singapore
  • Year and Date: 2016-03-04
  • Int'l Joint Research / Invited
• [Presentation] イオン反応の反応集積化 (2016)
  • Author(s): 永木愛一郎
  • Organizer: 第一回 新学術領域研究「反応集積化が導く中分子戦略：高次生物機能分子の創製」平成27 年度第1 回成果報告会
  • Place of Presentation: 大阪
  • Year and Date: 2016-02-07
• [Presentation] Flash Chemistry Enables Chemoselective Reactions of Difunctional Electrophiles with Functionalized Aryllithiums (2015)
  • Author(s): Aiichiro Nagaki, Satoshi Ishiuchi, Keita Imai, and Jun-ichi Yoshida
  • Organizer: The 2015 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Honolulu, Hawai
  • Year and Date: 2015-12-17
  • Int'l Joint Research
• [Presentation] Organolithium Chemistry Using Flow Microreactors (2015)
  • Author(s): Aiichiro Nagaki
  • Organizer: 4th Asia-Pacific Chemical and Biological Microfluidics Conferences
  • Place of Presentation: Pharma, Vietnam
  • Year and Date: 2015-11-02
  • Int'l Joint Research / Invited
• [Presentation] Organolithium Chemistry Using Flow Microreactors to Green Chemistry (2015)
  • Author(s): Aiichiro Nagaki
  • Organizer: 2nd International Conference on Past and Present Research Systems of Green Chemistry
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-09-14
  • Int'l Joint Research / Invited
• [Presentation] フローマイクロリアクターを用いた精密カチオン重合 (2015)
  • Author(s): 永木愛一郎、宅見 正浩、谷 洋介、吉田潤一
  • Organizer: 化学工学会第47秋季大会
  • Place of Presentation: 北海道
  • Year and Date: 2015-09-09
• [Presentation] マイクロリアクターによる化学合成プロセスの革新 (2015)
  • Author(s): 永木愛一郎
  • Organizer: 京都産学公連携フォーラム2015
  • Place of Presentation: 京都パルスプラザ
  • Year and Date: 2015-01-19
  • Invited
• [Presentation] 「フローマイクロリアクターを用いた精密アニオン重合とその含フッ素ポリマー合成への応用」 (2014)
  • Author(s): 永木愛一郎、赤堀加奈、高橋裕輔、吉田潤一
  • Organizer: 化学とマイクロ・ナノシステム学会第30回研究会
  • Place of Presentation: 北海道大学フロンティア応用科学研究棟
  • Year and Date: 2014-10-02
• [Presentation] 「フローマイクロリアクターを用いた精密アニオン重合とその含フッ素ポリマー合成への応用」 (2014)
  • Author(s): 永木愛一郎、赤堀加奈、高橋裕輔、吉田潤一
  • Organizer: 第63回高分子討論会
  • Place of Presentation: 長崎大学文教キャンパス
  • Year and Date: 2014-09-18
• [Presentation] 「マイクロリアクターによる有機リチウム反応の新展開」 (2014)
  • Author(s): 永木愛一郎
  • Organizer: 第30回若手化学者のための化学道場
  • Place of Presentation: 岡山大学
  • Year and Date: 2014-08-29
  • Invited
• [Presentation] Organolithium Chemistry Using Flow Microreactors A. Nagaki, J. Yoshida 12th International Conference on Nanochannels, Microchannels, and Minichannels, (2014)
  • Author(s): A. Nagaki, J. Yoshida
  • Organizer: 12th International Conference on Nanochannels, Microchannels, and Minichannels,
  • Place of Presentation: Chicago,America
  • Year and Date: 2014-08-03
• [Presentation] Generation and Reactions of unstable perfluoroalkyl-substituted organolithiums Using Flow Microreactors (2014)
  • Author(s): A. Nagaki, S. Tokuoka, S. Yamada, Y. Tomida, K. Oshiro, H. Amii, T. Ichitsuka, J. Ichikawa, J. Yoshida
  • Organizer: The 13nd International Conference on Microreaction Technology,
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2014-06-24
• [Presentation] 「フローマイクロリアクターを用いた不安定有機リチウム種のカルボキシル化」 (2014)
  • Author(s): 永木愛一郎、高橋裕輔、吉田潤一
  • Organizer: 化学とマイクロ・ナノシステム学会第29回研究会
  • Place of Presentation: 日本女子大学 目白キャンパス
  • Year and Date: 2014-05-22
• [Book] フローマイクロ合成の実用化への展望 (2017)
  • Author(s): 永木愛一郎
  • Total Pages: 11
  • Publisher: シーエムシー出版
  • ISBN: 9784781312323
• [Book] フローマイクロ合成の実用化への展望 (2016)
  • Author(s): Kim, H.; Nagaki, A.; Yoshida, J.
  • Total Pages: 211
  • Publisher: シーエムシー出版
• [Book] Organometallic Flow Chemistry (2016)
  • Author(s): Nagaki, A.; Yoshida, J.
  • Total Pages: 38
  • Publisher: Springer Nature
• [Book] Topics in Organometallic Chemistry (2016)
  • Author(s): Nagaki, A.; Yoshida, J.
  • Publisher: Springer
• [Book] Wiley-VCH, Lithium Compounds in Organic Synthesis - From Fundamentals to Applications. (2014)
  • Author(s): Nagaki, A.; Yoshida, J.
  • Total Pages: 21
  • Publisher: Willy
• [Book] DOJIN ACADEMICシリーズ 「フロー・マイクロ合成」 (2014)
  • Author(s): Nagaki, A.
  • Total Pages: 9
  • Publisher: 化学同人
• [Remarks] 京都大学 大学院工学研究科合成・生物化学専攻 有機合成化学研究室
  • URL: http://www.sbchem.kyoto-u.ac.jp/yoshida-lab/
• [Remarks] 京都大学大学院工学研究科 合成・生物化学専攻 合成化学講座 有機合成化学研究室
  • URL: http://www.sbchem.kyoto-u.ac.jp/yoshida-lab/
• [Patent(Industrial Property Rights)] アルキルリチウム、化合物の製造方法、ポリマー、及びポリマーの製造方法 (2017)
  • Inventor(s): 永木愛一郎
  • Industrial Property Rights Holder: 永木愛一郎
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017