| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
|
|---|
| Outline of Final Research Achievements |
(1) In 19F NMR analysis of the structure of human telomeric RNA in living cells and in what manner interacts with proteins and ligand molecules (Nucleic Acids Res. 45, 5501, 2017; Nature Protocols 13, 652, 2018.) (ChemistrySelect, 2, 4170, 2017; JACS. 139, 7533, 2017; Molecules 23, 237, 2018). (2) We have discovered the antiparallel RNA quadruplex structure which was thought not to exist until now (Sci. Rep. 7, 6695, 2017; Chem. Commun. 54, 3944, 2018.). (3) We succeeded in developing multifunctional guanine derivatives for detecting G-quadruplex structure (Analyst 142, 4083, 2017; ACS Omega 2, 8843, 2017). (4) We succeeded in analyzing DNA-RNA hybrid quadruplex structure in the cell and detection of telomere DNA by utilizing the click reaction (Bioorg. Med. Chem. 135, 44191, 2014; J. Nat Sci. 2: e 237, 2016; Sci. Rep. 6, 33217, 2016.).
|
