Study of GABAergic transmission mechanism using glutamate decarboxylase knockout mice
| Project/Area Number |
26290002
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Gunma University |
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Principal Investigator |
YANAGAWA YUCHIO 群馬大学, 大学院医学系研究科, 教授 (90202366)
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| Co-Investigator(Renkei-kenkyūsha) |
KAKIZAKI TOSHIKAZU 群馬大学, 大学院医学系研究科, 助教 (50375531)
MIWA HIDEKI 群馬大学, 大学院医学系研究科, 助教 (80468488)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | GABA / GAD65 / GAD67 / ノックアウトマウス / テトラサイクリン発現システム / 神経科学 / 脳・神経 / 酵素 / 脳神経疾患 |
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| Outline of Final Research Achievements |
GABA is a major inhibitory neurotransmitter, and it is synthesized from glutamate by glutamate decarboxylase (GAD). There are two isoforms of GAD, GAD65 and GAD67. GAD67 knockout mice died at postnatal day 0 (P0), and thus they cannot be characterized after P0. We generated time-dependent GAD67 knockout mice. In addition, we generated GAD67 knockout rats, which were found alive after 3 weeks of age. These genetically engineered rodents will be a useful tool for clarifying the role of GAD67 and GABA in brain function.
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Report
(5 results)
Research Products
(35 results)
