Investigation of redirected Tax-specific T-cell immunotherapy against adult T-cell leukemia/lymphoma
| Project/Area Number |
26290058
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor therapeutics
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
諫田 淳也 自治医科大学, 医学部, 講師 (30636311)
仲宗根 秀樹 自治医科大学, 医学部, 講師 (50757903)
山崎 理絵 自治医科大学, 医学部, 助教 (80365262)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
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| Keywords | 遺伝子導入免疫細胞療法 / 腫瘍特異的免疫細胞療法 / 免疫学 / 細胞免疫療法 / 成人T細胞性白血病 / 遺伝子治療 |
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| Outline of Final Research Achievements |
Adult T-cell leukemia/lymphoma (ATL) is a hematological malignancy caused by HTLV-I infection. ATL is refractory to chemotherapy and the prognosis of patients with ATL is extremely poor. We have revealed that cytotoxic T-cells (CTLs) against Tax, a protein produced by HTLV-I, increased after allogeneic hematopoietic stem cell transplantation for ATL and found that CTLs with T-cell receptor (TCR) repertoir containing "PDR" motif exhibit strong cytotoxic activity against HTLV-I infected cells. In addition, we produced redirected Tax-specific CTL by transducing the full-length TCR alpha and beta genes of the "PDR"-containing TCR to peripheral blood mononuclear cells from healthy volunteers using retroviral vector, and showed that the redirected CTLs also had strong cytotoxic activity against HTLV-I infected cells both in vitro and in vivo (patent pending).
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Report
(4 results)
Research Products
(3 results)
