Analysis of the imprinted regions based on the entire transcriptome
| Project/Area Number |
26290063
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Genome biology
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| Research Institution | Kochi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
近藤 伸二 大学共同利用機関法人情報・システム研究機構(新領域融合研究センター及びライフサイ, 大学共同利用機関等の部局等, 准教授 (30415161)
加藤 英政 埼玉医科大学, 医学部, 准教授 (50292123)
栄徳 勝光 高知大学, 教育研究部医療学系連携医学部門, 助教 (50552733)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | ゲノム刷り込み / トランスクリプトーム / エピジェネティクス / 幹細胞 / 神経分化 / ゲノム / エピゲノム |
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| Outline of Final Research Achievements |
We attempted to identify novel neuron-specific imprinted region with the samples utilizing in vitro neuronal differentiation system and RNA-seq. We performed transcriptome analysis with those data, and identified novel imprinted regions, including the regions producing non-coding RNAs. We also performed a similar analysis with iPS cells, and identified difference from the ES cell data. We obtained the ChIP-seq data with H3K36 and TSS-seq data, and analyzed the transcriptional landscape of long non-coding RNAs.
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Report
(4 results)
Research Products
(7 results)
