The analysis of systematic gene regulation in skeletal muscle differentiation

• Project/Area Number: 26290064
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Genome biology
• Research Institution: Kyushu University
• Principal Investigator: Ohkawa Yasuyuki 九州大学, 生体防御医学研究所, 教授 (80448430)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: 骨格筋分化 / クロマチン / 転写制御 / エピゲノム / 高次クロマチン構造 / クロマチンモデリング / クロマチンリモデリング / 高次クロマチン

Outline of Final Research Achievements

The human body comprises circa 37 trillion cells of more than 200 types. These cells acquire individual functions through selective expression of genes and become part of particular tissues. The Human Genome Project ushered in methodologies toward the determination of the entire sequences on the genome and the analysis of the complete set of genes. However, the knowledge of every cell type and the exact number of genes and their positions on the genome still eludes us. To address the regulatory system to commit cell fate on chromatin, we here demonstrated to identify histone variants as the context of chromatin comprehensively. We identified 14 novel histone H3 genes and a couple of H3 genes are specifically expressed in skeletal stem/progenitor cells. KO experiments showed the requirements of each histone H3 variants for myogenesis and it's function on chromatin was evaluated by a set of epigenome profiling. The data showed that each histone variants was required for myogenesis.

Research Products

• [Int'l Joint Research] NIH(米国)
• [Journal Article] GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes. (2017)
  • Author(s): Nakayama A, Nakaoka H, Yamamoto K, Sakiyama M, Shaukat A, Toyoda Y, Okada Y, Ohkawa Y,他39名
  • Journal Title: Ann Rheum Dis. Volume: 76 Issue: 5 Pages: 869-877
  • DOI: 10.1136/annrheumdis-2016-209632
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Role of Ad4-binding protein/steroidogenic factor 1 in regulating NADPH production in adrenocortical Y-1 cells (2017)
  • Author(s): Li B, BabaT, Miyabayashi K, Sato T, Shima Y, Ichinose T, Miura D, Ohkawa Y, Suyama M, Morohashi KI
  • Journal Title: Endocrine Journal Volume: 64 Issue: 3 Pages: 315-324
  • DOI: 10.1507/endocrj.EJ16-0467
  • NAID: 130005529460
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells. (2017)
  • Author(s): Shishido Y, Baba T, Sato T, Shima Y, Miyabayashi K, Inoue M, Akiyama H, Kimura H, Kanal Y, Ishihara Y, Haraguchi S, Miyazaki A, Rozman D, Yamazaki T, Choi MH, Ohkawa Y, Suyama M, Morohashi KI
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 41912-41912
  • DOI: 10.1038/srep41912
  • NAID: 120006799381
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis. (2017)
  • Author(s): Ueda J, Harada A, Urahama T, Machida S, Maehara K, Hada M, Makino Y, Nogami J, Horikoshi N, Osakabe A, Taguchi H, Tanaka H, Tachiwana H, Yao T, Yamada M, Iwamoto T, Isotani A, Ikawa M, Tachibana T, Okada Y, Kimura H, Ohkawa Y, Kurumizaka H, Yamagata K.
  • Journal Title: Cell Rep. Volume: 18 Pages: 593-600
  • NAID: 120006957416
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Periostin Promotes Scar Formation through the Interaction between Pericytes and InfiltratingMonocytes/Macrophages after Spinal Cord Injury. (2017)
  • Author(s): Yokota K, Kobayakawa K, Saito T, Hara M, Kijima K, Ohkawa Y, Harada A, Okazaki K, Ishihara K, Yoshida S, Kudo A, Iwamoto Y, Okada S.
  • Journal Title: Am J Pathol. Volume: 187 Pages: 639-653
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Alterations in Fetal Leydig Cell Gene Expression during Fetal and Adult Development. (2016)
  • Author(s): Miyabayashi K, Shima Y, Inoue M, Sato T, Baba T, Ohkawa Y, Suyama M, Morohashi KI.
  • Journal Title: Sex Dev. Volume: -
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A One-Step Immunostaining Method to Visualize Rodent Muscle Fiber Type within a Single Specimen. (2016)
  • Author(s): Sawano S, Komiya Y, Ichitsubo R, Ohkawa Y, Nakamura M, Tatsumi R, Ikeuchi Y, Mizunoya W.
  • Journal Title: PLoS One. Volume: 11 Issue: 11 Pages: e0166080-e0166080
  • DOI: 10.1371/journal.pone.0166080
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification of Immunoglobulin Gene Sequences from a Small Read Number of mRNA-Seq Using Hybridomas. (2016)
  • Author(s): Kuniyoshi Y, Maehara K, Iwasaki T, Hayashi M, Semba Y, Fujita M, Sato Y, Kimura H, Harada A, Ohkawa Y.
  • Journal Title: PLoS One Volume: 11 Issue: 10 Pages: e0165473-e0165473
  • DOI: 10.1371/journal.pone.0165473
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] CHD8 haploinsufficiency results in autistic-like phenotypes in mice (2016)
  • Author(s): Katayama, Y., Nishiyama, M., Shoji, H., Ohkawa, Y., Kawamura, A., Sato, T., Suyama, M., Takumi, T., Miyakawa, T., Nakayama, K. I.
  • Journal Title: Nature Volume: 537 Issue: 7622 Pages: 675-679
  • DOI: 10.1038/nature19357
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] MRG15 is required for pre-mRNA splicing and spermatogenesis. (2016)
  • Author(s): Iwamori N, Tominaga K, Sato T, Riehle K, Iwamori T, Ohkawa Y, Coarfa C, Ono E, Matzuk MM.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 113 Issue: 37
  • DOI: 10.1073/pnas.1611995113
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] LATS2 Positively Regulates Polycomb Repressive Complex 2. (2016)
  • Author(s): Torigata K, Daisuke O, Mukai S, Hatanaka A, Ohka F, Motooka D, Nakamura S,Ohkawa Y, Yabuta N, Kondo Y, Nojima H.
  • Journal Title: PLoS One Volume: 11 Issue: 7 Pages: e0158562-e0158562
  • DOI: 10.1371/journal.pone.0158562
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] TLR signals posttranscriptionally regulate the cytokine trafficking mediator sortilin. (2016)
  • Author(s): Yabe-Wada T, Matsuba S, Takeda K, Sato T, Suyama M, Ohkawa Y, Takai T, Shi H, Philpott CC, Nakamura A.
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 26566-26566
  • DOI: 10.1038/srep26566
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The feasibility of in vivo imaging of infiltrating blood cells for predicting the functional prognosis after spinal cord injury. (2016)
  • Author(s): Yokota K, Saito T, Kobayakawa K, Kubota K, Hara M, Murata M, Ohkawa Y, Iwamoto Y, Okada S.
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 25673-25673
  • DOI: 10.1038/srep25673
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Histone H4 lysine 20 acetylation is associated with gene repression in human cells. (2016)
  • Author(s): Kaimori, J. Y., Maehara, K., Hayashi-Takanaka, Y., Harada, A., Fukuda, M., Yamamoto, S., Ichimaru, N., Umehara, T., Yokoyama, S., Matsuda, R., Ikura, T., Nagao, K., Obuse, C., Nozaki, N., Takahara, S., Takao, T., Ohkawa, Y., Kimura, H., and Isaka, Y.
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 24318-24318
  • DOI: 10.1038/srep24318
  • NAID: 120005770760
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Chromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing (2016)
  • Author(s): Kobayashi W., Takaku M., Machida S., Tachiwana H., Maehara K., Ohkawa Y. and Kurumizaka H
  • Journal Title: Scientific reports Volume: 6 Issue: 1 Pages: 24428-24428
  • DOI: 10.1038/srep24228
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Exploration of nucleosome positioning patterns in transcription factor function. (2016)
  • Author(s): Maehara K, Ohkawa Y.
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 19620-19620
  • DOI: 10.1038/srep19620
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Histone H3.5 forms an unstable nucleosome and accumulates around transcription start sites in human testis. (2016)
  • Author(s): Urahama T, Harada A, Maehara K, Horikoshi N, Sato K, Sato Y, Shiraishi K, Sugino N, Osakabe A, Tachiwana H, Kagawa W, Kimura H, Ohkawa Y, Kurumizaka H.
  • Journal Title: Epigenetics Chromatin Volume: 9 Issue: 1 Pages: 1-16
  • DOI: 10.1186/s13072-016-0051-y
  • Peer Reviewed / Open Access
• [Journal Article] Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes. (2016)
  • Author(s): Oka M, Mura S, Yamada K, Sangel P, Hirata S, Maehara K, Kawakami K, Tachibana T, Ohkawa Y, Kimura H, Yoneda Y
  • Journal Title: eLIFE Volume: 5
  • DOI: 10.7554/elife.09540
  • Peer Reviewed / Open Access
• [Journal Article] solation and characterization of mouse fetal Leydig progenitor cells (2016)
  • Author(s): Miki Inoue, Yuichi Shima, Kanako Miyabayashi, Tetsuya Sato, Takashi Baba, Yasuyuki Ohkawa, Haruhiko Akiyama, Mikita Suyama, Ken-ichirou Morohashi
  • Journal Title: Endocrinology Volume: 157 Issue: 3 Pages: 1222-1233
  • DOI: 10.1210/en.2015-1773
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Chd5 Regulates MuERV-L/MERVL Expression in Mouse Embryonic Stem Cells Via H3K27me3 Modification and Histone H3.1/H3.2. (2015)
  • Author(s): Hayashi M, Maehara K, Harada A, Semba Y, Kudo K, Takahashi H, Oki S, Meno C, Ichiyanagi K, Akashi K, Ohkawa Y.
  • Journal Title: J Cell Biochem Volume: 117 Issue: 3 Pages: 780-792
  • DOI: 10.1002/jcb.25368
  • Peer Reviewed / Open Access
• [Journal Article] A New Screen for Tuberculosis Drug Candidates Utilizing a Luciferase-Expressing Recombinant Mycobacterium bovis Bacillus Calmette-Guéren. (2015)
  • Author(s): 2)Ozeki Y, Igarashi M, Doe M, Tamaru A, Kinoshita N, Ogura Y, Iwamoto T, Sawa R, Umekita M, Enany S, Nishiuchi Y, Osada-Oka M, Hayashi T, Niki M, Tateishi Y, Hatano M, Matsumoto S.
  • Journal Title: PLoS One Volume: 10 Pages: 214-221
  • DOI: 10.1016/j.jprot.2016.01.008
  • Peer Reviewed / Open Access
• [Journal Article] Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposon. (2015)
  • Author(s): Hatanaka Y, Inoue K, Oikawa M, Kamimura S, Ogonuki N, Kodam E, Ohkawa Y, Tsukada Y, Ogura A.
  • Journal Title: Proc Natl Acad Sci USA Volume: 112 Issue: 47 Pages: 14641-14646
  • DOI: 10.1073/pnas.1512775112
  • Peer Reviewed / Open Access
• [Journal Article] Influence of DNA methylation on positioning and DNA flexibility of nucleosomes with pericentric satellite DNA. (2015)
  • Author(s): Osakabe A, Adachi F, Arimura Y, Maehara K, Ohkawa Y, Kurumizaka H.
  • Journal Title: Open Biol. Volume: 5 Issue: 10 Pages: 150128-150128
  • DOI: 10.1098/rsob.150128
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Tissue-specific expression of histone H3 variants diversified after species separation. (2015)
  • Author(s): Maehara K, Harada A, Sato Y, Matsumoto M, Nakayama KI, Kimura H, Ohkawa Y.
  • Journal Title: Epigenetics Chromatin Volume: 8 Issue: 1 Pages: 1-17
  • DOI: 10.1186/s13072-015-0027-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies. (2015)
  • Author(s): Hayashi-Takanaka Y., Maehara K., Harada A., Umehara T., Yokoyama S., Obuse C., Ohkawa Y., Nozaki N., Kimura H.
  • Journal Title: Chromosome Res. Volume: 23 Issue: 4 Pages: 753-766
  • DOI: 10.1007/s10577-015-9486-4
  • Peer Reviewed / Open Access
• [Journal Article] Genomewide identification of target genes of histone methyltransferase dG9a during Drosophila embryogenesis (2015)
  • Author(s): Shimaji K, Konishi T, Tanaka S, Yoshida H, Kato Y, Ohkawa Y, Sato T, Suyama M, Kimura H, Yamaguchi M.
  • Journal Title: Genes to Cells Volume: 20 Issue: 11 Pages: 902-914
  • DOI: 10.1111/gtc.12281
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Engrafted Neural Stem/Progenitor Cells Promote Functional Recovery through Synapse Reorganization with Spared Host Neurons after Spinal Cord Injury. (2015)
  • Author(s): Yokota K, Kobayakawa K, Kubota K, Miyawaki A, Okano H, Ohkawa Y, Iwamoto Y, Okada S.
  • Journal Title: Stem Cell Reports. Volume: 5 Issue: 2 Pages: 264-277
  • DOI: 10.1016/j.stemcr.2015.06.004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] foxl3 is a germ cell-intrinsic factor involved in sperm-egg fate decision in medaka. (2015)
  • Author(s): Nishimura T, Sato T, Yamamoto Y, Watakabe I, Ohkawa Y, Suyama M, Kobayashi S, Tanaka M.
  • Journal Title: Science Volume: 349 Issue: 6245 Pages: 328-331
  • DOI: 10.1126/science.aaa2657
  • Peer Reviewed / Open Access
• [Journal Article] Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme. (2015)
  • Author(s): Nasipakb B, Padilla-Benavides T, Green K, Leszyk J, Mao W, Konda S, Sif S, Shaffer S, Ohkawa Y, Imbalzano AN.
  • Journal Title: Nat Commun. Volume: 6 Issue: 1 Pages: 7441-7441
  • DOI: 10.1038/ncomms8441
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] agplus: a rapid and flexible tool for aggregation plots. (2015)
  • Author(s): Maehara K, Ohkawa Y.
  • Journal Title: Bioinformatics. Volume: 18 Issue: 18 Pages: 3046-3047
  • DOI: 10.1093/bioinformatics/btv322
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture. (2015)
  • Author(s): Sugimoto N, Maehara K, Yoshida K, Yasukouchi S, Osano S, Watanabe S, Aizawa M, Yugawa T, et al.
  • Journal Title: Nucleic Acids Res. Volume: 43 Issue: 12 Pages: 5898-5911
  • DOI: 10.1093/nar/gkv509
  • Peer Reviewed / Open Access
• [Journal Article] PSMC5, a 19S Proteasomal ATPase, Regulates Cocaine Action in the Nucleus Accumbens. (2015)
  • Author(s): Ohnishi YH, Ohnishi YN, Nakamura T, Ohno M, Kennedy PJ, Yasuyuki O, Nishi A, Neve R, Tsuzuki T, Nestler EJ.
  • Journal Title: PLoS One Volume: 10(5) Issue: 5 Pages: e0126710-e0126710
  • DOI: 10.1371/journal.pone.0126710
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A cluster of non-coding RNAs activates the ESR1 locus during breast cancer adaptation to hormone deprivation (2015)
  • Author(s): S. Tomita, M.O. Abdalla, S. Fujiwara, H. Matsumori, K. Maehara, Y. Ohkawa, H. Iwase, N. Saitoh, and M. Nakao.
  • Journal Title: Nat. Commun. Volume: 6 Issue: 1 Pages: 6966-6966
  • DOI: 10.1038/ncomms7966
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies. (2015)
  • Author(s): Kawaguchi T, Tanigawa A, Naganuma T, Ohkawa Y, Souquere S, Pierron G, Hirose T.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 112 Issue: 14 Pages: 4304-4309
  • DOI: 10.1073/pnas.1423819112
  • NAID: 120005661435
  • Peer Reviewed / Open Access
• [Journal Article] Spatial re-organization of myogenic regulatory sequences temporally controls gene expression (2015)
  • Author(s): Harada A, Mallappa C, Okada S, Butler JT, Baker SP, Lawrence JB, Ohkawa Y, Imbalzano AN.
  • Journal Title: Nucleic Acids Research Volume: 43 Issue: 4 Pages: 2008-2021
  • DOI: 10.1093/nar/gkv046
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex (2015)
  • Author(s): Takahashi, H., Takigawa, I., Watanabe, M., Anwar, D., Shibata, M., Tomomori-Sato, C., Sato, S., Ranjan, A., Seidel, C.W., Tsukiyama, T., Mizushima, W., Hayashi, M., Ohkawa, Y., Conaway, J.W., Conaway, R.C. and Hatakeyama, S
  • Journal Title: Nature Commun. Volume: 5 Issue: 1 Pages: 5941-5941
  • DOI: 10.1038/ncomms6941
  • NAID: 120005621881
  • Peer Reviewed / Open Access
• [Journal Article] Incorporation of histone H3.1 suppresses the lineage potential of skeletal muscle (2015)
  • Author(s): Harada A, Maehara K, Sato Y, Konno D, Tachibana T, Kimura H, Ohkawa Y.
  • Journal Title: Nucleic Acids Research Volume: 43 Issue: 2 Pages: 775-786
  • DOI: 10.1093/nar/gku1346
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A Genome-Wide Analysis Identifies a Notch-RBP-Jκ-IL-7Rα Axis That Controls IL-17-Producing γδ T Cell Homeostasis in Mice. (2015)
  • Author(s): Nakamura M, Shibata K, Hatano S, Sato T, Ohkawa Y, Yamada H, Ikuta K, Yoshikai Y.
  • Journal Title: J Immunol. Volume: 194 Pages: 243-251
  • Peer Reviewed / Open Access
• [Journal Article] Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation. (2014)
  • Author(s): Matsumoto M, Baba A, Yokota T, Nishikawa H, Ohkawa Y, Kayama H, Kallies A, Nutt SL, Sakaguchi S, Takeda K, Kurosaki T, Baba Y.
  • Journal Title: Immunity. Volume: 41 Pages: 1040-1051
  • Peer Reviewed / Open Access
• [Journal Article] SraTailor: graphical user interface software for processing and visualizing ChIP-seq data. (2014)
  • Author(s): Oki S, Maehara K, Ohkawa Y, Meno C
  • Journal Title: Genes to Cells Volume: 19 Issue: 12 Pages: 919-926
  • DOI: 10.1111/gtc.12190
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans (2014)
  • Author(s): Kobayakawa K, Kumamaru H, Saiwai H, Kubota K, Ohkawa Y, Kishimoto J, Yokota K, Ideta R, Shiba K, Tozaki-Saitoh H, Inoue K, Iwamoto Y, Okada S
  • Journal Title: Science Translational Medicine Volume: 6 Issue: 256 Pages: 256-256
  • DOI: 10.1126/scitranslmed.3009430
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Regulation of RNA polymerase II activation by histone acetylation in single living cells (2014)
  • Author(s): Stasevich TJ, Hayashi-Takanaka Y, Sato Y, Maehara K, Ohkawa Y, Sakata-Sogawa K, Tokunaga M, Nagase T, Nozaki N, McNally JG, Kimura H
  • Journal Title: Nature Volume: 516 Issue: 7530 Pages: 272-275
  • DOI: 10.1038/nature13714
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Establishment of neutralizing rat monoclonal antibodies for fibroblast growth factor-2. (2014)
  • Author(s): Tanaka M, Yamaguchi M, Shiota M, Kawamoto Y, Takahashi K, Inagaki A, Osada-Oka M, Harada A, Wanibuchi H, Izumi Y, Miura K, Iwao H, Ohkawa Y.
  • Journal Title: Monoclon Antib Immunodiagn Immunother. Volume: 33 Pages: 261-269
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide analysis of histone modifications in human endometrial stromal cells (2014)
  • Author(s): Tamura I, Ohkawa Y, Sato T, Suyama M, Jozaki K, Okada M, Lee L, Maekawa R, Asada H, Sato S, Yamagata Y, Tamura H, Sugino N
  • Journal Title: Mol. Endocrinol. Volume: 28 Issue: 10 Pages: 1656-1669
  • DOI: 10.1210/me.2014-1117
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification of Myelin Transcription Factor 1 (MyT1) as a Subunit of the Neural Cell Type-specific Lysine-specific Demethylase 1 (LSD1) Complex. (2014)
  • Author(s): Yokoyama A, Igarashi K, Sato T, Takagi K, Otsuka I M, Shishido Y, Baba T, Ito R, Kanno J, Ohkawa Y, Morohashi KI, Sugawara A.
  • Journal Title: J Biol Chem. Volume: 289 Pages: 18152-18162
  • Peer Reviewed / Open Access
• [Journal Article] Heterochromatin dynamics during differentiation process revealed by the DNA methylation reporter mouse, MethylRO. (2014)
  • Author(s): Ueda J, Maehara K, Mashiko D, Ichinose T, Yao T, Hori M, Sato Y, Kimura K, Ohkawa Y, Yamagata K.
  • Journal Title: Stem Cell Reports. Volume: 2 Pages: 910-924
  • Peer Reviewed / Open Access
• [Journal Article] Glycolytic gene as the targets of nuclear receptor Ad4BP/SF-1 (2014)
  • Author(s): Takashi Baba, Hiroyuki Otake, Tetsuya Sato, Kanako Miyabayashi, Yurina Shishido, Chia-Yih Wang, Yuichi Shima, Hiroshi Kimura, Mikako Yagi, Yasuhiro Ishihara, Shinjiro Hino, Hidesato Ogawa, Mitsuyoshi Nakao, Takeshi Yamazaki, Dongchon, Kang, Yasuyuki Ohkawa, Mikita Suyama, Bon-Chu Chung, Ken-ichirou Morohashi
  • Journal Title: Nature Commun Volume: 5 Issue: 1 Pages: 3634-3634
  • DOI: 10.1038/ncomms4634
  • Peer Reviewed / Open Access
• [Presentation] ヒストンH3バリアントの選択による転写基底レベル調節機構 (2017)
  • Author(s): 大川恭行
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2017-11-30
• [Presentation] 骨格筋分化のエピゲノム制御を捉える (2017)
  • Author(s): 大川恭行
  • Organizer: 第5回骨格筋生物学研究会
  • Place of Presentation: 東京大学駒場キャンパス
  • Year and Date: 2017-03-03
• [Presentation] The baselines of transcription levels are determined by selective incorporation of histone H3 variants (2017)
  • Author(s): 大川恭行
  • Organizer: Transcriptional and Epigenetic Control in Stem Cells (J1)
  • Place of Presentation: Resort at Squaw Creek, Olympic Valley, California, USA
  • Year and Date: 2017-01-08
  • Int'l Joint Research
• [Presentation] Histone variants and cell differentiation (2016)
  • Author(s): 大川恭行
  • Organizer: Colorado Chromatin Meeting 2016
  • Place of Presentation: Colorado, USA.
  • Year and Date: 2016-08-08
  • Int'l Joint Research
• [Presentation] トランスクリプトミクスで解析する骨格筋形成 (2016)
  • Author(s): 大川恭行
  • Organizer: 第2回日本筋学会学術集会
  • Place of Presentation: 国立研究開発法人国立精神・神経医療研究センター
  • Year and Date: 2016-08-05
• [Presentation] N6-methyladenosine is required for the processing of MyoD pre-mRNA for maintaining skeletal muscle differentiation potential. (2016)
  • Author(s): 大川恭行
  • Organizer: Keystone Symposia
  • Place of Presentation: Whistler Conference Centre
  • Year and Date: 2016-03-20
  • Int'l Joint Research
• [Presentation] 次世代スパースタープログラムの4年間 (2016)
  • Author(s): 大川恭行
  • Organizer: 新学術領域「動的クロマチン構造と機能」の若手の会シンポジウム
  • Place of Presentation: 早稲田大学 西早稲田キャンパス
  • Invited
• [Presentation] トランスクリプトミクスで解析する骨格筋形成 (2016)
  • Author(s): 大川恭行
  • Organizer: 第4回若手による骨格筋細胞研究会
  • Place of Presentation: ウィンクあいち
• [Presentation] トランスオミクス研究の新展開―全ての遺伝子をみるー (2016)
  • Author(s): 大川恭行
  • Organizer: 藤田保健衛生大学 医学会
  • Place of Presentation: 藤田学園フジタホール
  • Invited
• [Presentation] 遺伝子のすがたを全部見る (2016)
  • Author(s): 大川恭行
  • Organizer: 新学術領域クロマチン動構造主催の一般公開シンポジウム
  • Place of Presentation: 早稲田大学 国際会議場 井深大記念ホール
  • Invited
• [Presentation] Cell fate decision on chromatin by MyoD (2015)
  • Author(s): 大川 恭行
  • Organizer: BMB2010(第38回日本分子生物学会年会・第88回日本生化学会大会合同大会）
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2015-12-02
• [Presentation] The Diversity of Mouse Histone H3 Variants (2015)
  • Author(s): 大川 恭行
  • Organizer: International Symposium on Chromatin Structure,
  • Place of Presentation: Awaji Yumebutai International Conference Center
  • Year and Date: 2015-08-23
  • Int'l Joint Research
• [Presentation] 筋分化および形成破綻におけるエピゲノム制御 (2015)
  • Author(s): 大川 恭行
  • Organizer: 第1回日本筋学会学術集会
  • Place of Presentation: 国立精神・神経医療研究センター 研修棟ユニバーサルホール
  • Year and Date: 2015-08-08
  • Invited
• [Presentation] クロマチンコード解読への挑戦 -NGS解析の展開- (2015)
  • Author(s): 大川 恭行
  • Organizer: 第33回内分泌代謝学サマーセミナー
  • Place of Presentation: 柳川藩主立花邸 御花
  • Year and Date: 2015-07-10
  • Invited
• [Presentation] クロマチン構造にプログラムされた骨格筋分化能~エピゲノム解析で解読するヒストンバーコード~ (2015)
  • Author(s): 大川 恭行
  • Organizer: 千葉大学医学研究院開催セミナー
  • Place of Presentation: 千葉大学 医学部
  • Year and Date: 2015-04-15
  • Invited
• [Presentation] The diversity of mouse histone H3 variants. (2015)
  • Author(s): Yasuyuki Ohkawa
  • Organizer: Epigenomics (Z2)
  • Place of Presentation: Keystone ResortUSA
  • Year and Date: 2015-03-29 – 2015-04-03
• [Presentation] Incorporation of Histone H3 Variants Dictates the Lineage Potential of Skeletal Muscle. (2015)
  • Author(s): Yasuyuki Ohkawa
  • Organizer: Transcriptional and Epigenetic Influences on Stem Cell States (C9)
  • Place of Presentation: Sheraton Steamboat Resort USA
  • Year and Date: 2015-03-23 – 2015-03-28
• [Presentation] ヒストンバリアントが制御する骨格筋分化能 (2015)
  • Author(s): 大川 恭行
  • Organizer: クロマチン・デコーディング研究会
  • Place of Presentation: 国際高等研究所
  • Year and Date: 2015-03-20
  • Invited
• [Presentation] ヒストンH3バリアントの多様性 (2015)
  • Author(s): 大川 恭行
  • Organizer: ヒストンバリアント研究会
  • Place of Presentation: 東京工業大学 すずかけ台キャンパス
  • Year and Date: 2015-02-28
• [Presentation] High order chromatin remodeling in skeletal muscle differentiation (2015)
  • Author(s): 大川 恭行
  • Organizer: エピジェネティクス全体会議
  • Place of Presentation: 理化学研究所 多細胞システム形成研究センター
  • Year and Date: 2015-02-14
  • Invited
• [Presentation] 次世代シークエンサーによるエピゲノム解析 ～大規模情報処理パイプラインへの取り組み～ (2015)
  • Author(s): 大川 恭行
  • Organizer: 京都大学学術情報メディアセンターセミナー
  • Place of Presentation: 京都大学学術情報メディアセンター 南館 201マルチメディア講義室
  • Year and Date: 2015-01-26
  • Invited
• [Presentation] 骨格筋分化における空間クロマチン制御へのアプローチ (2015)
  • Author(s): 大川 恭行
  • Organizer: 定量生物学の会
  • Place of Presentation: 九州大学 筑紫キャンパス
  • Year and Date: 2015-01-11 – 2015-01-12
• [Presentation] ヒストンH3バリアントの多様性 (2014)
  • Author(s): 大川恭行
  • Organizer: 第37回日本分子生物学年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-11-26
• [Presentation] クロマチン構造制御による骨格筋分化運命機構の解明 (2014)
  • Author(s): 大川恭行
  • Organizer: 骨格筋研究会
  • Place of Presentation: コープイン京都
  • Year and Date: 2014-11-05
• [Presentation] 骨格筋分化におけるヒストンバリアントによるエピゲノム制御 (2014)
  • Author(s): 大川恭行
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2014-10-16
• [Presentation] ヒストンバリアントによる遺伝子選択 ～ヒストンバーコード解析の新たな展開～ (2014)
  • Author(s): 大川恭行
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-25
  • Invited
• [Presentation] ヒストンバリアントが制御する骨格筋分化能～ヒストンバーコード説の新たな展開～ (2014)
  • Author(s): 大川恭行
  • Organizer: 招聘セミナー講演
  • Place of Presentation: 基礎生物学研究所
  • Year and Date: 2014-09-11
  • Invited
• [Presentation] Incorporation of Histone H3 Variants Dictates the Lineage Potential of Skeletal Muscle. (2014)
  • Author(s): Akihito Harada, Kazumitsu Maehara, Yuko Sato, Hiroshi Kimura and Yasuyuki Ohkawa
  • Organizer: FASEB;Science Research Conferences
  • Place of Presentation: The Steamboat Grand Resort USA
  • Year and Date: 2014-07-20 – 2014-07-25
• [Presentation] Diversity of histone H3 variants on mouse genome (2014)
  • Author(s): Yasuyuki Ohkawa
  • Organizer: ENBO Workshop Histone varisnts
  • Place of Presentation: IGBMC in Strasbourg
  • Year and Date: 2014-06-02 – 2014-06-04
• [Book] Surgery Frontier (2015)
  • Author(s): 大川 恭行
  • Total Pages: 3
  • Publisher: ㈱メディカルレビュー社
• [Book] 実験医学 (2015)
  • Author(s): 上田潤，前原一満，大川恭行，山縣一夫
  • Total Pages: 9
  • Publisher: 羊土社
• [Book] 実験医学 (2015)
  • Author(s): 上田 潤，前原一満，大川恭行，山縣一夫
  • Publisher: 羊土社
• [Book] 実験医学 (2014)
  • Author(s): 大川恭行、原田哲仁
  • Publisher: 羊土社
• [Patent(Industrial Property Rights)] DNA結合タンパク質の結合領域の近傍に所望のDNA断片を挿入する方法 (2016)
  • Inventor(s): 大川恭行,,原田哲仁,胡桃坂仁志,木村宏,半田哲也,他2名
  • Industrial Property Rights Holder: 国立大学法人九州大学,国立大学法人東京工業大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-08-30