| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
|
|---|
| Outline of Final Research Achievements |
About one third of proteins function as protein complexes. Imbalances in the stoichiometry of subunits constituting protein complexes sometimes cause harmful effects on cellular functions. In this study, using budding yeast, we revealed a mechanism to avoid stoichiometry imbalances in protein complexes. We identified several proteins whose expressions were not increased as expected when their gene copy numbers were artificially increased. The buffering of protein expression was performed through active degradation of excess proteins by the ubiquitin-proteasome system.
|
