Mitochondrial dynamics in mammals and its molecular mechanism
| Project/Area Number |
26291032
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Kyushu University |
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Principal Investigator |
Koshiba Takumi 九州大学, 理学(系)研究科(研究院), 准教授 (70403970)
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| Co-Investigator(Kenkyū-buntansha) |
渡邊 利雄 奈良女子大学, 自然科学系, 教授 (60201208)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | ミトコンドリア / 分子機構 / 抗ウイルス自然免疫 / 形態調節 / 酵素機能 / 細胞内シグナル伝達 / ダイナミクス |
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| Outline of Final Research Achievements |
Mitochondria are dynamic organelles that undergo cycles of homotypic fusion and fission events, which are believed to play an important role in biologic process. Although the importance of mitochondrial dynamics is well documented, the molecular mechanism remain unclear.
Our aims of the project is to elucidate their knowledges of mitochondrial dynamics, and try to understand the mechanism at molecular level. In this project, (1) we generated mice deficient in molecules involved in mitochondrial dynamics, and also (2) we investigated relationship between mitochondrial dynamics and antiviral innate immunity in vitro.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity2014
Author(s)
Yoshizumi, T., Ichinohe, T., Sasaki, O., Otera, H., Kawabata, S., Mihara, K., and #Koshiba, T.
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Journal Title
Nature Communications
Volume: 5
Issue: 1
Pages: 4713-4713
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Loss of Miro1-directed retrograde mitochondrial movement results in a novel murine model for neuron disease2014
Author(s)
Nguyen, T.T., Oh, S.S., Weaver, D., Lewandowska, A., Maxfield, D., Schuler, M.H., Smith, N.K., Macfarlane, J., Saunders, G., Palmer, C.A., Debattisti, V., Koshiba, T., Pulst, S., Feldman, E.L., Hajnóczky, G., and Shaw, J.M.
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 111
Issue: 35
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] The N-terminal Arg residue is essential for autocatalytic activation of a lipopolysaccharide-responsive protease zymogen2014
Author(s)
Kobayashi, Y., Shiga, T., Shibata, T., Sako, M., Maenaka, K., Koshiba, T., Mizumura, H., Oda, T., and Kawabata, S.
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Journal Title
Journal of Biological Chemistry
Volume: 289
Issue: 37
Pages: 25987-25995
DOI
Related Report
Peer Reviewed
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