| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
|
|---|
| Outline of Final Research Achievements |
A detailed functional analysis of fmi mutant in the pupal stages revealed that the Fmi promotes the extension of filopodia and that Gogo has a function to antagonize that effect. This supressive function of Gogo helps the R8 axons to maintain their distance and prevent them from bundling. In the later half of the pupal stage, when Gogo expression become down regulated, filopodia extension promoted by Fmi takes place. These data suggest that Gogo function to suppress the filopodia extension contributes to shape the axonal array with a constant distance among axons at the surface of the target ganglion.
|
