| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
Previous population genomics studies have revealed that Asian-specific strong positive selections occurred on nonsynonymous variants in ABCC11 and EDAR, which are involved in the functions of sweat glands. In this study, we aimed to clarify the associations of these variants with the individual variation in skin functions and skin microbiome. As a result, we observed that both of the Asian-type variants are associated with a decreased amount of porphyrin on facial surface, which is mainly produced by Propionibacterium acnes. Moreover, an interaction between the effects of the two variants suggests that these variants co-evolved in Asia. Further functional studies and population genetics studies will be needed to elucidate the epistasis between the variants of ABCC11 and EDAR.
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