Specificity of cold adaptation in human thermogenesis and multiple organs coordination

• Project/Area Number: 26291099
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Applied anthropology
• Research Institution: Hokkaido University (2016-2017); Chiba Institute of Technology (2014-2015)
• Principal Investigator: WAKABAYASHI HITOSHI 北海道大学, 工学研究院, 准教授 (50452793)
• Co-Investigator(Kenkyū-buntansha): 金田 晃一 千葉工業大学, 先進工学部, 准教授 (10534589) ; 引原 有輝 千葉工業大学, 創造工学部, 准教授 (10455420) ; 栃原 裕 九州大学, 芸術工学研究院, 名誉教授 (50095907)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2014: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
• Keywords: 寒冷適応 / 褐色脂肪細胞 / 骨格筋 / 寒冷誘発性代謝 / 皮膚血流 / 褐色脂肪組織 / 組織連関 / 褐色脂肪 / 全身的協関 / 代謝 / 骨格筋代謝

Outline of Final Research Achievements

This study investigated specificity of adaptation in human thermoregulatory response after repetitions of cold exposure which initiated different thermoregulatory response. Repeated local cooling of forearm muscle increased oxidative muscle metabolism during hand grip exercise. We investigated the relationship between thermoregulatory response in cold climate chamber and brown adipose tissue activity assessed using FDG-PET/CT. Additionally, we investigated the adaptation in the thermoregulatory response after repeated cold exposure which induced only non-shivering thermogenesis.

Research Products

• [Journal Article] Effect of repeated forearm muscle cooling on the adaptation of skeletal muscle metabolism in humans (2017)
  • Author(s): Hitoshi Wakabayashi, Takayuki Nishimura, Titis Wijayanto, Shigeki Watanuki, Yutaka Tochihara
  • Journal Title: International Journal of Biometeorology Volume: 61 Issue: 7 Pages: 1261-1267
  • DOI: 10.1007/s00484-016-1303-z
  • NAID: 120006484238
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Exercise performance in acute and chronic cold exposure (2015)
  • Author(s): Wakabayashi H, Oksa J, Tipton MJ
  • Journal Title: The Journal of Physical Fitness and Sports Medicine Volume: 4 Issue: 2 Pages: 177-185
  • DOI: 10.7600/jpfsm.4.177
  • NAID: 130005073623
  • ISSN: 2186-8123, 2186-8131
• [Presentation] 軽度寒冷環境における各臓器の代謝応答 (2018)
  • Author(s): 松本健太郎，小堀祐資，若林斉，亀谷俊満，斉藤昌之．
  • Organizer: 空気調和・衛生工学会北海道支部第52回学術講演会
• [Presentation] Multiple organs coordination for cold induced thermogenesis in Japanese males. (2017)
  • Author(s): Wakabayashi H, Matsumoto K, Kobori Y, Saito M, Matsushita M, Kameya T.
  • Organizer: The 17th International Conference on Environmental Ergonomics
  • Int'l Joint Research / Invited
• [Presentation] 繰り返し軽度寒冷曝露が寒冷誘発性代謝の代謝成分に及ぼす影響 (2017)
  • Author(s): 小堀祐資，松本健太郎，若林斉，斉藤昌之．
  • Organizer: 日本生理人類学会第76回大会
• [Presentation] 骨格筋における寒冷誘発性代謝の新しい評価方法の検討 (2017)
  • Author(s): 小堀祐資，若林斉
  • Organizer: 第51回空気調和・衛生工学会北海道支部学術講演会
  • Place of Presentation: 北海道大学フロンティア応用科学研究棟（札幌市）
• [Presentation] Physical performance in cold environment and adaptation after repeated cold exposure (2015)
  • Author(s): Wakabayashi H
  • Organizer: The 12th International Congress of Physiological Anthropology
  • Place of Presentation: 東京ベイ幕張ホール（千葉県千葉市）
  • Year and Date: 2015-10-27
  • Int'l Joint Research
• [Presentation] ヒト骨格筋代謝機能に見られる寒冷適応 (2015)
  • Author(s): 若林斉
  • Organizer: 日本生理人類学会第72回大会
  • Place of Presentation: 北海道大学医学部学友会館「フラテ」（北海道札幌市）
  • Year and Date: 2015-05-30
  • Invited
• [Presentation] Adaptation in human skeletal muscle metabolism after repeated intense local tissue cooling (2015)
  • Author(s): Wakabayashi H
  • Organizer: International Symposium on Human Adaptation to Environment and Whole-body Coordination
  • Place of Presentation: 神戸大学（兵庫県神戸市）
  • Year and Date: 2015-03-14 – 2015-03-16