Immunomodulation by foods based on elucidation of novel interactions of intestinal immune cells
Project/Area Number |
26292065
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Food science
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Research Institution | The University of Tokyo |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
高橋 宜聖 国立感染症研究所, 免疫部, 室長 (60311403)
細野 朗 日本大学, 生物資源科学部, 教授 (70328706)
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Research Collaborator |
ADACHI Haruyo 東京大学, 農学生命科学研究科, 特任助教 (20595962)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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Keywords | 食品 / 食品機能 / 食品免疫 / 腸管免疫 / 制御性T細胞 / 樹状細胞 / 乳酸菌 / 濾胞性T細胞 / 濾胞性ヘルパーT細胞 |
Outline of Final Research Achievements |
The purpose of this study was to elucidate novel interactions of intestinal immune cells to develop immunomodulating functional foods. We firstly examined the dendritic cell subset of mouse mesenteric lymph node with high regulatory T cell inducing function. Then, we examined the gene expression profiles of two regulatory T cell populations induced in oral tolerance by DNA microarray. Furthermore, the mechanism of induction of T follicular helper cells by lactic acid bacteria for food was examined in an in vitro culture with dendritic cells, T cells and B cells. Finally the responses of innate lymphoid cells of gut-associated lymphoid to intestinal bacteria were examined.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Critical role of intestinal interleukin-4 modulating regulatory T Cells for desensitization, tolerance, and inflammation of food allergy.2017
Author(s)
Nakajima-Adachi, H., Shibahara, K., Fujimura, Y., Takeyama, J., Hiraide, E., Kikuchi, A., Murakami, H., Hosono, A., Nochi, T., Wakatsuki, Y., Shimojo, N., Kaminogawa, S., Sato, R., Kiyono, H. and Hachimura, S.
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Journal Title
PLoS One
Volume: 12
Issue: 2
Pages: e0172795-e0172795
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Post-transcriptional regulation of Toll-interacting protein in the intestinal epithelium2016
Author(s)
Y. Sugi, K. Takahashi, K. Kurihara, K. Nakata, H. Narabayashi, Y. Hamamoto, M. Suzuki, M. Tsuda, S. Hanazawa, A. Hosono, S. Kaminogawa
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Journal Title
PLoS ONE
Volume: 11
Issue: 10
Pages: e0164858-e0164858
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Epitope Mapping of the Hemagglutinin Molecule of A/(H1N1)pdm09 Virus by Using Monoclonal Antibody Escape Mutants2014
Author(s)
Yoko Matsuzaki, Kanetsu Sugawara., Mina Nakauchi, Yoshimasa Takahashi, Taishi Onodera, Yasuko Tsunetsugu-Yokota, Takayuki Matsumura, Manabu Ato, Kazuo Kobayashi, Yoshitaka Shimotai, Katsumi Mizuta, Seiji Hongo, Masato Tashiro, Eri Nobusawa
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Journal Title
J. Virol.
Volume: 88
Issue: 21
Pages: 12364-12373
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 加齢性炎症と食品による抑制2015
Author(s)
八村敏志、宮川拓也、片倉喜範、田之倉優
Organizer
日本食品免疫学会2015年度大会
Place of Presentation
東京大学(東京)
Year and Date
2015-10-15
Related Report
Invited
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