Development of novel pi-electron deficient nitrogen-containing heterocycles for dehydrocondensations
| Project/Area Number |
26293003
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山田 耕平 金沢大学, 薬学系, 助教 (40583232)
北村 正典 金沢大学, 薬学系, 准教授 (80453835)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Keywords | 脱水縮合剤 / トリアジン / 電子欠乏性含窒素芳香環 / アルキル化剤 / アミド / 脱水縮合 / エステル / 含窒素複素環 / 含窒素芳香環 |
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| Outline of Final Research Achievements |
We have developed novel dehydrocondensing reagents related to DMT-MM, which enables us to conduct reactions between carboxylic acids and amines in aqueous or alcoholic solvents to give amides. In this research project, we succeeded in synthesizing highly activated and/or functionalized dehydrocondensing reagents by the detailed study on the substituent effect and the skeletal transformation of pi-electron-deficient triazines. Moreover, based on the obtained results, novel alkylating reagents and methods for chemical transformation were also developed.
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Report
(4 results)
Research Products
(51 results)
