Research Project
Grant-in-Aid for Scientific Research (B)
TGF-β treatment to breast cancer cell lines induces epithelial-mesenchymal transition. We confirmed suppression of EZH2 expression by shRNA decreased modification levels of Histone H3K27me3. With this method, we analyzed the effect of suppression of H3K27me3 modification on transcript. Contrary to expectations, suppression of H3K27me3 did not cause a major effect.Next to breast cancer cell lines, we analyzed EZH2 deficient B lymphocytes. As we expected, modification of H3K27me3 in these downregulated and we obtained list of transcriptional activated genes. We also analyzed the modification level of H3K4me1 as a marker of enhancer activity. We identified the region where H3K4me1 increased after EZH2 deletion. However, we could not recognize which genes were regulated by corresponding enhancers.
All 2017 2016 2015 2014 Other
All Journal Article (29 results) (of which Int'l Joint Research: 4 results, Peer Reviewed: 29 results, Open Access: 22 results, Acknowledgement Compliant: 14 results) Presentation (14 results) (of which Invited: 1 results) Remarks (2 results)
Genes Cells
Volume: 印刷中 Issue: 4 Pages: 360-375
10.1111/gtc.12482
Cell Reports
Volume: 18 Issue: 10 Pages: 2401-2414
10.1016/j.celrep.2017.02.029
Nat Methods
Volume: 14 Issue: 3 Pages: 251-258
10.1038/nmeth.4116
J.Biol.Chem.
Volume: 印刷中 Issue: 19 Pages: 8019-8037
10.1074/jbc.m116.774547
Cancer Sci
Volume: 印刷中 Issue: 6 Pages: 1263-1270
10.1111/cas.13233
Nat. Immunol.
Volume: 18 Issue: 1 Pages: 64-73
10.1038/ni.3614
Sci Signal. doi: 10.1126/scisignal.aah4117.
Volume: 10 Issue: 460 Pages: 1-15
10.1126/scisignal.aah4117
Mol Cell Biol
Volume: 37 Issue: 4
10.1128/mcb.00439-16
Brain Dev.
Volume: 39 Issue: 4 Pages: 337-340
10.1016/j.braindev.2016.11.006
10.1128/mcb.00347-16
Cancer Sci.
Volume: 107 Issue: 12 Pages: 1776-1784
10.1111/cas.13097
Mol. Ecol.
Volume: 25 Issue: 18 Pages: 4450-4460
10.1111/mec.13782
Journal of Epidemiology
Volume: 26 Issue: 9 Pages: 493-511
10.2188/jea.JE20150268
130005409018
Cell Rep.
Volume: 16 Issue: 3 Pages: 696-706
10.1016/j.celrep.2016.06.034
J. Biochem.
Volume: 160 Pages: 333-344
40021050454
Genes Cells.
Volume: in press Issue: 6 Pages: 553-567
10.1111/gtc.12365
J Hum Genet.
Volume: advance online publication Issue: 6 Pages: 547-553
10.1038/jhg.2016.12
Nat Commun
Volume: 7 Issue: 1 Pages: 11624-11624
10.1038/ncomms11624
Hum Genet.
Volume: 134 Issue: 6 Pages: 649-658
10.1007/s00439-015-1553-6
Am J Med Genet A.
Volume: in press Issue: 4 Pages: 777-785
10.1002/ajmg.a.36987
Genes to cells
Volume: 7 Issue: 7 Pages: 543-562
10.1111/gtc.12250
Reprod.Biol.
Volume: 15 Issue: 3 Pages: 131-138
10.1016/j.repbio.2015.05.001
120005828503
Mol Immunol.
Volume: 68 Issue: 2 Pages: 223-33
10.1016/j.molimm.2015.08.012
Arterioscler Thromb Vasc Biol.
Volume: 35 Issue: 10 Pages: 2172-2184
10.1161/atvbaha.115.305872
Molecular and cellular biology
Volume: 20 Issue: 20 Pages: 3517-3527
10.1128/mcb.00343-15
Mol Cell
Volume: 57 Issue: 2 Pages: 247-260
10.1016/j.molcel.2014.12.002
Ann Hematol
Volume: 93 Issue: 9 Pages: 1515-1522
10.1007/s00277-014-2090-4
PLoS One
Volume: 9(6) Issue: 6 Pages: e98521-e98521
10.1371/journal.pone.0098521
Neuromuscul. Disord.
Volume: 24(12) Issue: 12 Pages: 1068-1072
10.1016/j.nmd.2014.07.008
http://www.devgen.med.tohoku.ac.jp/
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